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Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic\/obese KK-A<sup>y<\/sup> mice. J. Food Sci. 77, H114-H120 (2012). doi: 10.1111\/j.1750-3841.2012.02687x","DOI":"10.1111\/j.1750-3841.2012.02687.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Yamashita, M.; Kumazoe, M.; Nakamura, Y.; Won, Y.S.; Bae, J. et al. The combination of green tea extract and eriodictyol inhibited high-fat\/high-sucrose diet-induced cholesterol upregulation is accompanied by suppression of cholesterol synthesis enzymes. J. Nutr. Sci.Vitaminol.  (Tokyo) 62, 249-256 (2016). doi: 10. 3177\/jnsv.62.249","DOI":"10.3177\/jnsv.62.249"},{"key":"38","doi-asserted-by":"publisher","unstructured":"38) Yoshitomi, R.; Yamamoto, M.; Kumazoe, M.; Fujimura, Y.; Yonekura, M. et al. The combined effect of green tea and \u03b1-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial. Sci. 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