{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:31:52Z","timestamp":1770463912232,"version":"3.49.0"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>&lt;p&gt;&lt;strong&gt;Objective&lt;\/strong&gt;. To evaluate changes in the expression of tumor necrosis \u00a0factor-\u03b1 in patients with rheumatoid arthritis submitted to phototherapy.\u00a0&lt;strong&gt;Materials and methods&lt;\/strong&gt;. This was an open label study, enrolling\u00a0ten patients. The phototherapy scheme within a range of 425 to 650\u00a0nm, 11.33 Joules\/cm2, 30 cm above the chest was as follows: a) 45-min\u00a0daily sessions from Monday to Friday for 2 to 3 months; b) three, 45-min weekly sessions for 1 to 2 months; c) twice weekly 45-min sessions\u00a0for 1 to 2 months, and d) one weekly session for 1 to 2 months\u00a0until completion. Erythrocyte sedimentation rate, C-reactive protein\u00a0and rheumatoid factor were measured in peripheral blood and tumor\u00a0necrosis factor-\u03b1, interleukin-1\u03b2, and interleukin-10 in leukocytes by\u00a0quantitative real-time Reverse transcriptase-Polymerase chain reaction.\u00a0In all the patients the next indexes: Karnofsky scale, Rheumatoid\u00a0Arthritis-specific quality of life instrument, Steinbrocker Functional\u00a0Capacity Rating and the Visual Analog Scale were evaluated. &lt;strong&gt;Results&lt;\/strong&gt;.\u00a0Erythrocyte sedimentation rate, C-reactive protein, and rheumatoid\u00a0factor declined notoriously after the indicated sessions. In gene expression,\u00a0there was a tendency in tumor necrosis factor-\u03b1 to decrease\u00a0after 1 month, from 24.5\u00b111.4 to 18\u00b19.2 relative units, without reaching\u00a0a significant statistical difference. The four tested indexes showed\u00a0improvement. &lt;strong&gt;Conclusion&lt;\/strong&gt;. Phototherapy appears to be a plausible\u00a0complementary option to reduce the inflammatory component in \u00a0rheumatoid arthritis.&lt;\/p&gt;<\/jats:p>","DOI":"10.5644\/ama2006-124.137","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:51:00Z","timestamp":1666007460000},"page":"102","source":"Crossref","is-referenced-by-count":4,"title":["Trends of inflammatory markers and cytokines after one month of phototherapy in patients with rheumatoid arthritis"],"prefix":"10.5644","volume":"44","author":[{"given":"Jos\u00e9 Meneses","family":"Calder\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Gonz\u00e1lez S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo Aburto","family":"Huacuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arely Sarai Alonso","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Del Carmen Col\u00edn","family":"Ferreyra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo Mendieta","family":"Zer\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3666","published-online":{"date-parts":[[2015,12,18]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/viewFile\/249\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:51:01Z","timestamp":1666007461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/view\/249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,12,18]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.137","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,18]]}}}