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Behav. Immun. 85, 35-45 (2020).","DOI":"10.1016\/j.bbi.2019.05.033"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Timoszuk, M.; Bielawska, K.; Skrzydlewska, E. Evening primrose (Oenothera biennis) biological activity dependent on chemical composition. Antioxidants 7 (8), 108 (2018).","DOI":"10.3390\/antiox7080108"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Al-Okbi, S.Y.; El-qousy, S.M.; El-Ghlban, S.; Moawad, H.F. Role of borage seed oil and fish oil with or without turmeric and alpha- tocopherol in prevention of cardiovascular disease and fatty liver in rats. J. Oleo Sci. 67, 1551-1562 (2018).","DOI":"10.5650\/jos.ess18064"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Indarti, E.; Majid, M.I.A.; Hashim, R.; Chong, A. Direct FAME synthesis for rapid total lipid analysis from fish oil and cod liver oil. J. Food Compost. Anal. 18, 161-170 (2005).","DOI":"10.1016\/j.jfca.2003.12.007"},{"key":"15","unstructured":"15) Al-Okbi, S.Y.; Abdel-Razek, A.G.; Mohammed, S.E.; Ottai, M.E. Roselle seed as a potential new source of healthy edible oil. J. Biol. Sci. 17, 267-277 (2017)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Al-Okbi, S.Y.; Mohamed, D.A.; Kandil, E.; Ahmed, E.K.; Mohammed, S.E. Functional ingredients and cardiovascular protective effect of pumpkin seed oils. Grasas y Aceites 65 (1), e007 (2014).","DOI":"10.3989\/gya.062813"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matsumoto, T.; Sato, A.; Suenaga, H.; Kobayashi, T.; Kamata, K. Modulations of shear stress-induced contractile responses and agonist-induced vasodilation in hypercholesterolemic rats. Atherosclerosis 175, 31-38 (2004).","DOI":"10.1016\/j.atherosclerosis.2004.02.017"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Westergren A. Studies of the suspension stability of the blood in pulmonary tuberculosis. Acta Medica Scand. 54, 247-282 (1921).","DOI":"10.1111\/j.0954-6820.1921.tb15179.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Burstein, M.; Scholnick, H.R.; Morfin, R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11, 583-595 (1970).","DOI":"10.1016\/S0022-2275(20)42943-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Megraw, R.; Dunn, D.; Biggs, H. Manual and continuous flow colorimetry of triacylglycerols by a fully enzymatic method. Clin. Chem. 25, 273-278 (1979).","DOI":"10.1093\/clinchem\/25.2.273"},{"key":"21","unstructured":"21) Richmond, W. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem. 19, 1350-1356 (1973)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Friedewald, W.T.; Levy, R.I.; Fredrickson, D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502 (1972).","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"23","unstructured":"24) Farrell, E.C. Magnesium. in Clinical Chemistry (Kaplan, L.A. et al. eds.), The CV Mosby Co., St Louis, Toronto, Princeton, pp. 1065-1070 (1984)."},{"key":"24","unstructured":"25) Montgomery, H.A.C.; Dymock, J.F. The determination of nitrite in water. Analyst 86, 414-416 (1961)."},{"key":"25","doi-asserted-by":"crossref","unstructured":"26) Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin. Chim. Acta 90, 37-43 (1978).","DOI":"10.1016\/0009-8981(78)90081-5"},{"key":"26","unstructured":"27) Beutler, E.; Duron, O.; Kelly, M.B. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61, 882-888 (1963)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"28) Aebi, H. Catalase in vitro. Methods Enzymol. 105, 121-126 (1984).","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29) Sanderson, T.; Wild, G.; Cull, A.M.; Marston, J.; Zardin, G. Immunohistochemical and immunofluorescent techniques. in Bancroft\u2019s Theory and Practice of Histological Techniques (Suvarna, S.K.; Layton, C.; Bancroft, J.D. eds.) Vol. 8, Elsevier, pp. 337-394 (2019).","DOI":"10.1016\/B978-0-7020-6864-5.00019-0"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30) Bancroft, J.D.; Layton C. The hematoxylins and eosin. in Bancroft\u2019s Theory and Practice of Histological Techniques (Suvarna, S.K.; Layton, C.; Bancroft, J.D. eds.) Vol. 8, Elsevier, pp. 126-138 (2019).","DOI":"10.1016\/B978-0-7020-6864-5.00010-4"},{"key":"30","doi-asserted-by":"crossref","unstructured":"31) Prema, A.; Justin Thenmozhi, A.; Manivasagam, T.; Mohamed Essa, M.; Guillemin, G.J. Fenugreek seed powder attenuated aluminum chloride induced tau pathology, oxidative Stress, and inflammation in a rat model of Alzheimer\u2019s disease. J. Alzheimers Dis. 60 (S1), S209-S220 (2017).","DOI":"10.3233\/JAD-161103"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32) Mushtaq, G.; Greig, N.H.; Khan, J.A.; Kamal, M.A. Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer\u2019s disease and type 2 diabetes mellitus. CNS Neurol. Disord. Drug Targets 13, 1432-1439 (2014).","DOI":"10.2174\/1871527313666141023141545"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33) Slutsky, I.; Abumaria, N.; Wu, L.J.; Huang, C.; Zhang, L.; Li, B.; Zhao, X.; Govindarajan, A.; Zhao, M.G.; Zhuo, M.; Tonegawa, S.; Liu, G. Enhancement of learning and memory by elevating brain magnesium. Neuron 65, 165-177 (2010).","DOI":"10.1016\/j.neuron.2009.12.026"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34) Chui, D.; Chen, Z.; Yu, J.; Zhang, H.; Wang, W.; Song, Y.; Yang, H.; Liu, Y. Magnesuim in Alzheimer\u2019s disease. in Magnesuim in the Central Nervous System (Vink, R.; Nechifor, M. eds.) Adelaide, University of Adelaide Press, pp. 239-250 (2011).","DOI":"10.1017\/UPO9780987073051.019"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35) Kandimalla, R.; Vallamkondu, J.; Corgiat, E.B.; Gill, K.D. Understanding aspects of aluminum exposure in Alzheimer\u2019s disease development. Brain Pathol. 26, 139-154 (2016).","DOI":"10.1111\/bpa.12333"},{"key":"35","unstructured":"36) Castorina, A.; Tiralongo, A.; Giunta, S.; Luisa Carnazza, M.; Scapagnini, G. Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of b-amyloid toxicity. Cell Biol. Toxicol. 26, 367-377 (2010)."},{"key":"36","unstructured":"37) Olajide, O.J.; Yawson, E.O.; Gbadamosi, I.T.; Arogundade, T.T.; Lambe, E.; Obasi, K.; Lawal, I.T.; Ibrahim, A.; Ogunrinola, K.Y. Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer\u2019s disease. Environ. Toxicol. Pharmacol. 50, 200-211 (2017)."},{"key":"37","unstructured":"38) Montserrat-de la Paz, S.; Fernandez-Arche, M.A.; Angel-Martin, M.; Garcia-Gimenez, M.D. Phytochemical characterization of potential nutraceutical ingredients from evening primrose oil (Oenothera biennis L.). Phytochem. Lett. 8, 158-162 (2014)."},{"key":"38","unstructured":"39) Barrett, M. The handbook of clinically tested herbal remedies. The Haworth Herbal Press, Birmingham (NY) (2004)."},{"key":"39","doi-asserted-by":"crossref","unstructured":"40) Chilton, F.H.; Rudel, L.L.; Parks J.S.; Arm, J.P.; Seeds, M.C. Mechanisms by which botanical lipids affect inflammatory disorders. Am. J. Clin. Nutr. 87, 498S-503S (2008).","DOI":"10.1093\/ajcn\/87.2.498S"},{"key":"40","doi-asserted-by":"crossref","unstructured":"41) Ide, T.; Origuchi, I. Physiological effects of an oil rich in \u03b3-linolenic acid on hepatic fatty acid oxidation and serum lipid levels in genetically hyperlipidemic mice. J. Clin. Biochem. Nutr. 64, 148-157 (2019).","DOI":"10.3164\/jcbn.18-64"},{"key":"41","unstructured":"42) Gu, Y.; Nieves, J.W.; Stern, Y.; Luchsinger, J.A.; Scarmeas, N. Food combination and Alzheimer disease risk: A protective diet. Arch. Neurol. 67, 699-706 (2010)."},{"key":"42","doi-asserted-by":"crossref","unstructured":"43) Lim, G.P.; Calon, F.; Morihara, T.; Yang, F.; Teter, B.; Ubeda, O.; Salem, N.Jr.; Frautschy, S.A.; Cole, G.M. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci. 25, 3032-3040 (2005).","DOI":"10.1523\/JNEUROSCI.4225-04.2005"},{"key":"43","unstructured":"44) Vedin, I.; Cederholm, T.; Freund Levi, Y.; Basun, H.; Garlind, A.; Faxen Irving, G.; Jonhagen, M.E.; Vessby, B.; Wahlund, L.O.; Palmblad, J. Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. Am. J. Clin. Nutr. 87, 1616-1622 (2008)."},{"key":"44","unstructured":"45) Freund-Levi, Y.; Eriksdotter-Jonhagen, M.; Cederholm, T.; Basun, H.; FaxenIrving, G.; Garlind, A.; Vedin, I.; Vessby, B.; Wahlund, L.O.; Palmblad, J. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: Omeg AD study: a randomized double-blind trial. Arch. Neurol. 63, 1402-1408 (2006)."},{"key":"45","doi-asserted-by":"crossref","unstructured":"46) Quinn, J.F.; Raman, R.; Thomas, R.G.; Yurko-Mauro, K.; Nelson, E.B.; Van Dyck, C.; Galvin, J.E.; Emond, J.; Jack, C.R.Jr.; Weiner, M. et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 304, 1903-1911 (2010).","DOI":"10.1001\/jama.2010.1510"},{"key":"46","unstructured":"47) Vela, S.; Sainz, N.; Moreno-Aliaga, M.J.; Solas, M.; Ramirez, M.J. DHA selectively protects SAMP-8-associated cognitive deficits through inhibition of JNK. Mol. Neurobiol. 56, 1618-1627 (2019)."},{"key":"47","doi-asserted-by":"crossref","unstructured":"48) Luoa, C.; Rena, H.; Yaoc, X.; Shia, Z.; Liang, F.; Kangd, J.X.; Wan, J.; Pei, Z.; Su, K.; Sua, H. Enriched brain omega-3 polyunsaturated fatty acids confer neuroprotection against microinfarction. EBioMedicine 32, 50-61 (2018).","DOI":"10.1016\/j.ebiom.2018.05.028"},{"key":"48","doi-asserted-by":"crossref","unstructured":"49) Wang, L.; Fan, H.; He, J.; Wang, L.; Tian, Z.; Wang, C. Protective effects of omega-3 fatty acids against Alzheimer\u2019s disease in rat brain endothelial cells. 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