{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:55:07Z","timestamp":1784051707036,"version":"3.55.0"},"reference-count":31,"publisher":"Japan Oil Chemists' Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2018]]},"DOI":"10.5650\/jos.ess18115","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T22:32:36Z","timestamp":1539210756000},"page":"1339-1345","source":"Crossref","is-referenced-by-count":19,"title":["Nephroprotective Effect of Essential Oils from Ginger (<i>Zingiber officinale<\/i>) and Turmeric (<i>Curcuma longa<\/i>) Rhizomes against Cadmium-induced Nephrotoxicity in Rats"],"prefix":"10.5650","volume":"67","author":[{"given":"Ayodele Jacob","family":"Akinyemi","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry Unit, Afe Babalola University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwabamise Lekan","family":"Faboya","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Chemistry Unit, Afe Babalola University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awonegan Ayodeji","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Science Technology, The Federal Polytechnic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Olayide","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry Unit, Afe Babalola University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeyemi Ayodeji","family":"Faboya","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Ekiti State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus Ademola","family":"Oluwasola","sequence":"additional","affiliation":[{"name":"Department of Animal Production and Health Sciences, Ekiti State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3621","reference":[{"key":"1","unstructured":"1) Jarup, L.; Berglund, M.; Elinder, C.G.; Nordberg, G.; Vahter, M. Health effects of cadmium exposure: A review of the literature and a risk estimate. Scand. J. Work Environ. Health 24, 1-51 (1998)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Min, K.S.; Kim, H.; Fujii, M.; Tetsuchikawahara, N.; Onosaka, S. Glucocorticoids suppress the inflammation-mediated tolerance to acute toxicity of cadmium in mice. Toxicol. Appl. Pharmacol. 178, 1-7 (2002).","DOI":"10.1006\/taap.2001.9323"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Erboga, M.; Kanter, M.; Aktas, C.; Sener, U.; Erboga, Z.F.; Donmez, Y.B.; Gurel, A. Thymoquinone ameliorates cadmium-induced nephrotoxicity, apoptosis, and oxidative stress in rats is based on its anti-apoptotic and anti-oxidant properties. Biol. Trace Elem. Res. 170, 165-172 (2016).","DOI":"10.1007\/s12011-015-0453-x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"5) Thijssen, S.; Cuypers, A.; Maringwa, J.; Smeets, K.; Horemans, N.; Lambrichts, I.; van Kerkhove, E. Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology 236, 29-41 (2007).","DOI":"10.1016\/j.tox.2007.03.022"},{"key":"5","doi-asserted-by":"crossref","unstructured":"6) Go, Y.M.; Roede, J.R.; Orr, M.; Liang, Y.; Jones, D.P. Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of Cd toxicity. Toxicol. Sci. 139, 59-73 (2014).","DOI":"10.1093\/toxsci\/kfu018"},{"key":"6","doi-asserted-by":"crossref","unstructured":"7) Geiger, L.J. The essential oil of ginger, Zingiber officinale, and anaesthesia. Int. J. Aromather. 15, 7-14 (2005).","DOI":"10.1016\/j.ijat.2004.12.002"},{"key":"7","doi-asserted-by":"crossref","unstructured":"8) Masuda, Y.; Kikuzaki, H.; Hisamoto, M.; Nakatani, N. Antioxidant properties of gingerol related compounds from ginger. Biofactors 21, 293-296 (2004).","DOI":"10.1002\/biof.552210157"},{"key":"8","doi-asserted-by":"crossref","unstructured":"9) Zhou, H.L.; Deng, Y.M.; Xie, Q.M. The modulatory effects of the volatile oil of ginger on the cellular immune response in vitro and in vivo in mice. J. Ethnopharmacol. 105, 301-305 (2006).","DOI":"10.1016\/j.jep.2005.10.022"},{"key":"9","unstructured":"10) Biapa Nya Prosper, C.; Kuiate Jules, R.; Wankeu Modeste, Ntiokam D. Acute and subacute toxicity studies of Zinginber officinalis Roscoe essential oil on mice (Swiss) and rats (Wistar). Afr. J. Pharmaceutical Sci. Pharmacy 1, 39-49 (2010)."},{"key":"10","unstructured":"11) Sawamura, M. Aroma and functional properties of Japanese yuzu (Citrus junos Tanaka) essential oil. Aroma Res. 1, 14-19 (2000)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"12) Jayaprakasha, G.K.; Jagan Rao, L.; Sakariah, K.K. Chemistry and biological activities of C. longa. Trends Food Sci. Tech. 16, 533-548 (2005).","DOI":"10.1016\/j.tifs.2005.08.006"},{"key":"12","doi-asserted-by":"crossref","unstructured":"13) Hastak, K.; Lubri, N.; Jakhi, S.D.; More, C.; John, A.; Ghaisas, S.D. Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Lett. 116, 265-269 (1997).","DOI":"10.1016\/S0304-3835(97)00205-X"},{"key":"13","doi-asserted-by":"crossref","unstructured":"14) Norajit, K.; Laohakunjit, N.; Kerdchoechuen, O. Antibacterial effect of five Zingiberaceae essential oils. Molecules 12, 2047-2060 (2007).","DOI":"10.3390\/12082047"},{"key":"14","doi-asserted-by":"crossref","unstructured":"15) Liju, V.B.; Jeena, K.; Kuttanet, R. Antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J. Pharmacol. 43, 526-531 (2011).","DOI":"10.4103\/0253-7613.84961"},{"key":"15","doi-asserted-by":"crossref","unstructured":"16) Aktoz, T.; Kanter, M.; Uz, Y.H.; Aktas, C.; Erboa, M.; Atakan, I.H. Protective effect of quercetin against renal toxicity induced by cadmium in rats. Balkan Med. J. 29, 56-61 (2012).","DOI":"10.5152\/balkanmedj.2011.014"},{"key":"16","unstructured":"17) Guisti, G.; Galanti, B. Colorimetric method. in Methods of Enzymatic Analysis (Bergmeyer, H.U. ed.). Verlag Chemie, Weinheim, pp. 315-323 (1984)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"18) Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 (1976).","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"18","doi-asserted-by":"crossref","unstructured":"19) Prozialeck, W.C.; Edwards, J.R. Cell adhesion molecules in chemically induced renal injury. Pharmacol. Ther. 114, 74-93 (2007).","DOI":"10.1016\/j.pharmthera.2007.01.001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"20) Boroushaki, M.T.; Mollazadeh, H,; Rajabian, A.; Dolati, K.; Hoseini, A.; Paseban, M.; Farzadnia, M. Protective effect of pomegranate seed oil against mercuric chloride-induced nephrotoxicity in rat. Ren. Fail. 36, 1581-1586 (2014).","DOI":"10.3109\/0886022X.2014.949770"},{"key":"20","unstructured":"21) Obianime, A.W.; Roberts, II. Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats. Niger. J. Physiol. Sci. 24, 177-185 (2009)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"22) Renugadevi, J.; Milton Prabu, S. Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology 256, 128-134 (2009).","DOI":"10.1016\/j.tox.2008.11.012"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23) Jung, H.Y.; Seo, D.W.; Hong, C.O.; Kim, J.Y.; Yang, S.Y.; Lee, K.W. Nephroprotection of plantamajoside in rats treated with cadmium. Environ. Toxicol. Pharmacol. 39, 125-136 (2015).","DOI":"10.1016\/j.etap.2014.11.012"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24) Ajith, T.A.; Aswathy, M.S.; Hema, U. Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food Chem. Toxicol. 46, 3178-3181 (2008).","DOI":"10.1016\/j.fct.2008.07.004"},{"key":"24","doi-asserted-by":"crossref","unstructured":"25) Jeena, K.; Liju, V.B.; Kuttan, R. A preliminary 13-week oral toxicity study of ginger oil in male and female Wistar rats. Int. J. Toxicol. 30, 662-670 (2011).","DOI":"10.1177\/1091581811419023"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26) Ademiluyi, A.O.; Oboh, G.; Ogunsuyi, O.B.; Akinyemi, A.J. Attenuation of gentamycin-induced nephrotoxicity in rats by dietary inclusion of ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes. Nutr. Health 21, 209-218 (2012).","DOI":"10.1177\/0260106013506668"},{"key":"26","unstructured":"27) Jurenka, J. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev. 14, 141-153 (2009)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"28) Bagad, A.S.; Joseph, J.A.; Bhaskaran, N.; Agarwal, A. Comparative evaluation of anti-inflammatory activity of curcuminoids, turmerones, and aqueous extract of Curcuma longa. Adv. Pharmacol. Sci. 2013, 805756 (2013).","DOI":"10.1155\/2013\/805756"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29) Hart, P.H.; Brand, C.; Carson, C.F.; Riley, T.V.; Prager, R.H.; Finlay-Jones, J.J. Terpinen-4-ol, the main component of the essential oil of Malaleuca altemifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflamm. Res. 49, 619-626 (2000).","DOI":"10.1007\/s000110050639"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30) Burnstock, G. Historical review: ATP as a neurotransmitter. Trends Pharmacol. Sci. 27, 166-176 (2006).","DOI":"10.1016\/j.tips.2006.01.005"},{"key":"30","doi-asserted-by":"crossref","unstructured":"31) Rial, D.; Lara, D.R.; Cunha, R.A. The adenosine neuromodulation system in schizophrenia. Int. Rev. Neurobiol. 119, 395-449 (2014).","DOI":"10.1016\/B978-0-12-801022-8.00016-7"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32) Antonioli, L.; Colucci, R.; La Motta, C.; Tuccori, M.; Awwad, O.; Da Settimo, F.; Blandizzi, C.; Fornai, M. Adenosine deaminase in the modulation of immune system and its potential as a novel target for treatment of inflammatory disorders. Curr. Drug Targets 13, 842-862 (2012).","DOI":"10.2174\/138945012800564095"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/67\/10\/67_ess18115\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T05:11:13Z","timestamp":1539407473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/67\/10\/67_ess18115\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess18115","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}