{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:48:17Z","timestamp":1787032097720,"version":"build-2736575974"},"reference-count":23,"publisher":"Galenos Yayinevi","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk Gogus Kalp Dama"],"accepted":{"date-parts":[[2025,8,22]]},"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study aims to evaluate our experience with magnetic resonance lymphangiography in single-ventricle congenital heart disease patients and to examine the association between imaging findings and clinical outcomes and postoperative outcomes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Between November 2022 and May 2025, a total of 33 patients (22 males, 11 females; median age: 44 months; range, 37 to 57.5 months) with single-ventricle congenital heart disease who underwent T2-weighted magnetic resonance lymphangiography at our center were retrospectively analyzed. The T2-weighted sequences were chosen for their high-resolution depiction of lymphatic structures without the need for contrast agents. The imaging findings were analyzed for preoperative risk evaluation or suspected postoperative lymphatic complications.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Lymphatic abnormalities were categorized into types 1 to 3 based on the extent and distribution of T2-hyperintense signals. No patients in this cohort exhibited type 4 abnormalities. Among 33 patients, 11 (33%) were classified as type 1, 18 (55%) as type 2, and four (12%) as type 3. Although not statistically significant, patients with type 3 patterns had the longest median pleural effusion duration (27.5 days) and length of hospital stay (61 days). One patient showed early postoperative progression from type 2 to type 3, which resolved clinically and radiologically after fenestration ballooning. In the late period, two patients developed protein-losing enteropathy, and one had Fontan failure.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Magnetic resonance lymphangiography provides critical information about structural lymphatic abnormalities. It also aids risk stratification prior to the Fontan procedure and guides individualized management of postoperative complications, ultimately guiding treatment and improving outcomes.\n                  <\/jats:p>","DOI":"10.5606\/tgkdc.dergisi.2025.28290","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:39:55Z","timestamp":1762857595000},"page":"470-478","source":"Crossref","is-referenced-by-count":1,"title":["Lymphatic evaluation with magnetic resonance lymphangiography in Fontan patients: Our single-center experience"],"prefix":"10.4274","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5360-7044","authenticated-orcid":false,"given":"Demet","family":"Kangel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-0620","authenticated-orcid":false,"given":"Serap","family":"Ba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-9090","authenticated-orcid":false,"given":"Ali","family":"Naz\u0131m G\u00fczelba\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6228-6556","authenticated-orcid":false,"given":"Halise","family":"Zeynep Gen\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-734X","authenticated-orcid":false,"given":"Ezgi","family":"Diren\u00e7 Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-3262","authenticated-orcid":false,"given":"Ali","family":"Can Hatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-0635","authenticated-orcid":false,"given":"\u0130brahim","family":"Cansaran Tan\u0131d\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-3269","authenticated-orcid":false,"given":"Erkut","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-900. doi: 10.1016\/ s0735-1097(02)01886-7.","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Biko DM, DeWitt AG, Pinto EM, Morrison RE, Johnstone JA, Griffis H, et al. MRI evaluation of lymphatic abnormalities in the neck and thorax after Fontan surgery: Relationship with outcome. Radiology 2019;291:774-80. doi: 10.1148\/ radiol.2019180877.","DOI":"10.1148\/radiol.2019180877"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Itkin M, Nadolski GJ. Modern techniques of lymphangiography and interventions: Current status and future development. Cardiovasc Intervent Radiol 2018;41:366-76. doi: 10.1007\/ s00270-017-1863-2.","DOI":"10.1007\/s00270-017-1863-2"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Collins JD, Thompson SM. Noncontrast MR lymphangiography to identify progression of lymphatic abnormalities over the course of Fontan completion. Radiol Cardiothorac Imaging 2024;6:e240201. doi: 10.1148\/ ryct.240201.","DOI":"10.1148\/ryct.240201"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Schroeder C, Moosmann J, Cesnjevar R, Purbojo A, Rompel O, Dittrich S. A classification of abdominal lymphatic perfusion patterns after Fontan surgery. Eur J Cardiothorac Surg 2022;62:ezac103. doi: 10.1093\/ejcts\/ezac103.","DOI":"10.1093\/ejcts\/ezac103"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Dori Y, Keller MS, Fogel MA, Rome JJ, Whitehead KK, Harris MA, et al. MRI of lymphatic abnormalities after functional single-ventricle palliation surgery. AJR Am J Roentgenol 2014;203:426-31. doi: 10.2214\/AJR.13.11797.","DOI":"10.2214\/AJR.13.11797"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, et al. Percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart disease. Circulation 2016;133:1160-70. doi: 10.1161\/ CIRCULATIONAHA.115.019710.","DOI":"10.1161\/CIRCULATIONAHA.115.019710"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Moosmann J, Schroeder C, Rompel O, Purbojo A, Dittrich S. Serial T2-weighted thoracic and abdominal lymphatic imaging in Fontan patients-new insights into dynamics of lymphatic abnormalities after total cavopulmonary connection. J Cardiovasc Dev Dis 2022;9:138. doi: 10.3390\/ jcdd9050138.","DOI":"10.3390\/jcdd9050138"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Ghosh RM, Griffis HM, Glatz AC, Rome JJ, Smith CL, Gillespie MJ, et al. Prevalence and cause of early Fontan complications: Does the lymphatic circulation play a role? 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J Magn Reson Imaging 2021;53:1766-90. doi: 10.1002\/jmri.27542","DOI":"10.1002\/jmri.27542"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Arriv\u00e9 L, Monnier-Cholley L, Cazzagon N, Wendum D, Chambenois E, El Mouhadi S. Non-contrast MR lymphography of the lymphatic system of the liver. Eur Radiol 2019;29:5879-88. doi: 10.1007\/s00330-019-06151-6.","DOI":"10.1007\/s00330-019-06151-6"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Negm AS, Collins JD, Bendel EC, Takahashi E, Knavel Koepsel EM, Gehling KJ, et al. MR lymphangiography in lymphatic disorders: Clinical applications, institutional experience, and practice development. Radiographics 2024;44:e230075. doi: 10.1148\/rg.230075.","DOI":"10.1148\/rg.230075"},{"key":"ref-15","doi-asserted-by":"crossref","unstructured":"Ramirez-Suarez KI, Tierradentro-Garcia LO, Stern JA, Dori Y, Escobar FA, Otero HJ, et al. State-of-the-art imaging for lymphatic evaluation in children. Pediatr Radiol 2023;53:1380-90. doi: 10.1007\/s00247-022-05469-6.","DOI":"10.1007\/s00247-022-05469-6"},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Kristensen R, Kelly B, Kim E, Dori Y, Hjortdal VE. Lymphatic abnormalities on magnetic resonance imaging in single-ventricle congenital heart defects before glenn operation. J Am Heart Assoc 2023;12:e029376. doi: 10.1161\/ JAHA.123.029376.","DOI":"10.1161\/JAHA.123.029376"},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Biko DM, Smith CL, Otero HJ, Saul D, White AM, DeWitt A, et al. Intrahepatic dynamic contrast MR lymphangiography: Initial experience with a new technique for the assessment of liver lymphatics. Eur Radiol 2019;29:5190-6. doi: 10.1007\/ s00330-019-06112-z.","DOI":"10.1007\/s00330-019-06112-z"},{"key":"ref-18","doi-asserted-by":"crossref","unstructured":"Dori Y, Smith CL, DeWitt AG, Srinivasan A, Krishnamurthy G, Escobar FA, et al. Intramesenteric dynamic contrast pediatric MR lymphangiography: Initial experience and comparison with intranodal and intrahepatic MR lymphangiography. Eur Radiol 2020;30:5777-84. doi: 10.1007\/s00330-020-06949-9.","DOI":"10.1007\/s00330-020-06949-9"},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Chavhan GB, Amaral JG, Temple M, Itkin M. MR lymphangiography in children: Technique and potential applications. Radiographics 2017;37:1775-90. doi: 10.1148\/ rg.2017170014.","DOI":"10.1148\/rg.2017170014"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"Bauer C, Scala M, Sekyra P, Fellner F, Tulzer G. Noncontrast MR lymphography and intranodal dynamic contrast MR lymphangiography in children with congenital heart disease-imaging findings as well as impact on patient management and outcome. Int J Mol Sci 2023;24:14827. doi: 10.3390\/ijms241914827.","DOI":"10.3390\/ijms241914827"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Kelly B, Mohanakumar S, Ford B, Smith CL, Pinto E, Biko DM, et al. Sequential MRI evaluation of lymphatic abnormalities over the course of Fontan completion. Radiol Cardiothorac Imaging 2024;6:e230315. doi: 10.1148\/ ryct.230315.","DOI":"10.1148\/ryct.230315"},{"key":"ref-22","doi-asserted-by":"crossref","unstructured":"Vaikom House A, David D, Aguet J, Dipchand AI, Honjo O, Jean-St-Michel E, et al. Quantification of lymphatic burden in patients with Fontan circulation by T2 MR lymphangiography and associations with adverse Fontan status. Eur Heart J Cardiovasc Imaging 2023;24:241-9. doi: 10.1093\/ehjci\/jeac216.","DOI":"10.1093\/ehjci\/jeac216"},{"key":"ref-23","doi-asserted-by":"crossref","unstructured":"Dori Y, Smith CL. Lymphatic disorders in patients with single ventricle heart disease. 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