{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:46:43Z","timestamp":1777682803022,"version":"3.51.4"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>This study aimed to investigate which of the two vitamin K antagonists, warfarin or acenocoumarol, provides more\u00a0stable anticoagulation control in patients with mechanical heart valves and atrial fibrillation.\nPatients and Methods. This was aprospective, one-year clinical cohort study. In total, 73 outpatients with mechanical heart valves and atrial fibrillation who were\u00a0already treated with warfarin or acenocoumarol were recruited from the Blood Transfusion Institute of the Federation of Bosnia\u00a0and Herzegovina. The prothrombin time target values, expressed as the international normalized ratio (INR), were 2.0\u20133.0\/4.0.\u00a0Numerical data between the treatment groups were summarized descriptively.\nResults. Patients in the warfarin (N=35) and\u00a0acenocoumarol (N=38) treatment groups were similar in terms of sex, age, body mass index, body surface area, and number\u00a0of concomitant drugs known to interact with vitamin K antagonists. The number of INR measurements per patient, number\u00a0of INR measurements within the therapeutic range per patient, mean time interval between successive INR measurements,\u00a0and mean INR values across consecutive measurements were similar in both groups. However, compared to acenocoumarol,\u00a0warfarin treatment seemed to be associated with more stable anticoagulation, i.e., with a higher mean time in the therapeutic\u00a0range (TTR) (76.1\u00b124.2 vs. 69.1\u00b121.5%) and a smaller proportion of patients below all predefined TTR thresholds (&lt;60%,\u00a0&lt;65%, and &lt;70%).\nConclusion. Our unadjusted descriptive results suggested that warfarin, compared to acenocoumarol, may\u00a0provide more stable and therefore safer anticoagulation control in patients with mechanical heart valves and atrial fibrillation.\u00a0To confirm this, larger prospective clinical studies are needed in patients with mechanical heart valves with or without atrial\u00a0fibrillation.<\/jats:p>","DOI":"10.5644\/ama2006-124.497","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:00:56Z","timestamp":1773820856000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Stability of Warfarin and Acenocoumarol in Patients With MechanicalHeart Valves and Atrial Fibrillation: A One-Year Cohort Study"],"prefix":"10.5644","volume":"55","author":[{"given":"\u0160ahza","family":"Hajdari Toski\u0107","sequence":"first","affiliation":[{"name":"Department for Detection of Coagulation Disorders, Blood Transfusion Institute of the Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asija","family":"Mevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Kulo \u0106esi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3666","published-online":{"date-parts":[[2026,3,2]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/1028\/1069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/1028\/1069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:44:08Z","timestamp":1777452248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/view\/1028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.497","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}