{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:06:01Z","timestamp":1789387561290,"version":"build-2803163510"},"reference-count":0,"publisher":"Academy of Sciences and Arts of Bosnia and Herzegovina","issue":"2","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ama"],"abstract":"<jats:p>Objective. Myxopapillary ependymoma (MPE) is a rare tumor of ependymal origin that commonly arises within the spinal canal. It is rather benign and slow-growing; however, it tends to recur along the central nervous system (CNS), usually after incomplete resection or tumor seeding due to surgical manipulation. Extraneural metastases of MPE are extremely rare, with only a few documented cases in the literature.\nCase Report. We describe a case of a middle-aged female patient with sacrococcy- geal MPE, which was initially misdiagnosed as a pilonidal cyst and subjected to surgical excision. Over the following years, she experienced three local recurrences in the sacrococcygeal region, which were treated with surgery and radiotherapy. Ten years after the initial excision, the patient complained of dyspnea and hemoptysis, and imaging studies revealed multiple right lung nodules. A core biopsy of a lung lesion was performed, and histopathology was consistent with metastatic MPE. The patient was started on chemotherapy with per os temozolomide and has not experienced disease progression for nearly 3 years.\nConclusion. Extraneural metastases of MPE represent an exceptionally rare and diagnostically challenging entity and should be considered in patients with a history of MPE who present with distant lesions, even years after the initial diagnosis.<\/jats:p>","DOI":"10.5644\/ama2006-124.514","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:02:30Z","timestamp":1786024950000},"page":"208-215","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Spine: A Rare Case of Myxopapillary Ependymoma With Extraneural Metastases"],"prefix":"10.5644","volume":"55","author":[{"given":"Areti","family":"Kalfoutzou","sequence":"first","affiliation":[{"name":"Second Propaedeutic Department of Internal Medicine, General University Hospital Attikon, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleopatra","family":"Rapti","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, 251 Air Force General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Sfikas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, 251 Air Force General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Bagiokou","sequence":"additional","affiliation":[{"name":"Oncology Unit, 3rd Department of Internal Medicine, Athens General Hospital of Thoracic Diseases \u201cSotiria\u201d, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Chaleplidis","sequence":"additional","affiliation":[{"name":"Department of Pathology, 251 Air Force General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Kolintzikis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Agios Savvas Cancer Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Ramfidis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, 251 Air Force General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3666","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Acta Medica Academica"],"original-title":[],"link":[{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/1051\/1088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/download\/1051\/1088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:31:57Z","timestamp":1789385517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ama.ba\/index.php\/ama\/article\/view\/1051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.5644\/ama2006-124.514","relation":{},"ISSN":["1840-2879","1840-1848"],"issn-type":[{"value":"1840-2879","type":"electronic"},{"value":"1840-1848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}