{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:56:51Z","timestamp":1777370211354,"version":"3.51.4"},"reference-count":43,"publisher":"Japan Oil Chemists' Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2018]]},"DOI":"10.5650\/jos.ess18043","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T22:29:34Z","timestamp":1534199374000},"page":"1137-1147","source":"Crossref","is-referenced-by-count":11,"title":["Dietary &lt;i&gt;Sparassis crispa&lt;\/i&gt; Reduces Body Fat Mass and Hepatic Lipid Levels by Enhancing Energy Expenditure and Suppressing Lipogenesis in Rats"],"prefix":"10.5650","volume":"67","author":[{"given":"Ai","family":"Takeyama","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bungo","family":"Shirouchi","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubasa","family":"Haraguchi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Tamaya","sequence":"additional","affiliation":[{"name":"Industrial Technology Center of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Matsuura Plant of Chukoh Chemical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Nursing and Nutrition, University of Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Eckel, R.H.; Grundy, S.M.; Zimmet, P.Z. The metabolic syndrome. Lancet 365, 1415-1428 (2005).","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Nagao, K.; Wang, Y.M.; Inoue, N.; Han, S.Y.; Buang, Y.; Noda, T.; Kouda, N.; Okamatsu, H.; Yanagita, T. The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. Nutrition 19, 652-656 (2003).","DOI":"10.1016\/S0899-9007(03)00060-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Nagao, K.; Jinnouchi, T.; Kai, S.; Yanagita, T. Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats. Lipids Health Dis. 12, 8 (2013).","DOI":"10.1186\/1476-511X-12-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Nagao, K.; Jinnouchi, T.; Kai, S.; Yanagita, T. Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats. J. Nutr. Biochem. 43, 151-155 (2017).","DOI":"10.1016\/j.jnutbio.2017.02.009"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Kim, M.; Goto, T.; Yu, R.; Uchida, K.; Tominaga, M.; Kano, Y.; Takahashi, N.; Kawada, T. Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system. Sci. Rep. 5, 18013 (2015).","DOI":"10.1038\/srep18013"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Shirouchi, B.; Nagao, K.; Umegatani, M.; Shiraishi, A.; Morita, Y.; Kai, S.; Yanagita, T.; Ogawa, A.; Kadooka, Y.; Sato, M. Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces bodyweight gain in rats by stimulating energy expenditure. Br. J. Nutr. 116, 451-458 (2016).","DOI":"10.1017\/S0007114516002245"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Vincent, M.; Philippe, E.; Everard, A.; Kassis, N.; Rouch, C.; Denom, J.; Takeda, Y.; Uchiyama, S.; Delzenne, N.M.; Cani, P.D.; Migrenne, S.; Magnan, C. Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats. Obesity 21, 553-561 (2013).","DOI":"10.1002\/oby.20276"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Zaidman, B.Z.; Yassin, M.; Mahajna, J.; Wasser, SP. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl. Microbiol. Biotechnol. 67, 453-468 (2005).","DOI":"10.1007\/s00253-004-1787-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Wasser, S.P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl. Microbiol. Biotechnol. 60, 258-274 (2002).","DOI":"10.1007\/s00253-002-1076-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Guillam\u00f3n, E.; Garc\u00eda-Lafuente, A.; Lozano, M.; D\u2019Arrigo, M.; Rostagno, M.A.; Villares, A.; Mart\u00ednez, J.A. Edible mushrooms: role in the prevention of cardiovascular diseases. Fitoterapia 81, 715-723 (2010).","DOI":"10.1016\/j.fitote.2010.06.005"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Nagao, K.; Inoue, N.; Inafuku, M.; Shirouchi, B.; Morooka, T.; Nomura, S.; Nagamori, N.; Yanagita, T. Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db\/db mice. J. Nutr. Biochem. 21, 418-423 (2010).","DOI":"10.1016\/j.jnutbio.2009.01.021"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Inoue, N.; Inafuku, M.; Shirouchi, B.; Nagao, K.; Yanagita, T. Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob\/ob mice. Lipids Health Dis. 12, 18 (2013).","DOI":"10.1186\/1476-511X-12-18"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Fukushima, M.; Ohashi, T.; Fujiwara, Y.; Sonoyama, K.; Nakano, M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp. Biol. Med. (Maywood). 226, 758-765 (2001).","DOI":"10.1177\/153537020222600808"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Julie, A.F.; Rijin, X.; Shanggong, Y.; Matthew, F.; Leah, J.H.; Pippa, M.S.; Martin, J.J.R.; Nianbai, F.; Thomas, M.B.; Frank, A.S. Effect of Shiitake mushroom dose on colon tumorigenesis in azoxymethane-treated male Sprague-Dawley rats. Nutr. Res. 26, 138-145 (2006).","DOI":"10.1016\/j.nutres.2006.03.001"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kimura, T. Natural products and biological activity of the pharmacologically active cauliflower mushroom Sparassis crispa. Biomed. Res. Int. 2013, 982317 (2013).","DOI":"10.1155\/2013\/982317"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Folch, J.; Lees, M.; Sloane Stanley, G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509 (1957).","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Lo, S.; Russell, J.C.; Taylor, A.W. Determination of glycogen in small tissue samples. J. Appl. Physiol. 28, 234-236 (1970).","DOI":"10.1152\/jappl.1970.28.2.234"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; Randall, R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ochoa, S. Malic enzyme. Methods Enzymol. 1, 739-753 (1955).","DOI":"10.1016\/0076-6879(55)01129-4"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kelley, D.S.; Kletzien, R.F. Ethanol modulation of the hormonal and nutritional regulation of glucose 6-phosphate dehydrogenase activity in primary cultures of rat hepatocytes. Biochem. J. 217, 543-549 (1984).","DOI":"10.1042\/bj2170543"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kelley, D.S.; Nelson, G.J.; Hunt, J.E. Effect of prior nutritional status on the activity of lipogenic enzymes in primary monolayer cultures of rat hepatocytes. Biochem. J. 235, 87-90 (1986).","DOI":"10.1042\/bj2350087"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Walton, P.A.; Possmayer, F. Mg2-dependent phosphatidate phosphohydrolase of rat lung: development of an assay employing a defined chemical substrate which reflects the phosphohydrolase activity measured using membrane-bound substrate. Anal. Biochem. 151, 479-486 (1985).","DOI":"10.1016\/0003-2697(85)90208-8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Sato, M.; Ueda, T.; Nagata, K.; Shiratake, S.; Tomoyori, H.; Kawakami, M.; Ozaki, Y.; Okubo, H.; Shirouchi, B.; Imaizumi, K. Dietary kakrol (Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats. Exp. Biol. Med. (Maywood) 236, 1139-1146 (2011).","DOI":"10.1258\/ebm.2011.011037"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Jeejeebhoy, K.N.; Ahmad, S.; Kozak, G. Determination of fecal fats containing both medium and long chain triglycerides and fatty acids. Clin. Biochem. 3, 157-163 (1970).","DOI":"10.1016\/S0009-9120(70)80021-2"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Mizutani, T.; Inatomi, S.; Inazu, A.; Kawahara, E. Hypolipidemic effect of Pleurotus eryngii extract in fat-loaded mice. J. Nutr. Sci. Vitaminol. (Tokyo) 56, 48-53 (2010).","DOI":"10.3177\/jnsv.56.48"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Hiraki, E.; Furuta, S.; Kuwahara, R.; Takemoto, N.; Nagata, T.; Akasaka, T.; Shirouchi, B.; Sato, M.; Ohnuki, K.; Shimizu, K. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J. Nat. Med. 71, 482-491 (2017).","DOI":"10.1007\/s11418-017-1075-8"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ley, R.E.; B\u00e4ckhed, F.; Turnbaugh, P.; Lozupone, C.A.; Knight, R.D.; Gordon, J.I. Obesity alters gut microbial ecology. Proc. Natl. Acad. Sci. U S A 102, 11070-11075 (2005).","DOI":"10.1073\/pnas.0504978102"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Turnbaugh, P.J.; Ley, R.E.; Mahowald, M.A.; Magrini, V.; Mardis, E.R.; Gordon, J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006).","DOI":"10.1038\/nature05414"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Hara, T.; Kashihara, D.; Ichimura, A.; Kimura, I.; Tsujimoto, G.; Hirasawa, A. Role of free fatty acid receptors in the regulation of energy metabolism. Biochim. Biophys. Acta 1841, 1292-1300 (2014).","DOI":"10.1016\/j.bbalip.2014.06.002"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kimura, I.; Inoue, D.; Maeda, T.; Hara, T.; Ichimura, A.; Miyauchi, S.; Kobayashi, M.; Hirasawa, A.; Tsujimoto, G. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc. Natl. Acad. Sci. U S A 108, 8030-8035 (2011).","DOI":"10.1073\/pnas.1016088108"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Lu, H.; Gui, Y.; Guo, T.; Wang, Q.; Liu, X. Effect of the particle size of cellulose from sweet potato residues on lipid metabolism and cecal conditions in ovariectomized rats. Food Funct. 6, 1185-1193 (2015).","DOI":"10.1039\/C4FO00799A"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Kawakami, S.; Araki, T.; Ohba, K.; Sasaki, K.; Kamada, T.; Shimada, K.; Han, K.H.; Fukushima, M. Comparison of the effect of two types of whole mushroom (Agaricus bisporus) powders on intestinal fermentation in rats. Biosci. Biotechnol. Biochem. 80, 2001-2006 (2016).","DOI":"10.1080\/09168451.2016.1196573"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Yamamoto, K.; Kimura, T. Dietary Sparassis crispa (Hanabiratake) ameliorates plasma levels of adiponectin and glucose in type 2 diabetic mice. J. Health Sci. 56, 541-546 (2010).","DOI":"10.1248\/jhs.56.541"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Bellahcene, M.; O\u2019Dowd, J.F.; Wargent, E.T.; Zaibi, M.S.; Hislop, D.C.; Ngala, R.A.; Smith, D.M.; Cawthorne, M.A.; Stocker, C.J.; Arch, J.R. Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. Br. J. Nutr. 109, 1755-1764 (2013).","DOI":"10.1017\/S0007114512003923"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Gao, Z.; Yin, J.; Zhang, J.; Ward, R.E.; Martin, R.J.; Lefevre, M.; Cefalu, W.T.; Ye, J. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58, 1509-1517 (2009).","DOI":"10.2337\/db08-1637"},{"key":"36","unstructured":"36) Sima, P.; Vannucci, L.; Vetvicka, V. \u03b2-Glucans and cholesterol (Review). Int. J. Mol. Med. 41, 1799-1808 (2018)."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Bang, S.; Chae, H.S.; Lee, C.; Choi, H.G.; Ryu, J.; Li, W.; Lee, H.; Jeong, G.S.; Chin, Y.W.; Shim, S.H. New aromatic compounds from the fruiting body of Sparassis crispa (Wulf.) and their inhibitory activities on proprotein convertase subtilisin\/kexin type 9 mRNA expression. J. Agric. Food Chem. 65, 6152-6157 (2017).","DOI":"10.1021\/acs.jafc.7b02657"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Seo, C.; Choi, Y.H.; Ahn, J.S.; Yim, J.H.; Lee, H.K.; Oh, H. PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica. J. Enzyme Inhib. Med. Chem. 24, 1133-1137 (2009).","DOI":"10.1080\/14756360802667811"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Ogawa, H.; Okada, Y.; Kamisako, T.; Baba, K. Beneficial effect of xanthoangelol, a chalcone compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 34, 238-243 (2007).","DOI":"10.1111\/j.1440-1681.2007.04578.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Zhang, T.; Sawada, K.; Yamamoto, N.; Ashida, H. 4-Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways. Mol. Nutr. Food Res. 57, 1729-1740 (2013).","DOI":"10.1002\/mnfr.201300020"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Li, Y.; Goto, T.; Ikutani, R.; Lin, S.; Takahashi, N.; Takahashi, H.; Jheng, H.F.; Yu, R.; Taniguchi, M.; Baba, K.; Murakami, S.; Kawada, T. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring) 24, 2351-2360 (2016).","DOI":"10.1002\/oby.21611"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Ohta, M.; Fujinami, A.; Kobayashi, N.; Amano, A.; Ishigami, A.; Tokuda, H.; Suzuki, N.; Ito, F.; Mori, T.; Sawada, M.; Iwasa, K.; Kitawaki, J.; Ohnishi, K.; Tsujikawa, M.; Obayashi, H. Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1\/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes. Nutr. Res. 35, 618-625 (2015).","DOI":"10.1016\/j.nutres.2015.05.010"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Kawabata, K.; Sawada, K.; Ikeda, K.; Fukuda, I.; Kawasaki, K.; Yamamoto, N.; Ashida, H. Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation. Mol. Nutr. Food Res. 55, 467-475 (2011).","DOI":"10.1002\/mnfr.201000267"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/67\/9\/67_ess18043\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:02:42Z","timestamp":1661749362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/67\/9\/67_ess18043\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess18043","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}