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Phases and phase transitions of the sphingolipids. Biochim. Biophys. Acta 1255, 213-236 (1995).","DOI":"10.1016\/0005-2760(94)00202-A"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Chen, L.; Wang, J. J.; Song, H. T.; Zhang, G. G.; Qin, L. P. New cytotoxic cerebroside from Gynura divaricata. Chin. Chem. Lett. 20, 1091-1093 (2009).","DOI":"10.1016\/j.cclet.2009.04.021"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Guo, S.; Xue, C. H.; Xu, J.; Wang, Y. M.; Cong, P. X. Three glucocerebroside molecular species from the sea cucumber Apostichopus japonicus. Adv. Mat. Res. 524, 2334-2339 (2012).","DOI":"10.4028\/www.scientific.net\/AMR.524-527.2334"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ohashi, Y.; Tanaka, T.; Akashi, S.; Morimoto, S.; Kishimoto, Y.; Nagai,Y. Squid nerve sphingomyelin containing an unusual sphingoid base. J. Lipid Res. 41, 1118-1124 (2000).","DOI":"10.1016\/S0022-2275(20)32018-6"},{"key":"5","unstructured":"5) Sugawara, T.; Zaima, N.; Yamamoto, A.; Sakai, S.; Noguchi, R.; Hirata, T. Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells. Biosci. Biotechnol. Biochem. 12, 2906-2912 (2006)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Sperling, P.; Heinz, E. Plant sphingolipids: structural diversity, biosynthesis, first genes and functions. Biochim. Biophys. Acta 1632, 1-15 (2003).","DOI":"10.1016\/S1388-1981(03)00033-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Duan, R. D.; Nilsson, A. Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development. Prog. Lipid Res. 48, 62-72 (2009).","DOI":"10.1016\/j.plipres.2008.04.003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Karlsson, K. A. Sphingolipid long chain bases. 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Glucocerebroside ameliorates the metabolic syndrome in OB\/OB mice. J. Pharmacol. Exp. Ther. 319, 105-110 (2006).","DOI":"10.1124\/jpet.106.104950"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tang, J.; Meng, X.; Liu, H.; Zhao, J.; Zhou, L.; Qiu, M. Antimicrobial activity of sphingolipids isolated from the stems of cucumber (Cucumis sativus L.). Molecules 15, 9288-9297 (2010).","DOI":"10.3390\/molecules15129288"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Natori, T.; Morita, M.; Akimoto, K.; Koezuka, Y. Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus. Tetrahedron 50, 2771-2784 (1994).","DOI":"10.1016\/S0040-4020(01)86991-X"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sugawara, T.; Kinoshita, M.; Ohnishi, M.; Nagata, J.; Saito, M. Digestion of maize sphingolipids in rats and uptake of sphingadienine by Caco-2 cells. J. 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