{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:21:27Z","timestamp":1783066887858,"version":"3.54.6"},"reference-count":35,"publisher":"Galenos Yayinevi","issue":"4","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Phys Med Rehab"],"accepted":{"date-parts":[[2025,3,22]]},"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    This study aims to evaluate the effects of vitamin D supplementation at different doses and dose intervals on upper extremity muscle strength, muscle thickness, and functional independence of patients with paraplegic spinal cord injury (SCI).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    This prospective controlled clinical trial included 64 paraplegic patients (45 males, 19 females; mean age: 39.7\u00b111.5 years; range, 18 to 64 years) with serum 25-hydroxyvitamin D (25[OH]D) levels &lt;20 ng\/mL between June 2020 and June 2021. Participants were divided into three groups: control (n=20), daily supplementation with 6000 IU cholecalciferol (n=23), and weekly supplementation with 50,000 IU cholecalciferol (n=21) for eight weeks. Hand grip strength was assessed with a dynamometer, muscle thickness was measured using ultrasonography, and functional independence was evaluated with the Spinal Cord Independence Measure III.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Serum 25(OH)D levels significantly increased in both supplementation groups compared to baseline (p=0.001). Nondominant hand grip strength significantly improved in both groups (daily, p=0.025; weekly, p=0.038). Muscle thickness of the biceps brachii significantly increased in the daily group (p&lt;0.05), while triceps brachii thickness significantly improved in both groups (p&lt;0.001). Spinal Cord Independence Measure III scores, encompassing self-care, respiratory-sphincter control, and mobility, showed significant improvements in the supplementation groups (p&lt;0.05), but no changes were observed in the control group. No significant differences were found between daily and weekly supplementation regimens.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Vitamin D supplementation, whether daily or weekly, improved muscle performance and functional independence in individuals with SCI. While these findings support the inclusion of vitamin D replacement in rehabilitation programs, larger and longerterm studies are needed to confirm the benefits.\n                  <\/jats:p>","DOI":"10.5606\/tftrd.2025.15668","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:31:38Z","timestamp":1764689498000},"page":"508-519","source":"Crossref","is-referenced-by-count":0,"title":["The effects of weekly or daily oral cholecalciferol use on muscle strength, muscle thickness, and functional independence in patients with spinal cord injury"],"prefix":"10.4274","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-3814","authenticated-orcid":false,"given":"Demet","family":"Ferahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-4428","authenticated-orcid":false,"given":"Kadriye","family":"\u00d6ne\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Lamarche J, Mailhot G. 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