{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:54Z","timestamp":1790899254043,"version":"4.1.0"},"reference-count":35,"publisher":"Japan Oil Chemists' Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2022]]},"DOI":"10.5650\/jos.ess22077","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T22:10:00Z","timestamp":1657059000000},"page":"1097-1106","source":"Crossref","is-referenced-by-count":17,"title":["Extraction of Fucoxanthin Isomers from the Edible Brown Seaweed &lt;i&gt;Undaria pinnatifida&lt;\/i&gt; Using Supercritical CO&lt;sub&gt;2&lt;\/sub&gt;: Effects of Extraction Conditions on Isomerization and Recovery of Fucoxanthin"],"prefix":"10.5650","volume":"71","author":[{"given":"Masaki","family":"Honda","sequence":"first","affiliation":[{"name":"Faculty of Science & Technology, Meijo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Murakami","sequence":"additional","affiliation":[{"name":"Faculty of Science & Technology, Meijo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo","family":"Takasu","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Materials Process Engineering, Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Maoka, T. Carotenoids as natural functional pigments. J. Nat. Med. 74, 1-16 (2020).","DOI":"10.1007\/s11418-019-01364-x"},{"key":"2","unstructured":"2) Maeda, H.; Tsukui, T.; Sashima, T.; Hosokawa, M.; Miyashita, K. Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac. J. Clin. Nutr. 17, 196-199 (2008)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Peng, J.; Yuan, J.P.; Wu, C.F.; Wang, J.H. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar. Drugs 9, 1806-1828 (2011).","DOI":"10.3390\/md9101806"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hosokawa, M. Health-promoting functions of the marine carotenoid fucoxanthin. in Carotenoids: Biosynthetic and Biofunctional Approaches (Misawa, N. ed.). Elsevier, pp. 273-284 (2021).","DOI":"10.1007\/978-981-15-7360-6_25"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Maeda, H. Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review. J. Oleo Sci. 64, 125-132 (2015).","DOI":"10.5650\/jos.ess14226"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Hosokawa, M.; Kudo, M.; Maeda, H.; Kohno, H.; Tanaka, T.; Miyashita, K. Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPAR\u03b3 ligand, troglitazone, on colon cancer cells. Biochim. Biophys. Acta Gen. Subj. 1675, 113-119 (2004).","DOI":"10.1016\/j.bbagen.2004.08.012"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Arora, N.; Philippidis, G.P. Fucoxanthin production from diatoms: Current advances and challenges. in Algae (Mandotra, S.K.; Upadhyay, A.K.; Ahluwalia, A.S. eds.). Springer, pp. 227-242 (2021).","DOI":"10.1007\/978-981-15-7518-1_10"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Saini, R.K.; Keum, Y.S. Carotenoid extraction methods: A review of recent developments. Food Chem. 240, 90-103 (2018).","DOI":"10.1016\/j.foodchem.2017.07.099"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Mezzomo, N.; Ferreira, S.R. Carotenoids functionality, sources, and processing by supercritical technology: A review. J. Chem. 2016, 3164312 (2016).","DOI":"10.1155\/2016\/3164312"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Li, X.; Wang, X.; Duan, C.; Yi, S.; Gao, Z. et al. Biotechnological production of astaxanthin from the microalga Haematococcus pluvialis. Biotechnol. Adv. 43, 107602 (2020).","DOI":"10.1016\/j.biotechadv.2020.107602"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Honda, M. Carotenoid isomers: A systematic review of the analysis, biological activity, physicochemical property, and methods for isomerization. in Studies in Natural Products Chemistry, Volume 68 (Rahman, A. ed.). Elsevier, pp. 173-220 (2021).","DOI":"10.1016\/B978-0-12-819485-0.00002-5"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Honda, M. Application of E\/Z-isomerization technology for enhancing processing efficiency, health-promoting effects, and usability of carotenoids: A review and future perspectives. J. Oleo Sci. 71, 151-165 (2022).","DOI":"10.5650\/jos.ess21338"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Honda, M.; Takasu, S.; Nakagawa, K.; Tsuda, T. Differences in bioavailability and tissue accumulation efficiency of (all-E)- and (Z)-carotenoids: A comparative study. Food Chem. 361, 130119 (2021).","DOI":"10.1016\/j.foodchem.2021.130119"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Nakazawa, Y.; Sashima, T.; Hosokawa, M.; Miyashita, K. Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines. J. Funct. Foods 1, 88-97 (2009).","DOI":"10.1016\/j.jff.2008.09.015"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Quitain, A.T.; Kai, T.; Sasaki, M.; Goto, M. Supercritical carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. J. Agric. Food Chem. 61, 5792-5797 (2013).","DOI":"10.1021\/jf400740p"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Conde, E.; Moure, A.; Dom\u00ednguez, H. Supercritical CO<sub>2<\/sub> extraction of fatty acids, phenolics and fucoxanthin from freeze-dried Sargassum muticum. J. Appl. Phycol. 27, 957-964 (2015).","DOI":"10.1007\/s10811-014-0389-0"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Honda, M.; Murakami, K.; Watanabe, Y.; Higashiura, T.; Fukaya, T. et al. The E\/Z isomer ratio of lycopene in foods and effect of heating with edible oils and fats on isomerization of (all-E)-lycopene. Eur. J. Lipid Sci. Technol. 119, 1600389 (2017).","DOI":"10.1002\/ejlt.201600389"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Honda, M.; Watanabe, Y.; Murakami, K.; Takemura, R.; Fukaya, T. et al. Thermal isomerization pre-treatment to improve lycopene extraction from tomato pulp. LWT 86, 69-75 (2017).","DOI":"10.1016\/j.lwt.2017.07.046"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Honda, M.; Watanabe, Y.; Murakami, K.; Hoang, N.N.; Wahyudiono et al. Enhanced lycopene extraction from gac (Momordica cochinchinensis Spreng.) by the Z-isomerization induced with microwave irradiation pre-treatment. Eur. J. Lipid Sci. Technol. 120, 1700293 (2018).","DOI":"10.1002\/ejlt.201700293"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Saravana, P.S.; Getachew, A.T.; Cho, Y.J.; Choi, J.H.; Park, Y.B. et al. Influence of co-solvents on fucoxanthin and phlorotannin recovery from brown seaweed using supercritical CO<sub>2<\/sub>. J. Supercrit. Fluids 120, 295-303 (2017).","DOI":"10.1016\/j.supflu.2016.05.037"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Crupi, P.; Toci, A.T.; Mangini, S.; Wrubl, F.; Rodolfi, L. et al. Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization. Rapid Commun. Mass Spectrom. 27, 1027-1035 (2013).","DOI":"10.1002\/rcm.6531"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Zhao, D.; Kim, S.M.; Pan, C.H.; Chung, D. Effects of heating, aerial exposure and illumination on stability of fucoxanthin in canola oil. Food Chem. 145, 505-513 (2014).","DOI":"10.1016\/j.foodchem.2013.08.045"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Zhu, J.; Sun, X.; Chen, X.; Wang, S.; Wang, D. Chemical cleavage of fucoxanthin from Undaria pinnatifida and formation of apo-fucoxanthinones and apo-fucoxanthinals identified using LC-DAD-APCI-MS\/MS. Food Chem. 211, 365-373 (2016).","DOI":"10.1016\/j.foodchem.2016.05.064"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Zhang, Y.; Fang, H.; Xie, Q.; Sun, J.; Liu, R.; Hong, Z.; Yi, R.; Wu, H. Comparative evaluation of the radical-scavenging activities of fucoxanthin and its stereoisomers. Molecules 19, 2100-2113 (2014).","DOI":"10.3390\/molecules19022100"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Honda, M.; Takahashi, N.; Kuwa, T.; Takehara, M.; Inoue, Y.; Kumagai, T. Spectral characterisation of Z-isomers of lycopene formed during heat treatment and solvent effects on the E\/Z isomerisation process. Food Chem. 171, 323-329 (2015).","DOI":"10.1016\/j.foodchem.2014.09.004"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Honda, M.; Murakami, K.; Zhang, Y.; Goto, M. Rapid and continuous astaxanthin isomerization in subcritical ethanol. Ind. Eng. Chem. Res. 60, 14060-14068 (2021).","DOI":"10.1021\/acs.iecr.1c02101"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Yuan, J.P.; Chen, F. Kinetics for the reversible isomerization reaction of trans-astaxanthin. Food Chem. 73, 131-137 (2001).","DOI":"10.1016\/S0308-8146(01)00107-8"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Honda, M.; Kudo, T.; Kuwa, T.; Higashiura, T.; Fukaya, T. et al. Isolation and spectral characterization of thermally generated multi-Z-isomers of lycopene and the theoretically preferred pathway to di-Z-isomers. Biosci. Biotechnol. Biochem. 81, 365-371 (2017).","DOI":"10.1080\/09168451.2016.1249454"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Guo, W.H.; Tu, C.Y.; Hu, C.H. Cis-trans isomerizations of \u03b2-carotene and lycopene: A theoretical study. J. Phys. Chem. B 112, 12158-12167 (2008).","DOI":"10.1021\/jp8019705"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Honda, M.; Murakami, K.; Zhang, Y.; Goto, M. High-efficiency lycopene isomerization with subcritical ethyl acetate in a continuous-flow reactor. J. Supercrit. Fluids 178, 105383 (2021).","DOI":"10.1016\/j.supflu.2021.105383"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) L\u00f3pez-Padilla, A.; Ruiz-Rodriguez, A.; Reglero, G.; Fornari, T. Study of the diffusion coefficient of solute-type extracts in supercritical carbon dioxide: Volatile oils, fatty acids and fixed oils. J. Supercrit. Fluids 109, 148-156 (2016).","DOI":"10.1016\/j.supflu.2015.11.017"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Durante, M.; Lenucci, M.S.; Mita, G. Supercritical carbon dioxide extraction of carotenoids from pumpkin (Cucurbita spp.) : A review. Int. J. Mol. Sci. 15, 6725-6740 (2014).","DOI":"10.3390\/ijms15046725"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kim, S.M.; Jung, Y.J.; Kwon, O.N.; Cha, K.H.; Um, B.H. et al. A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Appl. Biochem. Biotechnol. 166, 1843-1855 (2012).","DOI":"10.1007\/s12010-012-9602-2"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kim, S.M.; Kang, S.W.; Kwon, O.N.; Chung, D.; Pan, C.H. Fucoxanthin as a major carotenoid in Isochrysis aff. galbana: Characterization of extraction for commercial application. J. Korean Soc. Appl. Biol. Chem. 55, 477-483 (2012).","DOI":"10.1007\/s13765-012-2108-3"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Billakanti, J.M.; Catchpole, O.J.; Fenton, T.A.; Mitchell, K.A.; MacKenzie, A.D. Enzyme-assisted extraction of fucoxanthin and lipids containing polyunsaturated fatty acids from Undaria pinnatifida using dimethyl ether and ethanol. Process Biochem. 48, 1999-2008 (2013).","DOI":"10.1016\/j.procbio.2013.09.015"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/71\/8\/71_ess22077\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T04:38:39Z","timestamp":1659760719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/71\/8\/71_ess22077\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess22077","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"ess22077"}}