{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:59:57Z","timestamp":1771073997447,"version":"3.50.1"},"reference-count":40,"publisher":"Japan Oil Chemists' Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2021]]},"DOI":"10.5650\/jos.ess20255","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T22:06:31Z","timestamp":1618178791000},"page":"685-696","source":"Crossref","is-referenced-by-count":14,"title":["<i>Coix lacryma-jobi<\/i> Seed Oil Reduces Fat Accumulation in Nonalcoholic Fatty Liver Disease by Inhibiting the Activation of the p-AMPK\/SePP1\/apoER2 Pathway"],"prefix":"10.5650","volume":"70","author":[{"given":"Liangzhen","family":"Gu","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Provincial Chinese Medicine Classical Prescription Demonstration Engineering Technology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfang","family":"Kan","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Provincial Chinese Medicine Classical Prescription Demonstration Engineering Technology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajian","family":"Lv","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Hao","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Tian","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShiJun","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Provincial Chinese Medicine Classical Prescription Demonstration Engineering Technology Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Han","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine"},{"name":"Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Feng, W.H.; Bi, Y.; Li, P.; Yin, T.T.; Gao, C.X.; Shen, S.M.; Gao, L.J.; Yang, D.H.; Zhu, D.L. Effects of liraglutide; Metformin and gliclazide on body composition in patients with both type 2 diabetes and non-alcoholic fatty liver disease: A randomized trial. J. Diabetes Investig. 10, 399-407 (2019).","DOI":"10.1111\/jdi.12888"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Liu, K.; McCaughan, G.W. Epidemiology and etiologic associations of non-alcoholic fatty liver disease and associated HCC. Adv. Exp. Med. Biol. 1061, 3-18 (2018).","DOI":"10.1007\/978-981-10-8684-7_2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Miao, C.; Xie, Z.; Chang, J. Critical roles of microRNAs in the pathogenesis of fatty liver: New advances, challenges, and potential directions. Biochem. Genet. 56, 423-449 (2018).","DOI":"10.1007\/s10528-018-9870-9"},{"key":"4","unstructured":"4) Day, C.P.; James, O.F. Steatohepatitis: a tale of two \u201chits\u201d? Gastroenterology 114, 842-845 (1998)."},{"key":"5","unstructured":"5) Wu, Y.; Li, Y.; Tong, X.; Lu, F.; Mao, W.; Fu, L.; Deng, L.; Liu, X.; Li, C.; Zhang, L.; Liu, X. The effect of coix seed on the nutritional status of peritoneal dialysis patients: A pilot study. Complement. Ther. Med. 22, 40-48 (2014)."},{"key":"6","unstructured":"6) Cui, Y.; Rong, R.; Yang, Y.; Gong, L.L. Optimization of ultrasound-assisted acid extraction of polydaccharide from Coix seed. Chin. Arch. Trad. Chin. Med. 33, 2163-2146 (2015)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Zhang, X.W.; Liu, L.; Zhang, X.Z.; Bo, P. Kanglaite inhibits the expression of drug resistance genes through suppressing PVT1 in cisplatin-resistant gastric cancer cells. Exp. Ther. Med. 14, 1789-1794 (2017).","DOI":"10.3892\/etm.2017.4650"},{"key":"8","unstructured":"8) Han, X.; Ji, X.; Zhao, H.; Zhang, Y.; Liu, G.; Wang, Y.; Zhao, W.; Wang, S. Mechanisms of coix seed compositions in the treatment of spleen deficiency and wet dampness zheng. Afr. J. Tradit. Complement. Altern. Med. 14, 239-246 (2017)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Bi, M.; Zhang, H.; Yuan, L.; Zhao, L.; Liu, R. Molecular mechanisms of lead-induced changes of selenium status in mice livers through interacting with selenoprotein P. Ecotoxicol. Environ. Saf. 175, 282-288 (2019).","DOI":"10.1016\/j.ecoenv.2019.03.059"},{"key":"10","unstructured":"10) Mita, Y.; Nakayama, K.; Inari, S.; Nishito, Y.; Yoshioka, Y.; Sakai, N.; Sotani, K.; Nagamura, T.; Kuzuhara, Y.; Inagaki, K.; Iwasaki, M.; Misu, H.; Ikegawa, M.; Takamura, T.; Noguchi, N.; Saito, Y. Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Nat. Commun. 8, 1-17 (2017)."},{"key":"11","unstructured":"11) Lee, J.; Hong, S.W.; Park, S.E.; Rhee, E.J.; Park, C.Y.; Oh, K.W.; Park, S.W.; Lee, W.Y. Exendin-4 inhibits the expression of SEPP1 and fetuin-A via improvement of palmitic acid-induced endoplasmic reticulum stress by AMPK. Endocrinol. Metab. (Seoul). 30, 177-184 (2015)."},{"key":"12","unstructured":"12) Hayes, C.N.; Zhang, P.; Chayama, K. The role of lipids in hepatocellular carcinoma. Hepatocellular carcinoma. Chapter 5 (2019)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Satapathy, S.K.; Jiang, Y.; Agbim, U.; Wu, C.; Bernstein, D.E.; Teperman, L.W.; Kedia, S.K.; Aithal, G.P.; Bhamidimarri, K.R.; Duseja, A.; Maiwall, R.; Maliakkal, B.; Jalal, P.; Patel, K.; Puri, P.; Ravinuthala, R.; Wong, V.W.; Abdelmalek, M.F.; Ahmed, A.; Thuluvath, P.J.; Singal, A.K. Global NAFLD consortium. Posttransplant outcome of lean compared with obese nonalcoholic steatohepatitis in the United States: The obesity paradox. Liver Transpl. 26, 68-79 (2020).","DOI":"10.1002\/lt.25672"},{"key":"14","unstructured":"14) Garc\u00eda-Jaramillo, M.; Lytle, K.A.; Spooner, M.H.; Jump, D.B. A lipidomic analysis of docosahexaenoic acid (22:6, \u03c93) mediated attenuation of Western diet induced nonalcoholic steatohepatitis in male Ldlr -\/- mice. Metabolites 9, 252 (2019)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Divella, R.; Daniele, A.; DE Luca, R.; Mazzocca, A.; Ruggieri, E.; Savino, E.; Casamassima, P.; Simone, M.; Sabba, C.; Paradiso, A. Synergism of adipocytokine profile and ADIPOQ\/TNF-\u03b1 polymorphisms in NAFLD-associated MetS predict colorectal liver metastases outgrowth. Cancer Genomics Proteomics. 16, 519-530 (2019).","DOI":"10.21873\/cgp.20154"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Liu, T.; Luo, X.; Li, Z.H.; Wu, J.C.; Luo, S.Z.; Xu, M.Y. Zinc-\u03b12-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-\u03b1. World J. Gastroenterol. 25, 5451-5468 (2019).","DOI":"10.3748\/wjg.v25.i36.5451"},{"key":"17","unstructured":"17) Liu, Y.Z.; Peng, W.; Chen, J.K.; Su, W.J.; Yan, W.J.; Wang, Y.X.; Jiang, C.L. FoxO1 is a critical regulator of hepatocyte lipid deposition in chronic stress mice. Peer J. 7, e7668 (2019)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Tao, X.R.; Rong, J.B.; Lu, H.S.; Daugherty, A.; Shi, P.; Ke, C.L.; Zhang, Z.C.; Xu, Y.C.; Wang, J.A. Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis. J. Lipid Res. 60, 1983-1995 (2019).","DOI":"10.1194\/jlr.M093252"},{"key":"19","unstructured":"19) Fang, K.; Wu, F.; Chen, G.; Dong, H.; Li, J.; Zhao, Y.; Xu, L.; Zou, X.; Lu, F. Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK\/ACC\/CPT-1A and SREBP-1c\/FAS signaling pathways in LO2 cells. BMC Complement. Altern. Med. 19, 255 (2019)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) De Souza Mesquita, L.M.; Caria, C.R.E.P.; Santos, P.S.; Ruy, C.C.; da Silva Lima, N.; Moreira, D.K.T.; da Rocha, C.Q.; Murador, D.C.; de Rosso, V.V.; Gambero, A.; Vilegas, W. Modulatory effect of polyphenolic compounds from the mangrove tree Rhizophora mangle L. on non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice. Molecules 23, 2114 (2018).","DOI":"10.3390\/molecules23092114"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22) Sahini, N.; Borlak, J. Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis. Transl. Res. 177, 41-69 (2016).","DOI":"10.1016\/j.trsl.2016.06.003"},{"key":"22","unstructured":"23) Yoo, H.J.; Hwang, S.Y.; Choi, J.H.; Lee, H.J.; Chung, H.S.; Seo, J.A.; Kim, S.G.; Kim, N.H.; Baik, S.H.; Choi, D.S.; Choi, K.M. Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD.; Metabolic syndrome and atherosclerosis. PLoS One. 12, e0174717 (2017)."},{"key":"23","unstructured":"24) Adolph, T.E.; Grabherr, F.; Mayr, L.; Grander, C.; Enrich, B.; Moschen, A.R.; Tilg, H. Weight loss induced by bariatric surgery restricts hepatic GDF15 expression. J. Obes. 8, 7108075 (2018)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"25) Wang, X.; Chen, X.; Zhang, H.; Pang, J.; Lin, J.; Xu, X.; Yang, L.; Ma, J.; Ling, W.; Chen, Y. Circulating retinol-binding protein 4 is associated with the development and regression of non-alcoholic fatty liver disease. Diabetes Metab. 46, 119-128 (2020).","DOI":"10.1016\/j.diabet.2019.04.009"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26) Steinbrenner, H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic. Biol. Med. 65, 1538-1547 (2013).","DOI":"10.1016\/j.freeradbiomed.2013.07.016"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27) Chhabra, G.; Singh, C.K.; Ndiaye, M.A.; Fedorowicz, S.; Molot, A.; Ahmad, N. Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications. Cancer Lett. 422, 9-18 (2018).","DOI":"10.1016\/j.canlet.2018.02.025"},{"key":"27","unstructured":"28) Guo, L.; Yang, W.; Huang, Q.; Qiang, J.; Hart, J.R.; Wang, W.; Hu, J.; Zhu, J.; Liu, N.; Zhang, Y. Selenocysteine-specific mass spectrometry reveals tissue-distinct selenoproteomes and candidate selenoproteins. Cell Chem. Biol. 25, 1380-1388 (2018)."},{"key":"28","unstructured":"29) Addinsall, A.B.; Martin, S.D.; Collier, F.; Conlan, X.A.; Foletta, V.C.; Stupka, N. Differential regulation of cellular stress responses by the endoplasmic reticulum-resident Selenoprotein S (Seps1) in proliferating myoblasts versus myotubes. Physiol Rep. 6, e13926 (2018)."},{"key":"29","unstructured":"30) Liu, Y.; Zhang, W.; Zhao, J.; Lin, X.; Liu, J.; Cui, L.; Gao, Y.; Zhang, T.L.; Li, B.; Li, Y.F. Selenoprotein P as the major transporter for mercury in serum from methylmercury-poisoned rats. J. Trace Elem. Med. Biol. 50, 589-595 (2018)."},{"key":"30","doi-asserted-by":"crossref","unstructured":"31) Hu, X.; Chandler, J.D.; Orr, M.L.; Hao, L.; Liu, K.; Uppal, K.; Go, Y.M.; Jones, D.P. Selenium supplementation alters hepatic energy and fatty acid metabolism in mice. J. Nutr. 148, 675-684 (2018).","DOI":"10.1093\/jn\/nxy036"},{"key":"31","unstructured":"32) Sales, R.C.; Medeiros, P.C.; Spreafico, F.; de Velasco, P.C.; Gon\u00e7alves, F.; Mart\u00edn-Hern\u00e1ndez, R.; Mantilla-Escalante, D.C.; Gil-Zamorano, J.; Peres, W.; de Souza, S.; D\u00e1valos, A.; Tavares do Carmo, M.G. Olive oil, palm oil, and hybrid palm oil distinctly modulate liver transcriptome and induce NAFLD in mice fed a high-fat diet. Int. J. Mol. Sci. 20, 2-18 (2018)."},{"key":"32","unstructured":"33) Rashidmayvan, M.; Mohammadshahi, M.; Seyedian, S.S.; Haghighizadeh, M.H. The effect of Nigella sativa oil on serum levels of inflammatory markers, liver enzymes, lipid profile, insulin and fasting blood sugar in patients with non-alcoholic fatty liver. J. Diabetes Metab. Disord. 18, 453-459 (2019)."},{"key":"33","doi-asserted-by":"crossref","unstructured":"34) Xu, N.; Wu, X.; Luo, H.J.; Xu, F.F.; Huang, Q.H.; Wu, J.Z.; Gan, Y.X.; Li, M.Y.; Lai, Z.Q.; Lin, H.R.; Chen, J.N.; Su, Z.R.; Ai, W.P.; Liu, Y.H. Patchouli oil attenuates high fat diet-induced non-alcoholic hepatic steatosis. Planta Med. 86, 255-266 (2020).","DOI":"10.1055\/a-1087-7405"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35) Numata, M.; Yamamoto, A.; Moribayashi, A.; Yamada, H. Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi. Planta Med. 60, 356-359 (1994).","DOI":"10.1055\/s-2006-959500"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36) Misu, H.; Takamura, T.; Takayama, H.; Hayashi, H.; Matsuzawa-Nagata, N.; Kurita, S.; Ishikura, K.; Ando, H.; Takeshita, Y.; Ota, T.; Sakurai, M.; Yamashita, T.; Mizukoshi, E.; Yamashita, T.; Honda, M.; Miyamoto, K.; Kubota, T.; Kubota, N.; Kadowaki, T.; Kim, H.J.; Lee, I.K.; Minokoshi, Y.; Saito, Y.; Takahashi, K.; Yamada, Y.; Takakura, N.; Kaneko, S. A liver-derived secretory protein; selenoprotein P; causes insulin resistance. Cell Metab. 12, 483-495 (2010).","DOI":"10.1016\/j.cmet.2010.09.015"},{"key":"36","doi-asserted-by":"crossref","unstructured":"37) Gharipour, M.; Ouguerram, K.; Nazih, E.H.; Salehi, M.; Behmanesh, M.; Roohafza, H.; Hosseini, S.M.; Nezafati, P.; Dianatkhah, M.; Gharipour, A.; Haghjoo, S.; Sarrafzadegan, N.; Sadeghi, M. Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial. J. Cell Biochem. 119, 8282-8289 (2018).","DOI":"10.1002\/jcb.26844"},{"key":"37","unstructured":"38) Zheng, G.H.; Shan, Q.; Mu, J.J.; Wang, Y.J.; Zhang, Z.F.; Fan, S.H.; Hu, B.; Li, M.Q.; Xie, J.; Chen, P.; Wu, D.M.; Lu, J.; Zheng, Y.L. Purple sweet potato color attenuates kidney damage by blocking VEGFR2\/ROS\/NLRP3 signaling in high-fat diet-treated mice. Oxid. Med. Cell Longev. 22, 5189819 (2019)."},{"key":"38","unstructured":"39) Chadani, H.; Usui, S.; Inoue, O.; Kusayama, T.; Takashima, S.I.; Kato, T.; Murai, H.; Furusho, H.; Nomura, A.; Misu, H.; Takamura, T.; Kaneko, S.; Takamura, M. Endogenous selenoprotein P, a liver-derived secretory protein, mediates myocardial ischemia\/reperfusion injury in mice. Int. J. Mol. Sci. 19, 878 (2018)."},{"key":"39","doi-asserted-by":"crossref","unstructured":"40) Ishikura, K.; Misu, H.; Kumazaki, M.; Takayama, H.; Matsuzawa-Nagata, N.; Tajima, N.; Chikamoto, K.; Lan, F.; Ando, H.; Ota, T.; Sakurai, M.; Takeshita, Y.; Kato, K.; Fujimura, A.; Miyamoto, K.; Saito, Y.; Kameo, S.; Okamoto, Y.; Takuwa, Y.; Takahashi, K.; Kidoya, H.; Takakura, N.; Kaneko, S.; Takamura, T. Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Diabetologia 57, 1968-1976 (2014).","DOI":"10.1007\/s00125-014-3306-9"},{"key":"40","unstructured":"41) Tajima-Shirasaki, N.; Ishii, K.A.; Takayama, H.; Shirasaki, T.; Iwama, H.; Chikamoto, K.; Saito, Y.; Iwasaki, Y.; Teraguchi, A.; Lan, F.; Kikuchi, A.; Takeshita, Y.; Murao, K.; Matsugo, S.; Kaneko, S.; Misu, H.; Takamura, T. Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes. J. Biol. Chem. 292, 10791-10800 (2017)."}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/70\/5\/70_ess20255\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T03:45:33Z","timestamp":1619840733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/70\/5\/70_ess20255\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess20255","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}