{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:03:37Z","timestamp":1789488217090,"version":"build-2803163510"},"reference-count":6,"publisher":"Department of Medicine, Warren Alpert Medical School at Brown University","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Toxic megacolon is a severe complication of ulcerative colitis characterized by extreme dilation of the colon, often leading to life-threatening outcomes. It typically presents with symptoms such as abdominal distension, severe pain, fever, and signs of systemic toxicity. We present a case of perforated toxic megacolon in a middle-aged woman with a new diagnosis of ulcerative colitis that was refractory to corticosteroids and biologic therapy. Early recognition and treatment are crucial to reduce morbidity and mortality associated with this potentially fatal condition.<\/jats:p>","DOI":"10.56305\/001c.124818","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T11:34:28Z","timestamp":1729856068000},"source":"Crossref","is-referenced-by-count":3,"title":["Perforated Toxic Megacolon: The Dreaded Complication in Ulcerative Colitis"],"prefix":"10.56305","volume":"3","author":[{"given":"Quynh-Lan","family":"Dao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University","department":["Department of Medicine"]},{"name":"Brown University Health","department":["Division of Hospital Medicine, Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatmaelzahraa","family":"Hammad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University","department":["Department of Medicine"]},{"name":"Brown University Health","department":["Division of Hospital Medicine, Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame","family":"Dapaah-Afriyie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University","department":["Department of Medicine"]},{"name":"Brown University Health","department":["Division of Hospital Medicine, Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"35509","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/s0899-7071(01)00330-8","article-title":"Toxic Megacolon: Role of CT in Evaluation and Detection of Complications","volume":"25","author":"M. 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Holvoet","year":"2021","journal-title":"Clin Exp Gastroenterol"}],"container-title":["Journal of Brown Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bhm.scholasticahq.com\/article\/124818-perforated-toxic-megacolon-the-dreaded-complication-in-ulcerative-colitis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:16:17Z","timestamp":1789485377000},"score":1,"resource":{"primary":{"URL":"https:\/\/bhm.scholasticahq.com\/article\/124818-perforated-toxic-megacolon-the-dreaded-complication-in-ulcerative-colitis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.56305\/001c.124818","relation":{},"ISSN":["2994-5593"],"issn-type":[{"value":"2994-5593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}