{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:47:11Z","timestamp":1777682831958,"version":"3.51.4"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>Objective. HPV infection is a key etiological factor in cervical epithelial alterations and neoplasia. Its prevalence and cytological impact vary with age, co-infections, and screening practices. This study investigated the association between HPV infection, age, and cervical cytological findings in women from North Macedonia.\nMaterials and Methods. This cross-sectional study included 300 women aged 26\u201366 years, who were screened over a 13-month period (June 2023\u2013July 2024). The participants were divided into two age groups (26\u201336 and 37\u201366 years). All participants underwent Pap testing, HPV screening, and micro- biological evaluation. Ordinal regression analysis was used to examine the associations between age, microbial factors, and HPV positivity.\nResults. HPV prevalence was higher in the 37\u201366 group (12.33%) than in the 26\u201336 group (6.0%). However, younger age showed a stronger statistical association with HPV positivity (OR=2.10; P&lt;0.1). Cytological abnormalities, particularly LSIL\/CIN I, were more prevalent in HPV-positive participants. The use of conventional Pap smears was associated with lower HPV detection (OR=0.16; P&lt;0.05). Co-infection with Candida spp. and atrophic inflammation were inversely associated with HPV positivity.\u00a0\nConclusion. This study confirmed the association between HPV infection and cytological changes, particularly in younger age groups. These results highlight the importance of age-tailored screening approaches and support the continued use of conventional Pap smears as cost-effective tools. Integrating virological and microbiological assessments may further re- fine cervical cancer prevention strategies, particularly in transitional healthcare systems across the Western Balkans.<\/jats:p>","DOI":"10.5644\/ama2006-124.498","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:11:02Z","timestamp":1773821462000},"page":"21-29","source":"Crossref","is-referenced-by-count":0,"title":["Cervical Cytology and Age in HPV-Infected Women in North Macedonia:\u00a0A Cross-Sectional Study"],"prefix":"10.5644","volume":"55","author":[{"given":"Vjollca","family":"Shabani","sequence":"first","affiliation":[{"name":"Indusmedica Skopje \u2013 Diagnostic Laboratory for Biochemistry, Microbiology, Cytology and Histopathology, Skopje, North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mije","family":"Re\u00e7i","sequence":"additional","affiliation":[{"name":"Department of Biology \u2013 Biochemistry, Faculty of Mathematics and Natural Sciences, University of Tetova, Tetovo, North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veselievska","family":"Stojkovska","sequence":"additional","affiliation":[{"name":"University Clinic of Gynecology and Obstetrics, Medical Faculty, University \u201cSs. Cyril and Methodius\u201d, Skopje, North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3666","published-online":{"date-parts":[[2026,3,2]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/ama.ba\/index.php\/ama\/article\/download\/1030\/1071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ama.ba\/index.php\/ama\/article\/download\/1030\/1071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:44:15Z","timestamp":1777452255000},"score":1,"resource":{"primary":{"URL":"https:\/\/ama.ba\/index.php\/ama\/article\/view\/1030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.498","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}