{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:48Z","timestamp":1792009548833,"version":"4.4.0"},"reference-count":6,"publisher":"Department of Medicine, Warren Alpert Medical School at Brown University","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Calciphylaxis is a rare and life-threatening condition characterized by vascular calcification and thrombosis, typically seen in patients with end-stage renal disease but also associated with long-term warfarin use in non-uremic patients. We present the case of a 78-year-old woman with a mechanical aortic valve on chronic warfarin therapy who developed progressive, painful necrotic skin ulcerations over ten months. Skin biopsy confirmed warfarin-induced non-uremic calciphylaxis. Following shared decision-making, warfarin was discontinued and replaced with low molecular weight heparin, and intravenous sodium thiosulfate was initiated. This case underscores the importance of recognizing non-uremic calciphylaxis in warfarin-treated patients and highlights the need for early diagnosis, multidisciplinary management, and shared decision-making to balance the risks of anticoagulation against serious complications like calciphylaxis.<\/jats:p>","DOI":"10.56305\/001c.138462","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T11:26:53Z","timestamp":1751369213000},"source":"Crossref","is-referenced-by-count":2,"title":["Warfarin Induced Non-Uremic Calciphylaxis"],"prefix":"10.56305","volume":"4","author":[{"given":"Michael","family":"Kanan","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9281-8138","authenticated-orcid":true,"given":"Farzana","family":"Hoque","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine","department":["Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"35509","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"1","key":"ref1","first-page":"1","article-title":"Idiopathic calciphylaxis with cutaneous necrosis: a case report","volume":"8","author":"W. Tang","year":"2024","journal-title":"Am J Hosp Med"},{"issue":"3","key":"ref2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1001\/jamadermatol.2016.4821","article-title":"Warfarin-Associated Nonuremic Calciphylaxis","volume":"153","author":"W. Y. Yu","year":"2017","journal-title":"JAMA Dermatol"},{"issue":"8","key":"ref3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.12968\/jowc.2022.0218","article-title":"Warfarin-induced calciphylaxis-related skin ulceration in patients with end-stage renal disease: case report and literature review","volume":"33","author":"V. Vallini","year":"2024","journal-title":"J Wound Care"},{"issue":"4","key":"ref4","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/jcpt.12411","article-title":"Huilaja L, Turpeinen M, Tokola H, et al.","volume":"41","year":"2016","journal-title":"Journal of Clinical Pharmacy and Therapeutics"},{"issue":"4","key":"ref5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.56305\/001c.122787","article-title":"Shared Decision-Making in Patient Care: Advantages, Barriers and Potential Solutions","volume":"3","author":"F. Hoque","year":"2024","journal-title":"Brown Hospital Medicine"},{"issue":"2","key":"ref6","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1053\/j.ajkd.2022.06.011","article-title":"Calciphylaxis and Kidney Disease: A Review","volume":"81","author":"B. Gallo Marin","year":"2023","journal-title":"Am J Kidney Dis"}],"container-title":["Journal of Brown Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bhm.scholasticahq.com\/article\/138462-warfarin-induced-non-uremic-calciphylaxis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T11:26:54Z","timestamp":1751369214000},"score":1,"resource":{"primary":{"URL":"https:\/\/bhm.scholasticahq.com\/article\/138462-warfarin-induced-non-uremic-calciphylaxis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.56305\/001c.138462","relation":{},"ISSN":["2994-5593"],"issn-type":[{"value":"2994-5593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]}}}