{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:57:25Z","timestamp":1781798245331,"version":"3.54.5"},"reference-count":15,"publisher":"Department of Medicine, Warren Alpert Medical School at Brown University","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 52-year-old man with no personal or family history of bleeding presented with extensive hematomas and skin bruising following prolonged antibiotic use. Initial laboratory evaluation revealed coagulopathy, with an elevated activated partial thromboplastin time and mild anemia. Mixing studies and factor assays confirmed the diagnosis of acquired hemophilia A, characterized by low factor VIII levels and high-titer factor VIII inhibitors. The patient was initiated on corticosteroids and cyclophosphamide, leading to gradual improvement in both bleeding symptoms and coagulation parameters. Comprehensive evaluations excluded autoimmune diseases and malignancies, supporting the conclusion that the condition was linked to prolonged antibiotic use. The patient continues to be in clinical remission after targeted therapy.<\/jats:p>","DOI":"10.56305\/001c.147407","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T15:11:52Z","timestamp":1767280312000},"source":"Crossref","is-referenced-by-count":2,"title":["Post-Infectious Acquired Hemophilia A: A Case Report and Review of the Literature"],"prefix":"10.56305","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-2414","authenticated-orcid":true,"given":"Jandir Mendon\u00e7a","family":"Nicacio","sequence":"first","affiliation":[{"name":"Federal University of S\u00e3o Francisco Valley","department":["Department of Medicine"]},{"name":"University Hospital, Federal University of Vale do S\u00e3o Francisco (HU-UNIVASF\/EBSERH), Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2970-2608","authenticated-orcid":false,"given":"Christian Mangueira Monteiro","family":"de Ara\u00fajo J\u00fanior","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Francisco Valley","department":["Department of Medicine"]},{"name":"University Hospital, Federal University of Vale do S\u00e3o Francisco (HU-UNIVASF\/EBSERH), Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3682-2934","authenticated-orcid":false,"given":"Naiara de Souza","family":"Barros","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Francisco Valley","department":["Department of Medicine"]},{"name":"University Hospital, Federal University of Vale do S\u00e3o Francisco (HU-UNIVASF\/EBSERH), Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2861-9202","authenticated-orcid":false,"given":"Paulo Inoc\u00eancio da Fonseca","family":"Cufua","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Francisco Valley","department":["Department of Medicine"]},{"name":"University Hospital, Federal University of Vale do S\u00e3o Francisco (HU-UNIVASF\/EBSERH), Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5848-4883","authenticated-orcid":false,"given":"Andr\u00e9 Luis Magalh\u00e3es","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Hospital Regional Juazeiro, Juazeiro (BA), Brazil","department":["Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"35509","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"publisher","first-page":"e244748","DOI":"10.1136\/bcr-2021-244748","article-title":"Doxycycline-induced acquired haemophilia A","volume":"14","author":"E. 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