{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:06:05Z","timestamp":1789387565885,"version":"build-2803163510"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"2","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>Objective. Infantile hemangiomas (IH) are common benign vascular tumors of infancy that typically undergo gradual spontaneous regression over several years, although a minority require treatment. Propranolol, a non-selective \u03b2-adrenergic antagonist, is the first-line therapy for complicated or high-risk IH, demonstrating both efficacy and a favorable safety profile.\nMaterials and Methods. We retrospectively analyzed 37 infants treated with oral propranolol at a single center. Patients were monitored in-hospital during treatment initiation and at regular, outpatient visits. The response was assessed using clinical measurements, ultrasonography, and standardized photographs.\nResults. Most patients had solitary lesions predominantly located in the head region. Complete regression occurred in 26 patients (70.3%) and partial regression in 11 (29.7%). Treatment duration ranged from 2 to 24 months (mean 10.1 months). Adverse events were rare and mild, including one case of hypoglycemia and one of transient somnolence.\nConclusion. Oral propranolol is a safe and effective first-line therapy for IH, particularly when initiated early during the proliferative phase.<\/jats:p>","DOI":"10.5644\/ama2006-124.502","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:22:45Z","timestamp":1779128565000},"page":"197-201","source":"Crossref","is-referenced-by-count":0,"title":["Propranolol in the Treatment of Infantile Hemangiomas: A Single-Center Experience"],"prefix":"10.5644","volume":"55","author":[{"given":"Jelena","family":"Roganovi\u0107","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Children\u2019s Hospital Zagreb, Zagreb, Croatia"},{"name":"Faculty of Biomedicine and Drug Development, University of Rijeka, Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kevri\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Hospital Centre Rijeka, Rijeka, Croatia"},{"name":"Faculty of Health Studies, University of Rijeka, Rijeka, Croatia, 5Business Department, Jadran Galenski Laboratorij, Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"\u0110or\u0111evi\u0107","sequence":"additional","affiliation":[{"name":"Business Department, Jadran Galenski Laboratorij, Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3666","published-online":{"date-parts":[[2026,5,18]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/1044\/1081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/1044\/1081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:34:42Z","timestamp":1789385682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/view\/1044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.502","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,18]]}}}