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Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1, 549-553 (1982).","DOI":"10.1002\/j.1460-2075.1982.tb01207.x"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) Foltran, R.B.; Diaz, S.L. BDNF isoforms: A round trip ticket between neurogenesis and serotonin? J. Neurochem. 138, 204-221 (2016). doi: 10.1111\/jnc.13658","DOI":"10.1111\/jnc.13658"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Lu, B. BDNF and activity-dependent synaptic modulation. Learn. Mem. 10, 86-98 (2003). doi: 10.1101\/lm. 54603","DOI":"10.1101\/lm.54603"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) Lu, B.; Pang, P.T.; Woo, N.H. The yin and yang of neurotrophin action. Nat. Rev. Neurosci. 6, 603-614 (2005). doi: 10.1038\/nrn1726","DOI":"10.1038\/nrn1726"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Seidah, N.G.; Benjannet, S.; Pareek, S.; Chretien, M.; Murphy, R.A. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Lett. 379, 247-250 (1996).","DOI":"10.1016\/0014-5793(95)01520-5"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Wetsel, W.C.; Rodriguiz, R.M.; Guillemot, J.; Rousselet, E.; Essalmani, R. et al. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proc. Natl. Acad. Sci. U S A 110, 17362-17367 (2013). doi: 10.1073\/pnas.1314698110","DOI":"10.1073\/pnas.1314698110"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7) Mattson, M.P.; Maudsley, S.; Martin, B. BDNF and 5-HT: A dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 27, 589-594 (2004). doi: 10.1016\/j.tins.2004.08.001","DOI":"10.1016\/j.tins.2004.08.001"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) Zhao, H.; Alam, A.; San, C.Y.; Eguchi, S.; Chen, Q. et al. 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Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson\u2019s disease. Neurosci. Lett. 270, 45-48 (1999).","DOI":"10.1016\/S0304-3940(99)00463-2"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14) Peng, S.; Wuu, J.; Mufson, E.J.; Fahnestock, M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer\u2019s disease. J. Neurochem. 93, 1412-1421 (2005). doi: 10.1111\/j.1471-4159.2005.03135.x","DOI":"10.1111\/j.1471-4159.2005.03135.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Weickert, C.S.; Hyde, T.M.; Lipska, B.K.; Herman, M.M.; Weinberger, D.R. et al. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol. 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Higher BDNF serum levels predict slower cognitive decline in Alzheimer\u2019s disease patients. Int. J. Neuropsychopharmacol. 14, 399-404 (2011). doi: 10.1017\/s1461145710001008","DOI":"10.1017\/S1461145710001008"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Tsukahara, T.; Takeda, M.; Shimohama, S.; Ohara, O.; Hashimoto, N. Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys. Neurosurgery 37, 733-739; discussion 739-741 (1995). doi: 10.1227\/00006123-199510000-00018","DOI":"10.1227\/00006123-199510000-00018"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Duman, R.S.; Heninger, G.R.; Nestler, E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry 54, 597-606 (1997).","DOI":"10.1001\/archpsyc.1997.01830190015002"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21) Hoshaw, B.A.; Malberg, J.E.; Lucki, I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res. 1037, 204-208 (2005). doi: 10.1016\/j.brainres.2005.01.007","DOI":"10.1016\/j.brainres.2005.01.007"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Shirayama, Y.; Chen, A.C.; Nakagawa, S.; Russell, D.S.; Duman, R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 22, 3251-3261 (2002). doi: 20026292","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Yankelevitch-Yahav, R.; Franko, M.; Huly, A.; Doron, R. The forced swim test as a model of depressive-like behavior. J. Vis. Exp. (97), e52587 (2015). doi: 10.3791\/ 52587","DOI":"10.3791\/52587-v"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24) Lu, B.; Nagappan, G.; Guan, X.; Nathan, P.J.; Wren, P. BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat. Rev. Neurosci. 14, 401-416 (2013). doi: 10.1038\/nrn3505","DOI":"10.1038\/nrn3505"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Lu, B.; Nagappan, G.; Lu, Y. BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb. Exp. Pharmacol. 220, 223-250 (2014). doi: 10.1007\/ 978-3-642-45106-5_9","DOI":"10.1007\/978-3-642-45106-5_9"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26) Rohe, M.; Synowitz, M.; Glass, R.; Paul, S.M.; Nykjaer, A. et al. Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J. Neurosci. 29, 15472-15478 (2009). doi: 10.1523\/jneurosci.3960-09.2009","DOI":"10.1523\/JNEUROSCI.3960-09.2009"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) Jeremic, D.; Jim\u00e9nez-D\u00edaz, L.; Navarro-L\u00f3pez, J.D. Past, present and future of therapeutic strategies against amyloid-\u03b2 peptides in Alzheimer\u2019s disease: A systematic review. Ageing Res. Rev. 72, 101496 (2021). doi: 10.1016\/j.arr.2021.101496","DOI":"10.1016\/j.arr.2021.101496"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28) Zhou, J.P.; Feng, Z.G.; Yuan, B.L.; Yu, S.Z.; Li, Q. et al. Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice. Brain Res. 1191, 12-19 (2008). doi: 10.1016\/j.brainres.2007.10.097","DOI":"10.1016\/j.brainres.2007.10.097"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29) Nam, J.H.; Leem, E.; Jeon, M.T.; Jeong, K.H.; Park, J.W. et al. Induction of GDNF and BDNF by hRheb (S16H) transduction of SNpc neurons: neuroprotective mechanisms of hRheb (S16H) in a model of Parkinson\u2019s disease. Mol. Neurobiol. 51, 487-499 (2015). doi: 10.1007\/s12035-014-8729-2","DOI":"10.1007\/s12035-014-8729-2"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Hofer, M.; Pagliusi, S.R.; Hohn, A.; Leibrock, J.; Barde, Y.A. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9, 2459-2464 (1990).","DOI":"10.1002\/j.1460-2075.1990.tb07423.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Yan, Q.; Rosenfeld, R.D.; Matheson, C.R.; Hawkins, N.; Lopez, O.T. et al. Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience 78, 431-448 (1997). doi: 10. 1016\/s0306-4522 (96) 00613-6","DOI":"10.1016\/S0306-4522(96)00613-6"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Ernfors, P.; Wetmore, C.; Olson, L.; Persson, H. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5, 511-526 (1990). doi: 10.1016\/ 0896-6273 (90) 90090-3","DOI":"10.1016\/0896-6273(90)90090-3"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33) Katoh-Semba, R.; Takeuchi, I.K.; Semba, R.; Kato, K. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. J. Neurochem. 69, 34-42 (1997). doi: 10.1046\/j.1471-4159.1997.69010034.x","DOI":"10.1046\/j.1471-4159.1997.69010034.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Maisonpierre, P.C.; Le Beau, M.M.; Espinosa, R., 3rd; Ip, N.Y.; Belluscio, L. et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations. Genomics 10, 558-568 (1991). doi: 10.1016\/0888-7543 (91) 90436-i","DOI":"10.1016\/0888-7543(91)90436-I"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35) Matthews, V.B.; Astr\u00f6m, M.B.; Chan, M.H.; Bruce, C.R.; Krabbe, K.S. et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia 52, 1409-1418 (2009). doi: 10.1007\/s00125-009-1364-1","DOI":"10.1007\/s00125-009-1364-1"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Nakahashi, T.; Fujimura, H.; Altar, C.A.; Li, J.; Kambayashi, J. et al. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett. 470, 113-117 (2000). doi: 10.1016\/s0014-5793 (00) 01302-8","DOI":"10.1016\/S0014-5793(00)01302-8"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Pan, W.; Banks, W.A.; Fasold, M.B.; Bluth, J.; Kastin, A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37, 1553-1561 (1998).","DOI":"10.1016\/S0028-3908(98)00141-5"},{"key":"38","doi-asserted-by":"publisher","unstructured":"38) Nakajima, K.; Oiso, S.; Kariyazono, H. Brain-derived neurotrophic factor up-regulation by the methanol extract of foxtail millet in human peripheral cells. J. Nutr. Sci. Vitaminol. (Tokyo) 66, 284-288 (2020). doi: 10.3177\/jnsv.66.284","DOI":"10.3177\/jnsv.66.284"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Nakajima, K.; Okubo, S.; Oiso, S. Identification of traditional Japanese Kampo medicines and crude drugs that upregulate brain-derived neurotrophic factor in human peripheral cells. Acta Neurobiol. Exp. (Wars.) 81, 393-404 (2021). doi: 10.21307\/ane-2021-042","DOI":"10.55782\/ane-2021-042"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40) Matsuo, Y.; Akita, K.; Taguchi, H.; Fujii, S.; Yoshie-Stark, Y. et al. Utilization and evaluation of Citrus natsudaidai peel waste as a source of natural food additives. Food Chem. 373, 131464 (2021). doi: 10.1016\/j.foodchem.2021.131464","DOI":"10.1016\/j.foodchem.2021.131464"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Nakayama, N.; Yamaura, K.; Shimada, M.; Ueno, K. Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. Pharmacognosy Res. 3, 155-159 (2011). doi: 10.4103\/0974-8490.84999","DOI":"10.4103\/0974-8490.84999"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Yamaura, K.; Nakayama, N.; Shimada, M.; Ueno, K. Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice. Pharmacognosy Res. 4, 234-236 (2012). doi: 10.4103\/0974-8490.102274","DOI":"10.4103\/0974-8490.102274"},{"key":"43","doi-asserted-by":"publisher","unstructured":"43) Polacchini, A.; Metelli, G.; Francavilla, R.; Baj, G.; Florean, M. et al. A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays. Sci. Rep. 5, 17989 (2015). doi: 10.1038\/srep17989","DOI":"10.1038\/srep17989"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44) Furukawa, Y.; Washimi, Y.S.; Hara, R.I.; Yamaoka, M.; Okuyama, S. et al. Citrus auraptene induces expression of brain-derived neurotrophic factor in neuro2a cells. Molecules 25 (2020). doi: 10.3390\/molecules25051117","DOI":"10.3390\/molecules25051117"},{"key":"45","doi-asserted-by":"publisher","unstructured":"45) Kosari-Nasab, M.; Shokouhi, G.; Ghorbanihaghjo, A.; Abbasi, M.M.; Salari, A.A. Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury. Life Sci. 213, 198-205 (2018). doi: 10.1016\/j.lfs.2018.10.040","DOI":"10.1016\/j.lfs.2018.10.040"},{"key":"46","doi-asserted-by":"publisher","unstructured":"46) Li, J.; Zhou, Y.; Liu, B.B.; Liu, Q.; Geng, D. et al. Nobiletin ameliorates the deficits in hippocampal BDNF, TrkB, and synapsin I induced by chronic unpredictable mild stress. Evid. Based Complement. Alternat. Med. 2013, 359682 (2013). doi: 10.1155\/2013\/359682","DOI":"10.1155\/2013\/359682"},{"key":"47","doi-asserted-by":"publisher","unstructured":"47) Rong, W.; Wang, J.; Liu, X.; Jiang, L.; Wei, F. et al. Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. Neurochem. Res. 37, 1615-1623 (2012). doi: 10.1007\/s11064-012-0756-7","DOI":"10.1007\/s11064-012-0756-7"},{"key":"48","doi-asserted-by":"publisher","unstructured":"48) Sawamoto, A.; Okuyama, S.; Yamamoto, K.; Amakura, Y.; Yoshimura, M. et al. 3,5,6,7,8,3\u2032,4\u2032-Heptamethoxyflavone, a citrus flavonoid, ameliorates corticosterone-induced depression-like behavior and restores brain-derived neurotrophic factor expression, neurogenesis, and neuroplasticity in the hippocampus. Molecules 21, 541 (2016). doi: 10.3390\/molecules21040541","DOI":"10.3390\/molecules21040541"},{"key":"49","doi-asserted-by":"publisher","unstructured":"49) Nogata, Y.; Sakamoto, K.; Shiratsuchi, H.; Ishii, T.; Yano, M. et al. Flavonoid composition of fruit tissues of citrus species. Biosci. Biotechnol. Biochem. 70, 178-192 (2006). doi: 10.1271\/bbb.70.178","DOI":"10.1271\/bbb.70.178"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Takahashi, Y.; Inaba, N.; Kuwahara, S.; Kuki, W.; Yamane, K. et al. Rapid and convenient method for preparing aurapten-enriched product from hassaku peel oil: Implications for cancer-preventive food additives. J. Agric. Food Chem. 50, 3193-3196 (2002). doi: 10. 1021\/jf011628b","DOI":"10.1021\/jf011628b"},{"key":"51","unstructured":"51) Li, F.; Meng, F.; Xiong, Z.; Li, Y.; Liu, R. et al. Stimulative activity of Drynaria fortunei (Kunze) J. Sm. extracts and two of its flavonoids on the proliferation of osteoblastic like cells. Pharmazie 61, 962-965 (2006)."},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Finkbeiner, S.; Tavazoie, S.F.; Maloratsky, A.; Jacobs, K.M.; Harris, K.M. et al. CREB: a major mediator of neuronal neurotrophin responses. Neuron 19, 1031-1047 (1997). doi: 10.1016\/s0896-6273 (00) 80395-5","DOI":"10.1016\/S0896-6273(00)80395-5"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Lonze, B.E.; Ginty, D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron. 35, 605-623 (2002). doi: 10.1016\/s0896-6273 (02) 00828-0","DOI":"10.1016\/S0896-6273(02)00828-0"},{"key":"54","doi-asserted-by":"publisher","unstructured":"54) Pruunsild, P.; Sepp, M.; Orav, E.; Koppel, I.; Timmusk, T. Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene. J. Neurosci. 31, 3295-3308 (2011). doi: 10.1523\/jneurosci.4540-10.2011","DOI":"10.1523\/JNEUROSCI.4540-10.2011"},{"key":"55","doi-asserted-by":"publisher","unstructured":"55) Bl\u00fcthgen, N.; van Bentum, M.; Merz, B.; Kuhl, D.; Hermey, G. Profiling the MAPK\/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo. Sci. Rep. 7, 45101 (2017). doi: 10.1038\/srep45101","DOI":"10.1038\/srep45101"},{"key":"56","doi-asserted-by":"publisher","unstructured":"56) Funahashi, Y.; Ariza, A.; Emi, R.; Xu, Y.; Shan, W. et al. Phosphorylation of Npas4 by MAPK regulates reward-related gene expression and behaviors. Cell Rep. 29, 3235-3252.e9 (2019). doi: 10.1016\/j.celrep.2019.10.116","DOI":"10.1016\/j.celrep.2019.10.116"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Gonzalez, G.A.; Montminy, M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680 (1989). doi: 10.1016\/0092-8674 (89) 90013-5","DOI":"10.1016\/0092-8674(89)90013-5"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Liu, S.H.; Lai, Y.L.; Chen, B.L.; Yang, F.Y. Ultrasound enhances the expression of brain-derived neurotrophic factor in astrocyte through activation of TrkB-Akt and calcium-CaMK signaling pathways. Cereb. Cortex 27, 3152-3160 (2017). doi: 10.1093\/cercor\/bhw169","DOI":"10.1093\/cercor\/bhw169"},{"key":"59","doi-asserted-by":"publisher","unstructured":"59) Speckmann, T.; Sabatini, P.V.; Nian, C.; Smith, R.G.; Lynn, F.C. Npas4 transcription factor expression is regulated by calcium signaling pathways and prevents tacrolimus-induced cytotoxicity in pancreatic beta cells. J. Biol. Chem. 291, 2682-2695 (2016). doi: 10.1074\/jbc.M115.704098","DOI":"10.1074\/jbc.M115.704098"},{"key":"60","doi-asserted-by":"publisher","unstructured":"60) Furukawa, Y.; Watanabe, S.; Okuyama, S.; Nakajima, M. Neurotrophic effect of citrus auraptene: neuritogenic activity in PC12 cells. Int. J. Mol. Sci. 13, 5338-5347 (2012). doi: 10.3390\/ijms13055338","DOI":"10.3390\/ijms13055338"},{"key":"61","doi-asserted-by":"publisher","unstructured":"61) Kinoshita, K.; Murase, S. Studies on the constituents of orange oil of Citrus natsudaidai Hayata. I. Structure of natsudaidain: 3-hydroxy-5,6,7,8,3\u2032,4\u2032-hexamethoxyflavone. Yakugaku Zasshi 91, 1105-1108 (1971). doi: 10.1248\/yakushi1947.91.10_1105","DOI":"10.1248\/yakushi1947.91.10_1105"},{"key":"62","doi-asserted-by":"publisher","unstructured":"62) Sawamoto, A.; Okuyama, S.; Amakura, Y.; Yoshimura, M.; Yamada, T. et al. 3,5,6,7,8,3\u2032,4\u2032-Heptamethoxyflavone ameliorates depressive-like behavior and hippocampal neurochemical changes in chronic unpredictable mild stressed mice by regulating the brain-derived neurotrophic factor: requirement for ERK activation. Int. J. Mol. Sci. 18, 2133 (2017). doi: 10.3390\/ijms18102133","DOI":"10.3390\/ijms18102133"},{"key":"63","doi-asserted-by":"publisher","unstructured":"63) Gezen-Ak, D.; Dursun, E.; Hana\u011fas\u0131, H.; Bilgi\u00e7, B.; Lohman, E. et al. BDNF, TNF\u03b1, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer\u2019s disease or mild cognitive impairment. J. Alzheimers Dis. 37, 185-195 (2013). doi: 10.3233\/jad-130497","DOI":"10.3233\/JAD-130497"},{"key":"64","doi-asserted-by":"publisher","unstructured":"64) Karege, F.; Bondolfi, G.; Gervasoni, N.; Schwald, M.; Aubry, J.M. et al. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol. Psychiatry 57, 1068-1072 (2005). doi: 10.1016\/j.biopsych.2005.01.008","DOI":"10.1016\/j.biopsych.2005.01.008"},{"key":"65","doi-asserted-by":"publisher","unstructured":"65) Pl\u00e1ten\u00edk, J.; Fi\u0161ar, Z.; Buchal, R.; Jir\u00e1k, R.; Kitzlerov\u00e1, E. et al. GSK3\u03b2, CREB, and BDNF in peripheral blood of patients with Alzheimer\u2019s disease and depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 50, 83-93 (2014). doi: 10.1016\/j.pnpbp.2013.12.001","DOI":"10.1016\/j.pnpbp.2013.12.001"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Turana, Y.; Ranakusuma, T.A.; Purba, J.S.; Amir, N.; Ahmad, S.A. et al. Enhancing diagnostic accuracy of aMCI in the elderly: combination of olfactory test, pupillary response test, BDNF plasma level, and APOE genotype. Int. J. Alzheimers Dis. 2014, 912586 (2014). doi: 10.1155\/2014\/912586","DOI":"10.1155\/2014\/912586"},{"key":"67","doi-asserted-by":"publisher","unstructured":"67) Weinstein, G.; Beiser, A.S.; Choi, S.H.; Preis, S.R.; Chen, T.C. et al. Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol. 71, 55-61 (2014). doi: 10.1001\/jamaneurol.2013.4781","DOI":"10.1001\/jamaneurol.2013.4781"},{"key":"68","doi-asserted-by":"publisher","unstructured":"68) Jiang, L.; Zhang, H.; Wang, C.; Ming, F.; Shi, X. et al. Serum level of brain-derived neurotrophic factor in Parkinson\u2019s disease: a meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry 88, 168-174 (2019). doi: 10.1016\/j.pnpbp.2018.07.010","DOI":"10.1016\/j.pnpbp.2018.07.010"},{"key":"69","doi-asserted-by":"publisher","unstructured":"69) Jin, W. Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson\u2019s disease. J. Clin. 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