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Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and \u03b2-cell damage in rat pancreas. Pharmacol. Res. 51, 117-123 (2005).","DOI":"10.1016\/j.phrs.2004.06.002"},{"key":"9","unstructured":"9) He, Z.X; Zhou, Z.W; Yang, Y. et al. Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus. Clin. Exp. Pharmacol. Physiol. 42, 125-138 (2015)."},{"key":"10","unstructured":"10) Olokoba, A.B; Obateru, O.A; Olokoba, L.B. Type 2 diabetes mellitus: A review of current trends. Oman Med. J. 27, 269-273 (2012)."},{"key":"11","unstructured":"11) Kumar, V; Anwar, F; Ahmed, D. et al. Paederia foetida Linn. leaf extract: An antihyperlipidemic, antihyperglycaemic and antioxidant activity. BMC Complement. Altern. Med. 14, 76 (2014)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Shivanna, N; Naika, M; Khanum, F; Kaul, V.K. 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