{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:27:55Z","timestamp":1777620475185,"version":"3.51.4"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>&lt;p&gt;&lt;strong&gt;Objective&lt;\/strong&gt;. This study aimed to evaluate the efficacy and safety of lysozyme-based oral antiseptic in the therapy of non-infectious sore throat in teachers.&lt;\/p&gt;&lt;p&gt;&lt;strong&gt; Materials and Methods&lt;\/strong&gt;. A non-interventional, prospective, pilot study was conducted with two examinations. The first was performed as part of a general medical examination. If a non-infectious sore throat was confirmed by clinical checkup and all other inclusion and non-exclusion criteria confirmed, patients were offered to be enrolled in the study. After signing the informed consent form, patients were advised to use lysozyme-based lozenges, six times a day, for a period of five days. A telephone call follow-up examination was performed within 24 hours from the therapy completion.&lt;\/p&gt;&lt;p&gt;&lt;strong&gt; Results&lt;\/strong&gt;. This was a pilot study involving 25 adult patients of both genders. Lysozyme-based lozenges showed positive effects in relieving the symptoms of non-infectious sore throat in teachers. At the same time, the lozenges showed excellent tolerability, and no side effects were reported during the study. 92% of patients confirmed they would take the same medicine again due to the same problem. Conclusion. The results of this \u201cproof-of-concept\u201d study indicated that lysozyme-based antiseptic could be effective and safe in the treatment of non-infectious sore throat in teachers and should be further evaluated as treatment option in this condition.&lt;\/p&gt;<\/jats:p>","DOI":"10.5644\/ama2006-124.364","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T09:39:32Z","timestamp":1665653972000},"page":"1","source":"Crossref","is-referenced-by-count":1,"title":["Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozyme-based Therapy in Patients with Noninfectious Sore Throat"],"prefix":"10.5644","volume":"51","author":[{"given":"Selma","family":"Karaka\u0161","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u017eenana","family":"Huduti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meliha","family":"Mehi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"\u0160ukalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasna","family":"D\u017eananovi\u0107 Jaganjac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna","family":"Tanovi\u0107 Avdi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Skopljak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azra","family":"Dupovac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Sarajli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Una","family":"Glamo\u010dlija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3666","published-online":{"date-parts":[[2022,6,9]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"http:\/\/www.ama.ba\/index.php\/ama\/article\/viewFile\/483\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T09:39:33Z","timestamp":1665653973000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ama.ba\/index.php\/ama\/article\/view\/483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,6,9]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.364","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,9]]}}}