{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:34:03Z","timestamp":1773740043793,"version":"3.50.1"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>Abstract In this review, we discuss the latest developments in research pertaining to virus-induced asthma exacerbations and consider recent advances in treatment options. Asthma is a chronic disease of the airways that continues to impose a substantial clinical burden worldwide. Asthma exacerbations, characterised by an acute deterioration in respiratory symptoms and airflow ob- struction, are associated with significant morbidity and mortality. These episodes are most commonly triggered by respiratory virus infections. The mechanisms underlying the pathogenesis of virus-induced exacerbations have been the focus of extensive biomedical research. Developing a robust understanding of the interplay between respiratory viruses and the host immune response will be critical for developing more efficacious, targeted therapies for exacerbations.Conclusion. There has been sig- nificant recent progress in our understanding of the mechanisms underlying virus-induced airway inflammation in asthma and these advances will underpin the development of future clinical therapies.<\/jats:p>","DOI":"10.5644\/ama2006-124.292","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:13:49Z","timestamp":1666005229000},"page":"130-143","source":"Crossref","is-referenced-by-count":10,"title":["Respiratory Virus Infections in Asthma: Research Developments and Therapeutic Advances"],"prefix":"10.5644","volume":"49","author":[{"given":"Kartik","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aran","family":"Singanayagam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian L.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3666","published-online":{"date-parts":[[2020,11,11]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/ama.ba\/index.php\/ama\/article\/download\/410\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ama.ba\/index.php\/ama\/article\/download\/410\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:08:48Z","timestamp":1712048928000},"score":1,"resource":{"primary":{"URL":"https:\/\/ama.ba\/index.php\/ama\/article\/view\/410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,11,11]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.292","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,11]]}}}