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PLoS One 10, e0120391 (2015).","DOI":"10.1371\/journal.pone.0120391"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Rognlien, M.; Duncan, S.E.; O\u2019Keefe, S.F.; Eigel, W.N. Consumer perception and sensory effect of oxidation in savory-flavored yogurt enriched with n-3 lipids. J. Dairy Sci. 95, 1690-1698 (2012).","DOI":"10.3168\/jds.2011-5010"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Chen, I.S.; Hotta, S.S.; Ikeda, I.; Cassidy, M.M.; Sheppard, A.J. et al. Digestion, absorption and effects on cholesterol absorption of menhaden oil, fish oil concentrate and corn oil by rats. J. Nutr. 117, 1676-1680 (1987).","DOI":"10.1093\/jn\/117.10.1676"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Visioli, F.; Ris\u00e9, P.; Barassi, M.C.; Marangoni, F.; Galli, C. Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. Lipids 38, 415-418 (2003).","DOI":"10.1007\/s11745-003-1077-x"},{"key":"14","unstructured":"14) Harris, W.S.; Williams, G.G. Emulsification enhances the absorption of fish oil in man. in Health Effects of Fish Oils (Chandra, R.K. ed.). ARTS Biomedical Publishing, pp. 211-218 (1989)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Raatz, S.K.; Redmon, J.B.; Wimmergren, N.; Donadio, J.V.; Bibus, D.M. Enhanced absorption of n-3 fatty acids from emulsified compared with encapsulated fish oil. J. Am. Diet. Assoc. 109, 1076-1081 (2009).","DOI":"10.1016\/j.jada.2009.03.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ichinose, T.; Kato, M.; Matsuzaki, K.; Tanabe, Y.; Tachibana, N. et al. Beneficial effects of docosahexaenoic acid-enriched milk beverage intake on cognitive function in healthy elderly Japanese: A 12-month randomized, double-blind, placebo-controlled trial. J. Funct. Foods 74, 104198 (2020).","DOI":"10.1016\/j.jff.2020.104195"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Chang, K.H.; Chung, C.J.; Lin, C.L.; Sung, F.C.; Wu, T.N. et al. Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age (Dordr.) 36, 967-975 (2014).","DOI":"10.1007\/s11357-013-9608-x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Tan, Z.S.; Seshadri, S.; Beiser, A.; Zhang, Y.; Felson, D. et al. Bone mineral density and the risk of Alzheimer\u2019s disease. Arch. Neurol. 62, 107-111 (2005).","DOI":"10.1001\/archneur.62.1.107"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Loskutova, N.; Honea, R.A.; Vidomi, E.D.; Brooks, W.M.; Burns, J.M. Bone density and brain atrophy in early Alzheimer\u2019s disease. J. Alzheimers Dis. 18, 777-785 (2009).","DOI":"10.3233\/JAD-2009-1185"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Farina, E.K.; Kiel, D.P.; Roubenoff, R.; Schaefer, E.J.; Cupples, L.A. et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am. J. Clin. Nutr. 93, 1142-1151 (2011).","DOI":"10.3945\/ajcn.110.005926"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Rozner, R.; Vernikov, J.; Griess-Fishheimer, S.; Travinsky, T.; Penn, S. et al. The role of omega-3 polyunsaturated fatty acids from different sources in bone development. Nutrients 12, 3494 (2020).","DOI":"10.3390\/nu12113494"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Hashimoto, M.; Matsuzaki, K.; Kato, S.; Hossain, S.; Ohno, M. et al. Twelve-month studies on perilla oil intake in Japanese adults \u2013 Possible supplement for mental health. Foods 9, 530 (2020).","DOI":"10.3390\/foods9040530"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Hashimoto, M.; Tanabe, Y.; Hossain, S.; Matsuzaki, K.; Ohno, M. et al. Intake of alpha-linolenic acid-rich perilla frutescens leaf powder decreases home blood pressure and serum oxidized low-density lipoprotein in Japanese adults. Molecules 25, 2099 (2020).","DOI":"10.3390\/molecules25092099"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Sumiyoshi, E.; Matsuzaki, K.; Sugimoto, N.; Tanabe, Y.; Hara, T. et al. Sub-chronic consumption of dark chocolate enhances cognitive function and releases nerve growth factors: A parallel-group randomized trial. Nutrients 11, 2800 (2019).","DOI":"10.3390\/nu11112800"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Yamazaki, K.; Kushida, K.; Ohmura, A.; Sano, M.; Inoue, T. et al. Ultrasound bone densitometry of the os calcis in Japanese women. Osteoporos Int. 4, 220-225 (1994).","DOI":"10.1007\/BF01623242"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Hashimoto, M.; Kato, S.; Tanabe, Y.; Katakura, M.; Al Mamun, A. et al. Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes. Geriatr. Gerontol. Int. 17, 330-337 (2017).","DOI":"10.1111\/ggi.12691"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Folstein, M.F.; Folstein, S.E.; McHugh, P.R. \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189-198 (1975).","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"28","unstructured":"28) Imai, Y.; Hasegawa, K. The revised Hasegawa\u2019s dementia scale (HDS-R) - Evaluation of its usefulness as a screening test for dementia. J. Hong Kong Coll. Psychiatr. 4 (Suppl 2), 20-24 (1994)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Fujiwara, Y.; Suzuki, H.; Yasunaga, M.; Sugiyama, M.; Ijuin, M. et al. Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment. Geriatr. Gerontol. Int. 10, 225-232 (2010).","DOI":"10.1111\/j.1447-0594.2010.00585.x"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Garaiova, I.; Guschina, I.A.; Plummer, S.F.; Tang, J.; Wan, D. et al. A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. Nutr. J. 6, 4 (2007).","DOI":"10.1186\/1475-2891-6-4"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Bo, Y.; Zhang, X.; Wang, Y.; You, J.; Cui, H. et al. 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Neurol. 63, 1402-1048 (2006).","DOI":"10.1001\/archneur.63.10.1402"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Avallone, R.; Vitale, G.; Bertolotti, M. Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials. Int. J. Mol. Sci. 20, 4256 (2019).","DOI":"10.3390\/ijms20174256"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Guerrero-Berroa, E.; Luo, X.; Schmeidler, J.; Rapp, M.A.; Dahlman, K. et al. The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly. Int. J. Geriat. Psychiatry 24, 1429-1437 (2009).","DOI":"10.1002\/gps.2282"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Kang, H.G.; Park, H.Y.; Ryu, H.U.; Suk, S.H. Bone mineral loss and cognitive impairment: the PRESENT project. Medicine (Baltimore) 97, e12755 (2018).","DOI":"10.1097\/MD.0000000000012755"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Sohrabi, H.R.; Bates, K.A.; Weinborn, M.; Bucks, R.S.; Rainey-Smith, S.R. et al. Bone mineral density, adiposity, and cognitive functions. Front. Aging Neurosci. 7, 16 (2015).","DOI":"10.3389\/fnagi.2015.00016"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Shidara, K.; Inaba, M.; Okuno, S.; Yamada, S.; Kumeda, Y. et al. Serum levels of TRAP3b, a new bone resorption marker of cortical bone loss in hemodialysis patients. Calcif. Tissue Int. 82, 278-287 (2008).","DOI":"10.1007\/s00223-008-9127-4"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Yamada, S.; Inaba, M.; Kurajoh, M.; Shidara, K.; Imanishi, Y. et al. Utility of serum tartrate-resistant acid phosphate as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction. Clin. Ensocrinol. (Oxf.) 69, 189-196 (2008).","DOI":"10.1111\/j.1365-2265.2008.03187.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Bonnick, S.L.; Shulman, L. Monitoring osteoporosis therapy: Bone mineral density, bone turnover markers, or both? Am. J. Med. 119 (4 Suppl 1), S25-S31 (2006).","DOI":"10.1016\/j.amjmed.2005.12.020"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Ishima, Y. Osteoporosis and lifestyle. J. Nutr. Sci. Vitaminol. 61, S139-S141 (2015).","DOI":"10.3177\/jnsv.61.S139"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Paunescu, A.C.; Ayotte, P.; Dewailly, E.; Dodin, S.; Pedersen, H.S. et al. Polyunsaturated fatty acids and calcaneal ultrasound parameters among Inuit women from Nuuk (Greenland) : A longitudinal study. Int. J. Circumpolar Health 72, 20988 (2003).","DOI":"10.3402\/ijch.v72i0.20988"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Kis, B.; Snipes, J.A.; Busija, D.W. Acetaminophen and the cyclooxygenase-3 puzzle: Sorting out facts, fictions, and uncertainties. J. Pharmacol. Exp. Ther. 315, 1-7 (2005).","DOI":"10.1124\/jpet.105.085431"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Weiler, H.A.; Fitzpatrick-Wong, S.C. Modulation of essential (n-6) : (n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. J. Nutr. 132, 2667-2672 (2002).","DOI":"10.1093\/jn\/132.9.2667"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Casado-D\u00edaz, A.; Santiago-Mora, R.; Dorado, G.; Quesada-G\u00f3mez, J.M. The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis. Osteoporos Int. 24, 1647-1661 (2013).","DOI":"10.1007\/s00198-012-2138-z"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Griel, A.E.; Kris-Etherton, P.M.; Hilpert, K.F.; Zhao, G.; West, S.G. et al. 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