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Anticarcinogenic activity of Withania somnifera Dunal against Dalton\u2019s Ascitic Lymphoma. J. Ethnopharmacol. 93, 359-361 (2004)."},{"key":"6","unstructured":"6) Prasad, R; Koch, B. Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: An in vitro and in vivo study. Biomed. Res. Int. 2014, 753451 (2014)."},{"key":"7","unstructured":"7) Chockalingam, V; Suryakiran Kadali, S.D.V; Gnanasambantham, P. Antiproliferative and antioxidant activity of Aegle marmelos (Linn.) leaves in Dalton\u2019s lymphoma ascites transplanted mice. Indian J. Pharmacol. 44, 225-229 (2012)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Li, C; Du, G.H. Diosmin. in Natural Small Molecule Drugs from Plants. Springer, pp. 65-69 (2018).","DOI":"10.1007\/978-981-10-8022-7_10"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tanaka, T; Makita, H; Kawabata, K. et al. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis 18, 957-965 (1997).","DOI":"10.1093\/carcin\/18.5.957"},{"key":"10","unstructured":"10) Dholakiya, S.L; Benzeroual, K.E. Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-\u03b1 expression. Toxicol. Vitr. 25, 1039-1044 (2011)."},{"key":"11","unstructured":"11) Tahir, M; Rehman, M.U; Lateef, A. et al. Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-\u03b1 and NF-\u03baB activation. Alcohol. 47, 131-139 (2013)."},{"key":"12","unstructured":"12) Sawmiller, D; Habib, A; Li, S. et al. Diosmin reduces cerebral A\u03b2 levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. J. Neuroimmunol. 299, 98-106 (2016)."},{"key":"13","unstructured":"13) Imam, F; Al-Harbi, N.O; Al-Harbi, M.M. et al. Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-\u03baB activation against LPS-induced acute lung injury in mice. Pharmacol. Res. 102, 1-11 (2015)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Pari, L; Srinivasan, S. Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Biomed. Pharmacother. 64, 477-481 (2010).","DOI":"10.1016\/j.biopha.2010.02.001"},{"key":"15","unstructured":"15) Antony, J.J; Sithika, M.A.A; Joseph, T.A. et al. In vivo antitumor activity of biosynthesized silver nanoparticles using Ficus religiosa as a nanofactory in DAL induced mice model. Colloids Surf. B 108, 185-190 (2013)."},{"key":"16","unstructured":"16) Sriram, M.I; Kanth, S.B.M; Kalishwaralal, K; Gurunathan, S. Antitumor activity of silver nanoparticles in Dalton\u2019s lymphoma ascites tumor model. Int. J. Nanomedicine 5, 753-762 (2010)."},{"key":"17","unstructured":"17) Sunila, E.S; Kuttan, G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J. Ethnopharmacol. 90, 339-346 (2004)."},{"key":"18","unstructured":"18) Sreejamole, K.L; Radhakrishnan, C.K. Antioxidant and cytotoxic activities of ethyl acetate extract of the Indian green mussel Perna viridis. Asian J. Pharm. Clin. Res. 6, 197-201 (2013)."},{"key":"19","unstructured":"19) Dhamija, I; Kumar, N; Manjula, S.N; Parihar, V; Setty, M.M; Pai, K.S.R. Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of Premna herbacea Roxb. in Ehrlich ascites carcinoma model and Dalton\u2019s lymphoma ascites model. Exp. Toxicol. Pathol. 65, 235-242 (2013)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Harrington, K.J. The biology of cancer. Med (United Kingdom). 44 (1), 1-5 (2016).","DOI":"10.1016\/j.mpmed.2015.10.005"},{"key":"21","unstructured":"21) Stewart, B.W; Wild, C.P. World cancer report 2014. World Heal Organ 7 (2), 418-419 (2014)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Birben, E; Sahiner, U.M; Sackesen, C; Erzurum, S; Kalayci, O. Oxidative stress and antioxidant defense. World Allergy Organ J. 5, 9-19 (2012).","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"23","unstructured":"23) Sun, J; Chu, Y.F; Wu, X; Liu, R.H. Antioxidant and antiproliferative activities of common fruits. J. Agric. Food Chem. 44, 701-705 (2002)."},{"key":"24","unstructured":"24) Yuan, C; Wang, C; Wang, J. et al. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutr. Res. 36, 1243-1254 (2016)."},{"key":"25","unstructured":"25) Saha, S; Mukhopadhyay, M.K; Ghosh, P.D; Nath, D. Effect of methanolic leaf extract of Ocimum basilicum L. on benzene-induced hematotoxicity in mice. Evid. Based Complement. Altern. Med. 2012, 176385 (2012)."},{"key":"26","unstructured":"26) Rubila, S; Ranganathan, T.V; Sakthivel, K.M. Protective effect of Zingiber officinale against Dalton\u2019s Lymphoma Ascites Tumour by regulating inflammatory mediator and cytokines. Appl. Biochem. Biotechnol. 180, 1482-1496 (2016)."},{"key":"27","unstructured":"27) Kumar, V; Ahmed, D; Gupta, P.S; Anwar, F; Mujeeb, M. Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastoma malabathricum Linn. leaves in streptozotocin induced diabetic rats. BMC Complement. Altern. Med. 13, 222 (2013)."},{"key":"28","unstructured":"28) Kumar, V; Ahmed, D; Verma, A; Anwar, F; Ali, M; Mujeeb, M. Umbelliferone \u03b2-D-galactopyranoside from Aegle marmelos (L.) corr. An ethnomedicinal plant with antidiabetic, antihyperlipidemic and antioxidative activity. BMC Complement. Altern. Med. 13, 273 (2013)."},{"key":"29","unstructured":"29) Kumar, V; Bhatt, P.C; Rahman, M. et al. Melastoma malabathricum Linn attenuates complete freund\u2019s adjuvant-induced chronic inflammation in Wistar rats via inflammation response. BMC Complement. Altern. Med. 16, 510 (2016)."},{"key":"30","unstructured":"30) Merlin, N.J; Parthasarathy, V. Potential antitumour activity of Gmelina asiatica aerial parts against dalton ascites lymphoma in mice. Asian J. Chem. 22, 3193-3199 (2010)."},{"key":"31","unstructured":"31) Balamurugan, K; Nishanthini, A; Mohan, V.R. Anticancer activity of ethanol extract of Melastoma malabathricum L. Leaf against dalton ascites lymphoma. J. Pharm. Sci. Res. 5 (5), 111-114 (2013)."},{"key":"32","unstructured":"32) Augustine, B.B; Dash, S; Lahkar, M; Sarma, U; Samudrala, P.K; Thomas, J.M. Leucas aspera inhibits the Dalton\u2019s ascitic lymphoma in Swiss albino mice: A preliminary study exploring possible mechanism of action. Pharmacogn. Mag. 10 (38), 118-124 (2014)."},{"key":"33","unstructured":"33) Thavamani, B.S; Mathew, M; Palaniswamy, D.S. 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