{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:49:37Z","timestamp":1782226177255,"version":"3.54.5"},"reference-count":17,"publisher":"Galenos Yayinevi","issue":"4","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk Gogus Kalp Dama"],"accepted":{"date-parts":[[2023,4,2]]},"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study aims to investigate the role of neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and systemic inflammation response index in patients with myasthenia gravis, thymomas and thymic hyperplasia and to identify the relationship between the inflammation response and disease activity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Between January 2010 and December 2018, a total of 97 patients (71 males, 26 females; mean age: 36.7\u00b116.3 years; range, 15 to 76 years) who underwent extended thymectomy with the diagnosis of myasthenia gravis were retrospectively analyzed. The patients were divided into two groups as the patient group (n=42) and the control group (n=55). Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyteto-lymphocyte ratio, and systemic inflammation response index were measured one day prior to and one month after surgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The patients with thymoma were older with a higher mean pre-systemic inflammation response index value. Preoperative systemic inflammation response index, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly higher in patients with thymoma. A preoperative systemic inflammation response index value of less than 0.62 was accepted to indicate thymic hyperplasia and a postoperative systemic inflammation response index value higher than 2.94 was indicative of thymoma. In myasthenic patients whose steroid dose was increased and\/or remained the same at the first month after surgery, postoperative monocyte-to-lymphocyte ratio and systemic inflammation response index values were found to be higher compared to preoperative values (p=0.006 and p=0.032, respectively). Patients whose pyridostigmine dose was increased and\/or remained the same had significantly higher systemic inflammation response index values postoperatively (p=0.029).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The precise cut-off values of systemic inflammation response index may be helpful for the surgeon to predict the surgical outcome and post-systemic inflammation response index may be a predictive marker for estimating postoperative treatment changes.\n                  <\/jats:p>","DOI":"10.5606\/tgkdc.dergisi.2023.24588","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T09:19:58Z","timestamp":1701940798000},"page":"547-555","source":"Crossref","is-referenced-by-count":5,"title":["The change of systemic inflammation response index in the treatment of patients with myasthenia gravis undergoing thymectomy: A retrospective, follow-up study"],"prefix":"10.4274","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-4832","authenticated-orcid":false,"given":"Fatma","family":"\u0130lknur Ulug\u00fcn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-8284","authenticated-orcid":false,"given":"Nezih","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Kurup A, Loehrer PJ Sr. Thymoma and thymic carcinoma: Therapeutic approaches. 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