{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:20:26Z","timestamp":1739942426334,"version":"3.37.3"},"reference-count":5,"publisher":"Department of Medicine, Warren Alpert Medical School at Brown University","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hypercalcemia is typically associated with primary hyperparathyroidism, malignancy, vitamin D intoxication, and granulomatous disease; however, it can also be associated with a neuroendocrine tumor that secretes vasoactive intestinal polypeptide (VIP). A 74-year-old woman with a history of hypothyroidism and nephrolithiasis presented to her primary care physician with a chief complaint of diarrhea and was found to have mild hypercalcemia. A Hypercalcemia workup was initiated, and the patient was ultimately found to have elevated VIP. Although a discrete pancreatic mass was not identified, an endoscopic ultrasound with fine needle aspiration revealed a VIPoma. She was then referred to hepatobiliary surgery for the removal of the tumor. As VIPoma has a poor prognosis, early recognition and treatment are essential for improving patient outcomes.<\/jats:p>","DOI":"10.56305\/001c.73720","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T19:16:20Z","timestamp":1680549380000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypercalcemia as the Presenting Finding in VIPoma"],"prefix":"10.56305","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-0829","authenticated-orcid":false,"given":"Olivia P","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherehan","family":"Zada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago B","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satya","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"35509","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.14740\/jmc3535","article-title":"Pancreatic VIPoma as a Differential Diagnosis in Chronic Pediatric Diarrhea: A Case Report and Review of the Literature","volume":"12","author":"Carolina Bonilla Gonzalez","year":"2021","journal-title":"Journal of Medical Cases","ISSN":"https:\/\/id.crossref.org\/issn\/1923-4155","issn-type":"print"},{"key":"ref2","series-title":"StatPearls [Internet]","article-title":"ViPoma","author":"S. Sandhu","year":"2022"},{"issue":"8","key":"ref3","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1210\/jcem.80.8.7629220","article-title":"Clinical review 72: diagnosis and management of functioning islet cell tumors.","volume":"80","author":"R R Perry","year":"1995","journal-title":"The Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"9","key":"ref4","doi-asserted-by":"publisher","first-page":"R423","DOI":"10.1530\/erc-16-0200","article-title":"Medical management of secretory syndromes related to gastroenteropancreatic neuroendocrine tumours","volume":"23","author":"Georgios K Dimitriadis","year":"2016","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"6","key":"ref5","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/jso.22118","article-title":"Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes","volume":"105","author":"Christina L. Roland","year":"2012","journal-title":"Journal of Surgical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-4790","issn-type":"print"}],"container-title":["Journal of Brown Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bhm.scholasticahq.com\/article\/73720-hypercalcemia-as-the-presenting-finding-in-vipoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:37:03Z","timestamp":1739903823000},"score":1,"resource":{"primary":{"URL":"https:\/\/bhm.scholasticahq.com\/article\/73720-hypercalcemia-as-the-presenting-finding-in-vipoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.56305\/001c.73720","relation":{},"ISSN":["2994-5593"],"issn-type":[{"type":"electronic","value":"2994-5593"}],"subject":[],"published":{"date-parts":[[2023,4,1]]}}}