{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T01:36:35Z","timestamp":1770600995147,"version":"3.49.0"},"reference-count":40,"publisher":"Japan Oil Chemists' Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2013]]},"DOI":"10.5650\/jos.62.745","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T23:30:11Z","timestamp":1378164611000},"page":"745-754","source":"Crossref","is-referenced-by-count":7,"title":["Pioglitazone-Induced Increase in the Stearoyl-CoA Desaturation Index and Fat Accumulation in Rat Muscles Are Not Related to Lipoprotein Lipase Activity"],"prefix":"10.5650","volume":"62","author":[{"given":"Masaru","family":"Ochiai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Coen, P. M.; Goodpaster, B. H. Role of intramyocelluar lipids in human health. Trends Endocrinol. Metab. 23, 391-398 (2012).","DOI":"10.1016\/j.tem.2012.05.009"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Consitt, L. A.; Bell, J. A.; Houmard, J. A. Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life 61, 47-55 (2009).","DOI":"10.1002\/iub.142"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Bosma, M.; Kersten, S.; Hesselink, M. K.; Schrauwen, P. Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity. Prog. Lipid Res. 51, 36-49 (2012).","DOI":"10.1016\/j.plipres.2011.11.003"},{"key":"4","unstructured":"4) Bergman, B. C.; Perreault, L.; Hunerdosse, D. M.; Koehler, M. C.; Samek, A. M.; Eckel, R. H. Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J. Appl. Physiol. 108, 1134-1141 (2010)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Goodpaster, B. H.; He, J.; Watkins, S.; Kelley, D. E. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86, 5755-5761 (2001).","DOI":"10.1210\/jcem.86.12.8075"},{"key":"6","unstructured":"6) Lee, J. S.; Pinnamaneni, S. K.; Eo, S. J.; Cho, I. H.; Pyo, J. H.; Kim, C. K.; Sinclair, A. J.; Febbraio, M. A.; Watt, M. J.; Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J. Appl. Physiol. 100, 1467-1474 (2006)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Manco, M.; Mingrone, G.; Greco, A. V.; Capristo, E.; Gniuli, D.; De Gaetano, A.; Gasbarrini, G. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism 49, 220-224 (2000).","DOI":"10.1016\/S0026-0495(00)91377-5"},{"key":"8","unstructured":"8) Borkman, M.; Storlien, L. H.; Pan, D. A.; Jenkins, A. B.; Chisholm, D. J.; Campbell, L. V. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N. Engl. J. Med. 328, 238-244 (1993)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Pinnamaneni, S. K.; Southgate, R. J.; Febbraio, M. A.; Watt, M. J. Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia. 49, 3027-3037 (2006).","DOI":"10.1007\/s00125-006-0427-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Listenberger, L. L.; Han, X.; Lewis, S. E.; Cases, S.; Farese, R. V.; Jr Ory, D. S.; Schaffer, J. E. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA. 100, 3077-3082 (2003).","DOI":"10.1073\/pnas.0630588100"},{"key":"11","unstructured":"11) Dobrzyn, P.; Pyrkowska, A.; Jazurek, M.; Szymanski, K.; Langfort, J.; Dobrzyn, A. Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1. J. Appl. Physiol. 109, 1653-1661 (2010)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kahn, C. R.; Chen, L.; Cohen, S. E. Unraveling the mechanism of action of thiazolidinediones. J. Clin. Invest. 106, 1305-1307 (2000).","DOI":"10.1172\/JCI11705"},{"key":"13","unstructured":"13) Gorla-Bajszczak, A.; Siegrist-Kaiser, C.; Boss, O.; Burger, A. G.; Meier, C. A.; Expression of peroxisome proliferator-activated receptors in lean and obese Zucker rats. Eur. J. Endocrinol. 142, 71-78 (2000)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Oana, F.; Takeda, H.; Hayakawa, K.; Matsuzawa, A.; Akahane, S.; Isaji, M.; Akahane, M. Physiological difference between obese (fa\/fa) Zucker rats and lean Zucker rats concerning adiponectin. Metabolism 54, 995-1001 (2005).","DOI":"10.1016\/j.metabol.2005.02.016"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Lessard, S. J.; Lo Giudice, S. L.; Lau, W.; Reid, J. J.; Turner, N.; Febbraio, M. A.; Hawley, J. A.; Watt, M. J. Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle. Endocrinology 145, 5665-5670 (2004).","DOI":"10.1210\/en.2004-0659"},{"key":"16","unstructured":"16) Chabowski, A.; Zendzian-Piotrowska, M.; Nawrocki, A.; G&oacute;rski, J. Not only accumulation, but also saturation status of intramuscular lipids is significantly affected by PPAR\u03b3 activation. Acta. Physiol. 205, 145-158 (2012)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Juurlink, D. N.; Gomes, T.; Lipscombe, L. L; Austin, P. C; Hux, J. E.; Mamdani, M. M. Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study. BMJ 339, b2942 (2009).","DOI":"10.1136\/bmj.b2942"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Graham, D.; Ouellet-Hellstrom, R.; MaCurdy, T. E.; Ali, F.; Sholley, C.; Worrall, C.; Kelman, J. A. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. JAMA. 304, 411-418 (2010).","DOI":"10.1001\/jama.2010.920"},{"key":"19","unstructured":"19) Seethala, R.; Golla, R.; Ma, Z.; Zhang, H.; O\u2019Malley, K.; Lippy, J.; Cheng, L.; Mookhtiar, K.; Farrelly, D.; Zhang, L.; Hariharan, N.; Cheng, P. T. A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha\/gamma activator. Anal. Biochem. 363, 263-274 (2007)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Farese, R. V.; Yost, T. J.; Eckel, R. H. Tissue-specific regulation of lipoprotein lipase activity by insulin\/glucose in normal-weight humans. Metabolism 40, 214-216 (1991).","DOI":"10.1016\/0026-0495(91)90178-Y"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Pollare, T.; Vessby, B.; Lithell, H. Lipoprotein lipase activity in skeletal muscle is related to insulin sensitivity. Arterioscler. Thromb. 11, 1192-1203 (1991).","DOI":"10.1161\/01.ATV.11.5.1192"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Folch, J.; Lees, M.; Sloane Stanley, G. H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509 (1957).","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Shimomura, Y.; Tamura, T.; Suzuki, M. Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet. J. Nutr. 120, 1291-1296 (1990).","DOI":"10.1093\/jn\/120.11.1291"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Nilsson-Ehle, P.; Schotz, M. C. A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J. Lipid Res. 17, 536-541 (1976).","DOI":"10.1016\/S0022-2275(20)41752-3"},{"key":"25","unstructured":"25) Kubota, N.; Terauchi, Y.; Kubota, T.; Kumagai, H.; Itoh, S.; Satoh, H.; Yano, W.; Ogata, H.; Tokuyama, K.; Takamoto, I.; Mineyama, T.; Ishikawa, M.; Moroi, M.; Sugi, K.; Yamauchi, T.; Ueki, K.; Tobe, K.; Noda, T.; Nagai, R.; Kadowaki, T. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J. Biol. Chem. 281, 8748-8755 (2006)."},{"key":"26","unstructured":"26) Singh Ahuja, H.; Liu, S.; Crombie, D. L.; Boehm, M.; Leibowitz, M. D.; Heyman, R. A.; Depre, C.; Nagy, L.; Tontonoz, P.; Davies, P. J. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. Mol. Pharmacol. 59, 765-773 (2001)."},{"key":"27","unstructured":"27) Kuda, O.; Stankova, B.; Tvrzicka, E.; Hensler, M.; Jelenik, T.; Rossmeisl, M.; Flachs, P.; Kopecky, J. Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet. J. Physiol. Pharmacol. 60, 135-140 (2009)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Dobrzyn, A.; Ntambi, J. M. The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins Leukot. Essent. Fatty Acids 73, 35-41 (2005).","DOI":"10.1016\/j.plefa.2005.04.011"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Schenk, S.; Horowitz, J. F. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J. Clin. Invest. 117, 1690-1698 (2007).","DOI":"10.1172\/JCI30566"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Timmers, S.; Schrauwen, P.; de Vogel, J. Muscular diacylglycerol metabolism and insulin resistance. Physiol. Behav. 94, 242-251 (2008).","DOI":"10.1016\/j.physbeh.2007.12.002"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Gao, D.; Griffiths, H. R.; Bailey, C. J. Oleate protects against palmitate-induced insulin resistance in L6 myotubes. Br. J. Nutr. 102, 1557-1563 (2009).","DOI":"10.1017\/S0007114509990948"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Peng, G.; Li, L.; Liu, Y.; Pu, J.; Zhang, S.; Yu, J.; Zhao, J.; Liu, P. Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle. Endocrinology 152, 2206-2218 (2011).","DOI":"10.1210\/en.2010-1369"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Tamilarasan, K. P.; Temmel, H.; Das, S. K.; Al Zoughbi, W.; Schauer, S.; Vesely, P. W.; Hoefler, G. Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity. Cell Death Dis. 3, e354 (2012).","DOI":"10.1038\/cddis.2012.91"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Ferreira, L. D.; Pulawa, L. K.; Jensen, D. R.; Eckel, R. H. Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance. Diabetes 50, 1064-1068 (2001).","DOI":"10.2337\/diabetes.50.5.1064"},{"key":"35","unstructured":"35) Kageyama, H.; Hirano, T.; Okada, K.; Ebara, T.; Kageyama, A.; Murakami, T.; Shioda, S.; Adachi, M. Lipoprotein lipase mRNA in white adipose tissue but not in skeletal muscle is increased by pioglitazone through PPAR-gamma. Biochem. Biophys. Res. Commun. 305, 22-27 (2003)."},{"key":"36","unstructured":"36) Dobrzyn, A.; Dobrzyn, P.; Lee, S. H.; Miyazaki, M.; Cohen, P.; Asilmaz, E.; Hardie, D. G.; Friedman, J. M.; Ntambi, J. M. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 288, E599-E607 (2005)."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Hulver, M. W.; Berggren, J. R.; Carper, M. J.; Miyazaki, M.; Ntambi, J. M.; Hoffman, E. P.; Thyfault, J. P.; Stevens, R.; Dohm, G. L.; Houmard, J. A.; Muoio, D. M. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2, 251-261 (2005).","DOI":"10.1016\/j.cmet.2005.09.002"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Ntambi, J. M.; Miyazaki, M.; Stoehr, J. P.; Lan, H.; Kendziorski, C. M.; Yandell, B. S.; Song, Y.; Cohen, P.; Friedman, J. M.; Attie, A. D. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. USA. 99, 11482-11486 (2002).","DOI":"10.1073\/pnas.132384699"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Miyazaki, M.; Kim, Y. C.; Ntambi, J. M. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid. Res. 42, 1018-1024 (2001).","DOI":"10.1016\/S0022-2275(20)31589-3"},{"key":"40","unstructured":"40) Toyama, T.; Kudo, N.; Hibino, Y.; Mitsumoto, A.; Nishikawa, M.; Kawashima, Y. Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa\/fa rats. J. Pharmacol. Sci. 104, 137-145 (2007)."}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/62\/9\/62_745\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:26:57Z","timestamp":1646479617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/62\/9\/62_745\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.62.745","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}