{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:34:31Z","timestamp":1775727271426,"version":"3.50.1"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>Objective. To synthesize current evidence on the diagnosis, histopathological evaluation, clinical features, management, and follow-up of appendiceal neuroendocrine tumors (aNETs) in children and adolescents, and to outline key differences from their adult counterparts.\nBackground. Pediatric aNETs are rare gastrointestinal neoplasms that typically exhibit an indolent clinical course with minimal risk of recurrence or metastasis. Their biological and prognostic features differ from those in adults, limit- ing the applicability of adult-derived guidelines in children.\nMethods. A mini review of the current literature was conducted, focusing on epidemiology, clinical presentation, diagnostic workup, key pathological features, surgical management, and fol- low-up strategies for pediatric aNETs.\nDiscussion. Contemporary evidence supports a de-escalated, risk-adapted approach to management, with simple appendectomy being curative in most cases. Multidisciplinary Team (MDT) discussion remains critical for atypical or borderline cases requiring individualized decision-making. Differences from adult aNETs highlight the need for pediatric-specific clinical decision-making.\nConclusion. Early recognition, accurate histopathologic evaluation, and tailored surgical management are essential to optimize outcomes for children and adolescents with aNETs.\u00a0<\/jats:p>","DOI":"10.5644\/ama2006-124.496","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:55:03Z","timestamp":1770126903000},"source":"Crossref","is-referenced-by-count":0,"title":["Appendiceal Neuroendocrine Tumors in Children and Adolescents"],"prefix":"10.5644","author":[{"given":"Jelena","family":"Roganovi\u0107","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Children\u2019s Hospital Zagreb, Zagreb, Croatia"},{"name":"Faculty of Biomedicine and Drug Development, University of Rijeka, Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Virgone","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Division, University Hospital of Padua, Padua, Italy"},{"name":"Department of Women\u2019s and Children\u2019s Health, University Hospital of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Santoro","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3666","published-online":{"date-parts":[[2026,3,25]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/887\/930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/887\/930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:42:27Z","timestamp":1775724147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/view\/887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.496","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,25]]}}}