{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:44:03Z","timestamp":1785408243796,"version":"3.56.0"},"reference-count":7,"publisher":"Department of Medicine, Warren Alpert Medical School at Brown University","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Pseudohypobicarbonatemia, a falsely low serum bicarbonate level due to laboratory interference, is an underrecognized condition in clinical practice. We describe a 30-year-old patient whose metabolic panels repeatedly suggested a high\u2013anion gap metabolic acidosis, while arterial blood gas testing showed a normal bicarbonate level, ultimately attributable to severe hypertriglyceridemia. Lipid interference is well documented in the literature. Our laboratory analyzer is designed to flag lipemic specimens using a lipemia index; however, this sample was not flagged despite triglyceride concentrations above the usual cutoff. We propose that variability in the patient\u2019s specimen, which contained a heterogeneous mixture of lipid particles, altered light scattering across measurements and produced a falsely low lipemia index. Awareness of pseudohypobicarbonatemia can help clinicians promptly recognize reversible causes of lipemia or other forms of analytical interference.<\/jats:p>","DOI":"10.56305\/001c.157877","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:51:35Z","timestamp":1775062295000},"source":"Crossref","is-referenced-by-count":0,"title":["Pseudohypobicarbonatemia: Discordant Bicarbonate Values in Serum and Arterial Samples"],"prefix":"10.56305","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8070-157X","authenticated-orcid":true,"given":"Ela-Anamaria","family":"Moisa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mgpsx86","id-type":"ROR","asserted-by":"publisher"}],"name":"SouthCoast Health","department":["Division of Hospital Medicine, St. Luke\u2019s Hospital, New Bedford MA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Shunmugam Veluswamy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mgpsx86","id-type":"ROR","asserted-by":"publisher"}],"name":"SouthCoast Health","department":["Division of Hospital Medicine, St. Luke\u2019s Hospital, New Bedford MA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Viveiros","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mgpsx86","id-type":"ROR","asserted-by":"publisher"}],"name":"SouthCoast Health","department":["St. Luke\u2019s Hospital Chemistry & Molecular Diagnostic Laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Maltseva","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mgpsx86","id-type":"ROR","asserted-by":"publisher"}],"name":"SouthCoast Health","department":["Division of Hospital Medicine, St. Luke\u2019s Hospital, New Bedford MA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Patel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mgpsx86","id-type":"ROR","asserted-by":"publisher"}],"name":"SouthCoast Health","department":["Division of Nephrology St. Luke\u2019s Hospital, New Bedford MA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani","family":"Hackner","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mgpsx86","id-type":"ROR","asserted-by":"publisher"}],"name":"SouthCoast Health","department":[". Division of Pulmonary\/Critical Care Medicine, Department of Medicine, Southcoast Hospitals Group, Fall River, MA."]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"35509","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1053\/j.ajkd.2011.06.003","article-title":"Pseudohypobicarbonatemia caused by an endogenous assay interferent: a new entity","volume":"58","author":"P. Goldwasser","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"ref2","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3109\/0886022X.2014.917945","article-title":"Factitious hypobicarbonatemia associated with profound hyperlipidemia","volume":"36","author":"S. I. 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