{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:18:46Z","timestamp":1739942326110,"version":"3.37.3"},"reference-count":15,"publisher":"Department of Medicine, Warren Alpert Medical School at Brown University","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Amyloidosis is often known as \u201cthe great imitator,\u201d as the clinical diagnosis of AL amyloidosis is quite challenging and often delayed, given multi-organ involvement. We present a unique case of an elderly male who presented with an eight-month history of progressive lower extremity edema and dyspnea and was admitted for syncope, anasarca, and severe dyspnea. He was diagnosed with renal failure, nephrotic syndrome, a large renal mass, and severe non-ischemic cardiomyopathy. A renal resection was performed, and renal cell carcinoma (RCC) and light chain (AL) amyloidosis were diagnosed.<\/jats:p>","DOI":"10.56305\/001c.57746","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T01:21:57Z","timestamp":1672449717000},"source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Presentation of Light Chain Amyloidosis and Renal Cell Carcinoma in an Elderly Male : A Case Report and Review of the Literature"],"prefix":"10.56305","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2336-139X","authenticated-orcid":false,"given":"Hien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Camp Springs Medical Center, Kaiser Permanente, Temple Hills, MD, USA","department":["Department of Internal Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meron","family":"Dinsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"35509","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.3332\/ecancer.2020.1156","article-title":"Advanced systemic amyloidosis secondary to metastatic renal cell carcinoma","volume":"14","author":"Maria Asunci\u00f3n Algarra","year":"2020","journal-title":"Ecancermedicalscience","ISSN":"https:\/\/id.crossref.org\/issn\/1754-6605","issn-type":"print"},{"issue":"1-3","key":"ref2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s12026-014-8528-x","article-title":"Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma","volume":"59","author":"Timothy R. Rosean","year":"2014","journal-title":"Immunologic Research","ISSN":"https:\/\/id.crossref.org\/issn\/0257-277X","issn-type":"print"},{"issue":"19","key":"ref3","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.1182\/blood-2011-11-390930","article-title":"Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis","volume":"119","author":"Joseph R. Mikhael","year":"2012","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"19","key":"ref4","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1182\/blood-2011-10-388462","article-title":"Cyclophosphamide, bortezomib, and dexamethasone therapy in AL amyloidosis is associated with high clonal response rates and prolonged progression-free survival","volume":"119","author":"Christopher P. Venner","year":"2012","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"4","key":"ref5","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1159\/000507724","article-title":"Nonchemotherapy Treatment of Immunoglobulin Light Chain Amyloidosis","volume":"143","author":"Layla Van Doren","year":"2020","journal-title":"Acta Haematologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5792","issn-type":"print"},{"issue":"1","key":"ref6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1182\/blood.2019004460","article-title":"Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of ANDROMEDA","volume":"136","author":"Giovanni Palladini","year":"2020","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2585","article-title":"Simultaneous Clinical Presentation of Renal Cell Carcinoma and Immunoglobulin Light Chain Amyloidosis","volume":"6;10(5):e2585","author":"Bhanu Prasad","year":"2018","journal-title":"Cureus","ISSN":"https:\/\/id.crossref.org\/issn\/2168-8184","issn-type":"print"},{"issue":"1","key":"ref8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1001\/jama.2020.5493","article-title":"Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review","volume":"324","author":"Morie A. Gertz","year":"2020","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"12","key":"ref9","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","article-title":"AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy","volume":"68","author":"Rodney H. Falk","year":"2016","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"1","key":"ref10","doi-asserted-by":"publisher","first-page":"e2018022","DOI":"10.4084\/mjhid.2018.022","article-title":"Light Chain Amyloidosis","volume":"10","author":"Paolo Milani","year":"2018","journal-title":"Mediterranean Journal of Hematology and Infectious Diseases","ISSN":"https:\/\/id.crossref.org\/issn\/2035-3006","issn-type":"print"},{"issue":"1","key":"ref11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41572-018-0034-3","article-title":"Systemic immunoglobulin light chain amyloidosis","volume":"4","author":"Giampaolo Merlini","year":"2018","journal-title":"Nature Reviews Disease Primers","ISSN":"https:\/\/id.crossref.org\/issn\/2056-676X","issn-type":"print"},{"issue":"4","key":"ref12","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000506617","article-title":"When to Suspect a Diagnosis of Amyloidosis","volume":"143","author":"Iuliana Vaxman","year":"2020","journal-title":"Acta Haematologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5792","issn-type":"print"},{"issue":"4","key":"ref13","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1159\/000506696","article-title":"The Pathology of Amyloidosis in Classification: A Review","volume":"143","author":"Maria M. Picken","year":"2020","journal-title":"Acta Haematologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5792","issn-type":"print"},{"issue":"10","key":"ref14","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/clc.23426","article-title":"Electrocardiographic parameters and prognosis of renal light chain amyloidosis","volume":"43","author":"Huixian Li","year":"2020","journal-title":"Clinical Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0160-9289","issn-type":"print"},{"issue":"6","key":"ref15","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s12094-019-02192-x","article-title":"Prognostic role of interleukin-6 in renal cell carcinoma: a meta-analysis","volume":"22","author":"Y. Wang","year":"2020","journal-title":"Clinical and Translational Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1699-048X","issn-type":"print"}],"container-title":["Journal of Brown Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bhm.scholasticahq.com\/article\/57746-concurrent-presentation-of-light-chain-amyloidosis-and-renal-cell-carcinoma-in-an-elderly-male-a-case-report-and-review-of-the-literature","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:11:55Z","timestamp":1739902315000},"score":1,"resource":{"primary":{"URL":"https:\/\/bhm.scholasticahq.com\/article\/57746-concurrent-presentation-of-light-chain-amyloidosis-and-renal-cell-carcinoma-in-an-elderly-male-a-case-report-and-review-of-the-literature"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.56305\/001c.57746","relation":{},"ISSN":["2994-5593"],"issn-type":[{"type":"electronic","value":"2994-5593"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}