{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:21:06Z","timestamp":1783066866489,"version":"3.54.6"},"reference-count":34,"publisher":"Galenos Yayinevi","issue":"4","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Phys Med Rehab"],"accepted":{"date-parts":[[2025,1,7]]},"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    This study aims to investigate mercaptoalbumin and non-mercaptoalbumin (HNA%) levels in the serum of patients with idiopathic carpal tunnel syndrome (CTS) and to explore the correlation between serum HNA% and symptom severity, functional status, electrophysiological findings (EPFs), median nerve cross-sectional area (MNCSA) measured by ultrasound, and vitamin D levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    Between April 2022 and November 2023, this prospective, case-controlled study included a total of 47 patients diagnosed with bilateral CTS (6 males, 41 females; mean age: 45.4\u00b19.0 years; range, 25 to 60 years) and 34 healthy controls (4 males, 30 females; mean age: 42.5\u00b110.8 years; range, 27 to 60 years) were included. Evaluation parameters included pain as measured by Visual Analog Scale (VAS), pinch grip strength (kg), Boston Carpal Tunnel Questionnaire (BCTQ), EPF, MNCSA by ultrasonography (mm\n                    <jats:sup>2<\/jats:sup>\n                    ), mercaptoalbumin and non-mercaptoalbumin ratio in serum (HNA%=HNA \/Total albumin \u00d7100) and 25(OH)D.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The MNCSA was significantly higher in patients with CTS than healthy controls (p&lt;0.001). The HNA% was significantly higher and 25(OH)D levels were significantly lower in patients with CTS than in healthy controls (p&lt;0.001 and p=0.003, respectively). The HNA% was positively correlated symptom severity score (SSS) and functional status score (FSS) (r=0.396, p=0.006; r=0.29, p=0.042, respectively), and negatively correlated with 25(OH)D (r=\u20130.320, p=0.028). There was no relationship between HNA% and EPF and MNCSA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion: Our study results suggest that HNA% may be a new biomarker of oxidative stress in CTS. There is a relationship between HNA% and symptom severity, functional status, and low vitamin D levels.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.5606\/tftrd.2025.15426","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:31:38Z","timestamp":1764689498000},"page":"480-488","source":"Crossref","is-referenced-by-count":1,"title":["Relationships between serum mercaptoalbumin\/non-mercaptoalbumin ratio, 25(OH)D level, symptom severity, functional status and median nerve cross-sectional area in carpal tunnel syndrome"],"prefix":"10.4274","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-0133","authenticated-orcid":false,"given":"\u0130lknur","family":"Aykurt Karl\u0131bel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-0372","authenticated-orcid":false,"given":"Yasemin","family":"\u00dcst\u00fcnda\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-0525","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Ye\u015fil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-1751","authenticated-orcid":false,"given":"Elif","family":"Yalcin Arikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-226X","authenticated-orcid":false,"given":"Hande","family":"\u00d6zgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Padua L, Coraci D, Erra C, Pazzaglia C, Paolasso I, Loreti C, et al. 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