{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:51:45Z","timestamp":1787619105219,"version":"build-2736575974"},"reference-count":50,"publisher":"The Korean Society of Environmental Health and Toxicology","issue":"3","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u03afa"}],"content-domain":{"domain":["eaht.org"],"crossmark-restriction":true},"short-container-title":["Environ Anal Health Toxicol"],"abstract":"<jats:p>Previous research on the well-known environmental pollutant fluoride has demonstrated that fluoride exposure can lead to oxidative stress-related male infertility. Obesity is another public health issue that has a detrimental impact on male fertility. Previously, findings on fluoride toxicity in high-fat diet (HFD) conditions associated with oxidative stress have been evidenced. This study aimed to evaluate the impact of subchronic fluoride exposure (5 mg\/kg) plus a HFD on testicular alteration in Wistar rats. Animals were divided into four groups (control, HFD, fluoride, and fluoride 5 mg\/kg plus HFD). The HFD contained a 50% kcal increase in fat (saturated fat), after 90 days of co-exposure to fluoride plus HFD, the animals showed a significant decrease in the adiposity index. The co-exposed group showed oxidative damage assessed through decreased glutathione (GSH) concentration (p &lt; 0.0001), increased concentrations of malondialdehyde (MDA) (p &lt; 0.0001), and the oxidation of proteins (p &lt; 0.0001) vs the control group. Finally, testicular histology exhibited a reduction in spermatogonia and spermatocytes. The results of the study indicate that under these conditions, subchronic co-exposure to fluoride under HFD conditions could protect against the accumulation of epididymal fat, however, oxidative alteration at the testicular level is maintained.<\/jats:p>","DOI":"10.5620\/eaht.2024023","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T06:30:14Z","timestamp":1720161014000},"page":"e2024023","update-policy":"https:\/\/doi.org\/10.5620\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of fluoride-induced testicular alteration in rats fed a high-fat diet"],"prefix":"10.5620","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-8080","authenticated-orcid":true,"given":"Manuel","family":"S\u00e1nchez-Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9129-1161","authenticated-orcid":true,"given":"Itziar","family":"Hern\u00e1ndez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-6350","authenticated-orcid":true,"given":"Eduardo Osiris","family":"Madrigal-Santill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1295-5959","authenticated-orcid":true,"given":"Kevin Francisco","family":"Flores-Elizalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-3693","authenticated-orcid":true,"given":"Jeannett Alejandra","family":"Izquierdo-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3578","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/10643389.2020.1807452"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199082"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16040564"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5620\/eaht.2022016"},{"key":"ref5","volume-title":"","author":"Gupta","year":"2016"},{"key":"ref6","volume-title":""},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22153"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0013-9351(03)00059-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-015-0464-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02687-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31940-x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.08.015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03049"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.10.010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1405-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.03.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1099-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01882-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706978"},{"key":"ref21","volume-title":""},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12827"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000417"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/and.13617"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/srep43475"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158121"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/190945"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740011201"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1600"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(79)90289-7"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86141-h"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(78)52032-6"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1159\/000321657"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0642-2"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02857-1"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109558"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1542-4"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075343"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020306"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1181-1"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2020.05.009"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41291-2"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.120321"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112506"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5269380"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-007-0036-6"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.03.045"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0641"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.05.001"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.06.107"}],"container-title":["Environmental Analysis Health and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eaht.org\/upload\/pdf\/eaht-39-3-e2024023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eaht.org\/journal\/view.php?doi=10.5620\/eaht.2024023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eaht.org\/upload\/pdf\/eaht-39-3-e2024023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T23:11:00Z","timestamp":1731539460000},"score":1,"resource":{"primary":{"URL":"http:\/\/eaht.org\/journal\/view.php?doi=10.5620\/eaht.2024023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5620\/eaht.2024023","relation":{},"ISSN":["2671-9525"],"issn-type":[{"value":"2671-9525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]},"assertion":[{"value":"2023-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}