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A colorimetric method for the determination of phenols (and phenol derivatives) in urine. J. Biol. Chem. 22, 305-308 (1915).","DOI":"10.1016\/S0021-9258(18)87648-7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Reeves, P.G.; Nielsen, F.H.; Fahey, G.C.Jr. AIN-93 purified diets for laboratory rodents: final report of the american institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent Diet. J. Nutr. 123, 1939-1951 (1993).","DOI":"10.1093\/jn\/123.11.1939"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Folch, J.; Ascoli, I.; Lees, M. Preparation of lipid extracts from brain tissue. J. Biol. Chem. 191, 833-841 (1951).","DOI":"10.1016\/S0021-9258(18)55987-1"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ide, T.; Okamatsu, H.; Sugano, M. Regulation by dietary fats of 3-Hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver. J. 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