{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:20:34Z","timestamp":1781115634493,"version":"3.54.1"},"reference-count":33,"publisher":"Japan Oil Chemists' Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2024]]},"DOI":"10.5650\/jos.ess23167","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T22:14:38Z","timestamp":1714515278000},"page":"695-708","source":"Crossref","is-referenced-by-count":5,"title":["The Regulatory Mechanism of &lt;i&gt;Smilax China&lt;\/i&gt; L. Saponins against Nonalcoholic Fatty Liver Is Revealed by Metabolomics and Transcriptomics"],"prefix":"10.5650","volume":"73","author":[{"given":"Cuiyu","family":"Li","sequence":"first","affiliation":[{"name":"Metabolomics Laboratory, Guangxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Fang","sequence":"additional","affiliation":[{"name":"Metabolomics Laboratory, Guangxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Metabolomics Laboratory, Guangxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou","family":"Mo","sequence":"additional","affiliation":[{"name":"Metabolomics Laboratory, Guangxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lin","sequence":"additional","affiliation":[{"name":"Metabolomics Laboratory, Guangxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanfang","family":"Huang","sequence":"additional","affiliation":[{"name":"The Pharmaceutical Department, Guangxi University of Chinese Medicine First Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Brunt, E.M.; Wong, V.W.; Nobili, V.; Day, C.P.; Sookoian, S. et al. Nonalcoholic fatty liver disease. Nat. Rev. Dis. Primers 1, 15080 (2015). doi.org\/10.1038\/nrdp. 2015.80","DOI":"10.1038\/nrdp.2015.80"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) Neuschwander-Tetri, B.A. Non-alcoholic fatty liver disease. BMC Med. 15, 45 (2017). doi.org\/10.1186\/s12916-017-0806-8","DOI":"10.1186\/s12916-017-0806-8"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Svegliati-Baroni, G.; Pierantonelli, I.; Torquato, P.; Marinelli, R.; Ferreri, C. et al. Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease. Free Radic. Biol. Med. 144, 293-309 (2019). doi.org\/10.1016\/j.freeradbiomed.2019.05.029","DOI":"10.1016\/j.freeradbiomed.2019.05.029"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) Liu, C.; Liao, J.Z.; Li, P.Y. Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. World J. Gastroenterol. 23, 1964-1973 (2017). doi.org\/10.3748\/wjg.v23.i11.1964","DOI":"10.3748\/wjg.v23.i11.1964"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5) Zhao, X.; Chen, R.; Shi, Y.; Zhang, X.; Tian, C. et al. Antioxidant and anti-inflammatory activities of six flavonoids from Smilax glabra Roxb. Molecules 25, 5295 (2020). doi.org\/doi:10.3390\/molecules25225295","DOI":"10.3390\/molecules25225295"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Tu, J.; Deng, L.; Ling, Y.; Zhu, K.; Cai, Y. et al. Transcriptome profiling reveals multiple pathways responsible for the beneficial metabolic effects of Smilax glabra flavonoids in mouse 3T3-L1 adipocytes. Biomed. Pharmacother. 125, 110011 (2020). doi.org\/10.1016\/j.biopha.2020.110011","DOI":"10.1016\/j.biopha.2020.110011"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7) Yang, L.; Zhao, Y.; Pan, Y.; Li, D.; Zheng, G. Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice. Nutr.Metab. 16, 6 (2019). doi.org\/10.1186\/s12986-019-0333-z","DOI":"10.1186\/s12986-019-0333-z"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) Li, X.; Yang, L.; Li, J.; Lin, L.; Zheng, G. A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor\/AMPK signalling pathway and modulating the gut microbiota in mice. Food Funct. 12, 5862-5875 (2021). doi.org\/10.1039\/d1fo00282a","DOI":"10.1039\/D1FO00282A"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) Xu, M.; Xue, H.; Kong, L.; Lin, L.; Zheng, G. Smilax china L. Polyphenols improves insulin resistance and obesity in high-fat diet-induced mice through IRS\/AKT-AMPK and NF-\u03baB signaling pathways. Plant Foods Hum. Nutr. 78, 299-306 (2023). doi.org\/10.1007\/s11130-023-01052-y","DOI":"10.1007\/s11130-023-01052-y"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Chambers, D.C.; Carew, A.M.; Lukowski, S.W.; Powell, J.E. Transcriptomics and single-cell RNA-sequencing. Respirology 24, 29-36 (2019). doi.org\/10.1111\/resp. 13412","DOI":"10.1111\/resp.13412"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11) Zheng, F.; Xia, Z.A.; Zeng, Y.F.; Luo, J.K.; Sun, P. et al. Plasma metabolomics profiles in rats with acute traumatic brain injury. PLoS One 12, e0182025 (2017). doi.org\/10.1371\/journal.pone.0182025","DOI":"10.1371\/journal.pone.0182025"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12) Xie, Y.; Hu, D.; Zhong, C.; Liu, K.F.; Fang, E. et al. Anti-inflammatory furostanol saponins from the rhizomes of Smilax china L. Steroids 140, 70-76 (2018). doi.org\/10.1016\/j.steroids.2018.09.011","DOI":"10.1016\/j.steroids.2018.09.011"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) Feng, Z.; Pang, L.; Chen, S.; Pang, X.; Huang, Y. et al. Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4\/NF-\u03baB and PI3K\/Akt pathways in C57BL\/6J mice. Int. Immunopharmacol. 88, 107003 (2020). doi.org\/10.1016\/j.intimp.2020.107003","DOI":"10.1016\/j.intimp.2020.107003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Long, J.K.; Dai, W.; Zheng, Y.W.; Zhao, S.P. miR-122 promotes hepatic lipogenesis via inhibiting the LKB1\/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease. Mol. Med. 25, 26 (2019). doi.org\/10. 1186\/s10020-019-0085-2","DOI":"10.1186\/s10020-019-0085-2"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15) Xiong, Y.; Wen, S.; Li, Y.; Wei, Y.; Fang, B. et al. Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis. Eur. J. Pharmacol. 919, 174770 (2022). doi.org\/10.1016\/j.ejphar.2022.174770","DOI":"10.1016\/j.ejphar.2022.174770"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16) Choi, J.S.; Koh, I.U.; Song, J. Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats. Nutr. Res. 32, 844-55 (2012). doi.org\/10.1016\/j.nutres.2012.10.002","DOI":"10.1016\/j.nutres.2012.10.002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sztolsztener, K.; Konstantynowicz-Nowicka, K.; Harasim-Symbor, E.; Chabowski, A. Time-dependent changes in hepatic sphingolipid accumulation and PI3K\/Akt\/mTOR signaling pathway in a rat model of NAFLD. Int. J. Mol. Sci. 22, 12478 (2021). doi.org\/10. 3390\/ijms222212478","DOI":"10.3390\/ijms222212478"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18) Kim, S.Q.; Mohallem, R.; Franco, J.; Buhman, K.K.; Kim, K.H. et al. Multi-omics approach reveals dysregulation of protein phosphorylation correlated with lipid metabolism in mouse non-alcoholic fatty liver. Cells 11, (2022). doi.org\/10.3390\/cells11071172","DOI":"10.3390\/cells11071172"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Lackner, K.; Sailer, S.; van Klinken, J.B.; Wever, E.; Pras-Raves, M.L. et al. Alterations in ether lipid metabolism and the consequences for the mouse lipidome. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1868, 159285 (2023). doi.org\/10.1016\/j.bbalip.2023. 159285","DOI":"10.1016\/j.bbalip.2023.159285"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20) Bian, X.; Gao, W.; Wang, Y.; Yao, Z.; Xu, Q. et al. Riboflavin deficiency affects lipid metabolism partly by reducing apolipoprotein B100 synthesis in rats. J. Nutr. Biochem. 70, 75-81 (2019). doi.org\/10.1016\/j.jnutbio.2019.04.011","DOI":"10.1016\/j.jnutbio.2019.04.011"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21) Carro, M.; Buschiazzo, J.; R\u00edos, G.L.; Oresti, G.M.; Alberio, R.H. Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. Theriogenology 79, 687-694 (2013). doi.org\/10.1016\/j.theriogenology.2012.11.025","DOI":"10.1016\/j.theriogenology.2012.11.025"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22) Liu, L.; Liu, X.; Cui, H.; Liu, R.; Zhao, G. et al. Transcriptional insights into key genes and pathways controlling muscle lipid metabolism in broiler chickens. BMC Genomics 20, 863 (2019). doi.org\/10.1186\/s12864-019-6221-0","DOI":"10.1186\/s12864-019-6221-0"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Kitagawa, E.; Yamamoto, T.; Yamamoto, K.; Nakagawa, T.; Hayakawa, T. Accumulation of lipid in rat liver was induced by vitamin B<sub>\u2086<\/sub> deficiency and was ameliorated by supplemental phosphatidylcholine in the diet. Biosci. Biotechnol. Biochem. 79, 1320-1326 (2015). doi.org\/10.1080\/09168451.2015.1020755","DOI":"10.1080\/09168451.2015.1020755"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Shi, L.; Tu, B.P. Acetyl-CoA and the regulation of metabolism: mechanisms and consequences. Curr. Opin. Cell Biol. 33, 125-131 (2015). doi.org\/10.1016\/j.ceb. 2015.02.003","DOI":"10.1016\/j.ceb.2015.02.003"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25) Wardani, H.A.; Rahmadi, M.; Ardianto, C.; Balan, S.S.; Kamaruddin, N.S. et al. Development of nonalcoholic fatty liver disease model by high-fat diet in rats. J. Basic Clin. Physiol. Pharmacol. 30, 20190258 (2019). doi.org\/doi:10.1515\/jbcpp-2019-0258","DOI":"10.1515\/jbcpp-2019-0258"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26) Dickson, I. Full-spectrum transcriptomics in NAFLD. Nat. Rev. Gastroenterol. Hepatol. 18, 82 (2021). doi.org\/10.1038\/s41575-021-00412-w","DOI":"10.1038\/s41575-021-00412-w"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) Hannun, Y.A.; Obeid, L.M. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9, 139-150 (2008). doi.org\/10.1038\/nrm2329","DOI":"10.1038\/nrm2329"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28) Kolter, T. A view on sphingolipids and disease. Chem. Phys. Lipids 164, 590-606 (2011). doi.org\/10.1016\/j.chemphyslip.2011.04.013","DOI":"10.1016\/j.chemphyslip.2011.04.013"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29) Kartsoli, S.; Kostara, C.E.; Tsimihodimos, V.; Bairaktari, E.T.; Christodoulou, D.K. Lipidomics in non-alcoholic fatty liver disease. World J. Hepatol. 12, 436-450 (2020). doi.org\/10.4254\/wjh.v12.i8.436","DOI":"10.4254\/wjh.v12.i8.436"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30) Kitade, H.; Chen, G.; Ni, Y.; Ota, T. Nonalcoholic fatty liver disease and insulin resistance: New insights and potential new treatments. Nutrients 9, 387 (2017). doi.org\/doi:10.3390\/nu9040387","DOI":"10.3390\/nu9040387"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31) Lockman, K.A.; Nyirenda, M.J. Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease. Curr. Diabetes Rev. 6, 341-347 (2010). doi.org\/10.2174\/157339910793360879","DOI":"10.2174\/157339910793360879"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Cai, L.; Tu, B.P. On acetyl-CoA as a gauge of cellular metabolic state. Cold Spring Harb. Symp. Quant. Biol. 76, 195-202 (2011). doi.org\/10.1101\/sqb.2011.76. 010769","DOI":"10.1101\/sqb.2011.76.010769"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33) Ali, A.; Zhang, Y.; Fu, M.; Pei, Y.; Wu, L. et al. Cystathionine gamma-lyase\/H (2) S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice. Life Sci. 252, 117661 (2020). doi.org\/10.1016\/j.lfs.2020.117661","DOI":"10.1016\/j.lfs.2020.117661"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/73\/5\/73_ess23167\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T04:08:40Z","timestamp":1714795720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/73\/5\/73_ess23167\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess23167","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"ess23167"}}