{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:21:55Z","timestamp":1783066915417,"version":"3.54.6"},"reference-count":37,"publisher":"Galenos Yayinevi","issue":"4","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Phys Med Rehab"],"accepted":{"date-parts":[[2025,11,25]]},"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    This study aims to investigate the effects of swimming exercise on arthritis severity, radiological joint damage, and leptinrelated molecular changes in experimental rheumatoid arthritis (RA) in rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods:<\/jats:bold>\n                    A total of 30 male Wistar rats were randomly assigned to three groups (n=10 per group): Control, Arthritis, and Exercise + Arthritis. Experimental arthritis was induced by a single intradermal injection of Complete Freund\u2019s Adjuvant (CFA). The Exercise + Arthritis group underwent a six-week swimming protocol (1 h\/day, five days\/week), beginning two weeks before arthritis induction and continuing thereafter. Arthritis severity was assessed by visual scoring, radiological analysis, and histopathological evaluation. Plasma concentrations of leptin and matrix metalloproteinases (MMP-1, MMP-3, MMP-8, MMP-13) were measured using enzyme-linked immunosorbent assay (ELISA), and leptin receptor expression in paw tissues was analyzed immunohistochemically.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The Exercise + Arthritis group exhibited significantly lower visual arthritis scores (p=0.002), reduced ankle swelling (p&lt;0.001), and decreased cartilage and bone damage radiologically (p=0.045) compared to the Arthritis group. Histopathological evaluation revealed that swimming exercise markedly attenuated inflammatory cell infiltration, pannus formation, and bone resorption. Although plasma leptin and MMP levels did not differ between the groups (p&gt;0.05), leptin receptor expression, considered to be associated with joint damage, was found to be significantly lower in the Exercise + Arthritis group (p=0.009). Swimming exercise reduced arthritis severity and joint damage.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Moderate-intensity swimming exerts protective, anti-inflammatory effects in experimental RA by reducing inflammation and preserving joint structure in rats, possibly through modulating leptin receptor expression and inflammatory pathways. Although regular swimming may serve as a useful adjunct to slow disease progression and joint damage in RA in rats, the translational relevance of these results remains uncertain in humans.\n                  <\/jats:p>","DOI":"10.5606\/tftrd.2025.17494","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:31:38Z","timestamp":1764689498000},"page":"595-606","source":"Crossref","is-referenced-by-count":0,"title":["Protective effects of swimming exercise on experimental rheumatoid arthritis in rats through modulation of leptin receptor expression and inflammation"],"prefix":"10.4274","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3139-3540","authenticated-orcid":false,"given":"Tu\u011f\u00e7e","family":"Yava\u015f Duras\u0131ll\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-5383","authenticated-orcid":false,"given":"Co\u015fkun","family":"Zateri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-0294","authenticated-orcid":false,"given":"P\u0131nar","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-4226","authenticated-orcid":false,"given":"Dilek","family":"\u015eaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-1633","authenticated-orcid":false,"given":"Ufuk","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-6364","authenticated-orcid":false,"given":"Ozan","family":"Karata\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-0308","authenticated-orcid":false,"given":"Leman","family":"Sencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8796-6363","authenticated-orcid":false,"given":"Dilek","family":"\u00dclker \u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0510-9852","authenticated-orcid":false,"given":"Mustafa","family":"Edremitlio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Tanaka Y. A review of upadacitinib in rheumatoid arthritis. Mod Rheumatol 2020;30:779-87. doi: 10.1080\/14397595.2020.1782049.","DOI":"10.1080\/14397595.2020.1782049"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Lin YJ, Anzaghe M, Sch\u00fclke S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells 2020;9:880. doi: 10.3390\/cells9040880.","DOI":"10.3390\/cells9040880"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Morinobu A. JAK inhibitors for the treatment of rheumatoid arthritis. Immunol Med 2020;43:148-55. doi: 10.1080\/25785826.2020.1770948.","DOI":"10.1080\/25785826.2020.1770948"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Peres D, Sagawa Y Jr, Dugu\u00e9 B, Domenech SC, Tordi N, Prati C. The practice of physical activity and cryotherapy in rheumatoid arthritis: Systematic review. Eur J Phys Rehabil Med 2017;53:775-87. doi: 10.23736\/S1973- 9087.16.04534-2.","DOI":"10.23736\/S1973-9087.16.04534-2"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Pope JE. Management of fatigue in rheumatoid arthritis. RMD Open 2020;6:e001084. doi: 10.1136\/ rmdopen-2019-001084.","DOI":"10.1136\/rmdopen-2019-001084"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"van den Ende CH, Hazes JM, le Cessie S, Mulder WJ, Belfor DG, Breedveld FC, et al. Comparison of high and low intensity training in well controlled rheumatoid arthritis. Results of a randomised clinical trial. Ann Rheum Dis 1996;55:798-805. doi: 10.1136\/ard.55.11.798.","DOI":"10.1136\/ard.55.11.798"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"Navarro F, Bacurau AV, Almeida SS, Barros CC, Moraes MR, Pesquero JL, et al. Exercise prevents the effects of experimental arthritis on the metabolism and function of immune cells. Cell Biochem Funct 2010;28:266-73. doi: 10.1002\/cbf.1647.","DOI":"10.1002\/cbf.1647"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Alkatan M, Baker JR, Machin DR, Park W, Akkari AS, Pasha EP, et al. Improved function and reduced pain after swimming and cycling training in patients with osteoarthritis. J Rheumatol 2016;43:666-72. doi: 10.3899\/jrheum.151110.","DOI":"10.3899\/jrheum.151110"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Williamson E, McConkey C, Heine P, Dosanjh S, Williams M, Lamb SE. Hand exercises for patients with rheumatoid arthritis: An extended follow-up of the SARAH randomised controlled trial. BMJ Open 2017;7:e013121. doi: 10.1136\/ bmjopen-2016-013121.","DOI":"10.1136\/bmjopen-2016-013121"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Kelley GA, Kelley KS, Callahan LF. Community-deliverable exercise and anxiety in adults with arthritis and other rheumatic diseases: A systematic review with meta-analysis of randomised controlled trials. BMJ Open 2018;8:e019138. doi: 10.1136\/bmjopen-2017-019138.","DOI":"10.1136\/bmjopen-2017-019138"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Greysen HM, Hong OS, Katz P. The association between yoga use, physical function, and employment in adults with rheumatoid arthritis. Holist Nurs Pract 2019;33:71-9. doi: 10.1097\/HNP.0000000000000296.","DOI":"10.1097\/HNP.0000000000000296"},{"key":"ref-12","doi-asserted-by":"crossref","unstructured":"Becic T, Studenik C, Hoffmann G. Exercise increases adiponectin and reduces leptin levels in prediabetic and diabetic individuals: Systematic review and meta-analysis of randomized controlled trials. Med Sci (Basel) 2018;6:97. doi: 10.3390\/medsci6040097.","DOI":"10.3390\/medsci6040097"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Fedewa MV, Hathaway ED, Ward-Ritacco CL, Williams TD, Dobbs WC. The effect of chronic exercise training on leptin: A systematic review and meta-analysis of randomized controlled trials. Sports Med 2018;48:1437-50. doi: 10.1007\/s40279-018-0897-1.","DOI":"10.1007\/s40279-018-0897-1"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Sun L, Lv Y, Tian J, Yu T, Niu F, Zhang X, et al. Regular swimming exercise attenuated neuroma pain in rats: Involvement of leptin and adiponectin. J Pain 2019;20:1112- 24. doi: 10.1016\/j.jpain.2019.02.097.","DOI":"10.1016\/j.jpain.2019.02.097"},{"key":"ref-15","doi-asserted-by":"crossref","unstructured":"Yu N, Ruan Y, Gao X, Sun J. Systematic review and metaanalysis of randomized, controlled trials on the effect of exercise on serum leptin and adiponectin in overweight and obese individuals. Horm Metab Res 2017;49:164-73. doi: 10.1055\/s-0042-121605.","DOI":"10.1055\/s-0042-121605"},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Higa TS, Bergamo FC, Mazzucatto F, Fonseca-Alaniz MH, Evangelista FS. Physical training prevents body weight gain but does not modify adipose tissue gene expression. Braz J Med Biol Res 2012;45:988-94. doi: 10.1590\/s0100- 879x2012007500097.","DOI":"10.1590\/S0100-879X2012007500097"},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Uysal N, Agilkaya S, Sisman AR, Camsari UM, Gencoglu C, Dayi A, et al. Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats. J Chem Neuroanat 2017;81:27-33. doi: 10.1016\/j.jchemneu.2017.02.004.","DOI":"10.1016\/j.jchemneu.2017.02.004"},{"key":"ref-18","doi-asserted-by":"crossref","unstructured":"MacDonald IJ, Liu SC, Huang CC, Kuo SJ, Tsai CH, Tang CH. Associations between adipokines in arthritic disease and implications for obesity. Int J Mol Sci 2019;20:1505. doi: 10.3390\/ijms20061505.","DOI":"10.3390\/ijms20061505"},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Francisco V, Ruiz-Fern\u00e1ndez C, Pino J, Mera A, Gonz\u00e1lezGay MA, G\u00f3mez R, et al. Adipokines: Linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol 2019;165:196-206. doi: 10.1016\/j. bcp.2019.03.030.","DOI":"10.1016\/j.bcp.2019.03.030"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"Del Prete A, Salvi V, Sozzani S. Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm 2014;2014:425068. doi: 10.1155\/2014\/425068.","DOI":"10.1155\/2014\/425068"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Fujii Y, Inoue H, Arai Y, Shimomura S, Nakagawa S, Kishida T, et al. Treadmill running in established phase arthritis inhibits joint destruction in rat rheumatoid arthritis models. Int J Mol Sci 2019;20:5100. doi: 10.3390\/ ijms20205100.","DOI":"10.3390\/ijms20205100"},{"key":"ref-22","doi-asserted-by":"crossref","unstructured":"Shan S, Zhou Y, Yu J, Yang Q, Pan D, Wang Y, et al. Therapeutic treatment of a novel selective JAK3\/JAK1\/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis. Int Immunopharmacol 2019;77:105914. doi: 10.1016\/j.intimp.2019.105914.","DOI":"10.1016\/j.intimp.2019.105914"},{"key":"ref-23","doi-asserted-by":"crossref","unstructured":"Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: An update. Clin Endocrinol (Oxf) 2006;64:355-65. doi: 10.1111\/j.1365- 2265.2006.02474.x.","DOI":"10.1111\/j.1365-2265.2006.02474.x"},{"key":"ref-24","doi-asserted-by":"crossref","unstructured":"Volpon JB, Silva AV, Falcai MJ, Louzada MJ, Zamarioli A, Kotake BG, et al. 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Z Rheumatol 2013;72:375-82. doi: 10.1007\/ s00393-012-1083-8.","DOI":"10.1007\/s00393-012-1083-8"},{"key":"ref-27","doi-asserted-by":"crossref","unstructured":"Ackerman NR, Rooks WH 2nd, Shott L, Genant H, Maloney P, West E. Effects of naproxen on connective tissue changes in the adjuvant arthritic rat. Arthritis Rheum 1979;22:1365- 74. doi: 10.1002\/art.1780221208.","DOI":"10.1002\/art.1780221208"},{"key":"ref-28","doi-asserted-by":"crossref","unstructured":"Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, et al. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol 2009;183:5928-37. doi: 10.4049\/ jimmunol.0901826.","DOI":"10.4049\/jimmunol.0901826"},{"key":"ref-29","doi-asserted-by":"crossref","unstructured":"Scotece M, Mobasheri A. Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes. Life Sci 2015;140:75-8. doi: 10.1016\/j.lfs.2015.05.025.","DOI":"10.1016\/j.lfs.2015.05.025"},{"key":"ref-30","doi-asserted-by":"crossref","unstructured":"Dorneles GP, da Silva I, Boeira MC, Valentini D, Fonseca SG, Dal Lago P, et al. Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men. Scand J Med Sci Sports 2019;29:1755-65. doi: 10.1111\/sms.13506.","DOI":"10.1111\/sms.13506"},{"key":"ref-31","doi-asserted-by":"crossref","unstructured":"Fang J, Tang M. Exercise improves high fat diet-impaired vascular function. Biomed Rep 2017;7:337-42. doi: 10.3892\/ br.2017.972.","DOI":"10.3892\/br.2017.972"},{"key":"ref-32","doi-asserted-by":"crossref","unstructured":"Siqueira US, Orsini Valente LG, de Mello MT, Szejnfeld VL, Pinheiro MM. Effectiveness of aquatic exercises in women with rheumatoid arthritis: A randomized, controlled, 16-week intervention-The HydRA Trial. Am J Phys Med Rehabil 2017;96:167-75. doi: 10.1097\/ PHM.0000000000000564.","DOI":"10.1097\/PHM.0000000000000564"},{"key":"ref-33","doi-asserted-by":"crossref","unstructured":"Ghiasi R, Ghadiri Soufi F, Mohaddes G, Alihemmati A, Somi MH, Ebrahimi H, et al. Influance of regular swimming on serum levels of CRP, IL-6, TNF-\u03b1 in highfat diet-induced type 2 diabetic rats. Gen Physiol Biophys 2016;35:469-76. doi: 10.4149\/gpb_2016007.","DOI":"10.4149\/gpb_2016007"},{"key":"ref-34","doi-asserted-by":"crossref","unstructured":"Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet 2001;358:903-11. doi: 10.1016\/S0140-6736(01)06075-5.","DOI":"10.1016\/S0140-6736(01)06075-5"},{"key":"ref-35","doi-asserted-by":"crossref","unstructured":"Cifuentes DJ, Rocha LG, Silva LA, Brito AC, Rueff-Barroso CR, Porto LC, et al. Decrease in oxidative stress and histological changes induced by physical exercise calibrated in rats with osteoarthritis induced by monosodium iodoacetate. Osteoarthritis Cartilage 2010;18:1088-95. doi: 10.1016\/j.joca.2010.04.004.","DOI":"10.1016\/j.joca.2010.04.004"},{"key":"ref-36","doi-asserted-by":"crossref","unstructured":"Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006;69:562-73. doi: 10.1016\/j.cardiores.2005.12.002.","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"ref-37","doi-asserted-by":"crossref","unstructured":"Tong KM, Shieh DC, Chen CP, Tzeng CY, Wang SP, Huang KC, et al. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB\/ p300 binding in human synovial fibroblasts. 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