{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:14:27Z","timestamp":1790709267286,"version":"4.1.0"},"reference-count":30,"publisher":"Japan Oil Chemists' Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2024]]},"DOI":"10.5650\/jos.ess24083","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T22:16:07Z","timestamp":1725142567000},"page":"1213-1220","source":"Crossref","is-referenced-by-count":3,"title":["Development of Ampelopsis Radix Ethanolic Extract Loaded Phytosomes for Improved Efficacy in Colorectal Cancer: &lt;i&gt;in vitro&lt;\/i&gt; and &lt;i&gt;in vivo&lt;\/i&gt; Assessment Study"],"prefix":"10.5650","volume":"73","author":[{"given":"Hongze","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Spleen and Stomach Diseases, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Diseases, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[{"name":"Anorectal Department, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Medical Department, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Anorectal Department, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Spleen and Stomach Diseases, Jiujiang Hospital of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueran","family":"Wu","sequence":"additional","affiliation":[{"name":"Chronic Disease Department, Jiujiang Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) M\u00e1rmol, I.; S\u00e1nchez-de-Diego, C.; Pradilla Dieste, A.; Cerrada, E.; Rodriguez Yoldi, M.J. Colorectal carcinoma: A general overview and future perspectives in colorectal cancer. Int. J. Mol. Sci. 18, 197 (2017).","DOI":"10.3390\/ijms18010197"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Stoffel, E.M.; Murphy, C.C. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults. Gastroenterology 158, 341-353 (2020).","DOI":"10.1053\/j.gastro.2019.07.055"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kuipers, E.J.; Grady, W.M.; Lieberman, D.; Seufferlein, T.; Sung, J.J. et al. Colorectal cancer. Nat. Rev. Dis. Primers 1, 1-25 (2015).","DOI":"10.1038\/nrdp.2015.65"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) McQuade, R.M.; Stojanovska, V.C.; Bornstein, J.; Nurgali, K. Colorectal cancer chemotherapy: The evolution of treatment and new approaches. Curr. Med. Chem. 24, 1537-1557 (2017).","DOI":"10.2174\/0929867324666170111152436"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Rinaldi, F.; George, E.; Adler, A.I. NICE guidance on cetuximab, bevacizumab, and panitumumab for treatment of metastatic colorectal cancer after first-line chemotherapy. Lancet Oncol. 13, 233-244 (2012).","DOI":"10.1016\/S1470-2045(12)70044-X"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Haddock, M.G. Intraoperative radiation therapy for colon and rectal cancers: A clinical review. Radiat. Oncol. 12, 1-8 (2017).","DOI":"10.1186\/s13014-016-0752-1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kirchhoff, P.; Clavien, P.A.; Hahnloser, D. Complications in colorectal surgery: Risk factors and preventive strategies. Patient Saf. Surg. 4, 1-3 (2010).","DOI":"10.1186\/1754-9493-4-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Choudhari, A.S.; Mandave, P.C.; Deshpande, M.; Ranjekar, P.; Prakash, O. Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Front. Pharmacol. 10, 1614 (2020).","DOI":"10.3389\/fphar.2019.01614"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Esmeeta, A.; Adhikary, S.; Dharshnaa, V.; Swarnamughi, P.; Maqsummiya, Z.U. et al. Plant-derived bioactive compounds in colon cancer treatment: An updated review. Biomed. Pharmacother. 153, 113384 (2022).","DOI":"10.1016\/j.biopha.2022.113384"},{"key":"10","unstructured":"10) Tao, S.; Xinning, W.; Chunyu, L.; Jingxuan, B.; Cheng, C.Y. et al. An ethanolic extract of Bailian (Radix Ampelopsis japonicae) : Demonstration of colorectal cancer treatment efficacy via inhibition of \u03b2-catenin signaling in vitro. J. Tradit. Chin. Med. 39, 339 (2019)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tian, C.; Huang, H.; He, X.; Yan, L.; Shi, L. et al. Identification of an effective fraction from Ampelopsis Radix with anti-dengue virus activities in vitro and in vivo. J. Ethnopharmacol. 309, 116339 (2023).","DOI":"10.1016\/j.jep.2023.116339"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Su, T.; Bai, J.X.; Chen, Y.J.; Wang, X.N.; Fu, X.Q. et al. An ethanolic extract of Ampelopsis Radix exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling in vitro. Front. Pharmacol. 8, 227 (2017).","DOI":"10.3389\/fphar.2017.00227"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Barani, M.; Sangiovanni, E.; Angarano, M.; Rajizadeh, M.A.; Mehrabani, M. et al. Phytosomes as innovative delivery systems for phytochemicals: A comprehensive review of literature. Int. J. Nanomedicine 16, 6983-7022 (2021).","DOI":"10.2147\/IJN.S318416"},{"key":"14","unstructured":"14) Bhise, J.J.; Bhusnure, O.G.; Jagtap, S.R.; Gholve, S.B.; Wale, R.R. Phytosomes: A novel drug delivery for herbal extracts. J. Drug Deliv. Ther. 9, 924-930 (2019)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Rathee, S.; Kamboj, A. Optimization and development of antidiabetic phytosomes by the Box\u2013Behnken design. J. Liposome Res. 28, 161-172 (2018).","DOI":"10.1080\/08982104.2017.1311913"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Sabzichi, M.; Hamishehkar, H.; Ramezani, F.; Sharifi, S.; Tabasinezhad, M. et al. Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. Asian Pac. J. Cancer Prev. 15, 5311-5316 (2014).","DOI":"10.7314\/APJCP.2014.15.13.5311"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Hou, Z.; Li, Y.; Huang, Y.; Zhou, C.; Lin, J. et al. Phytosomes loaded with mitomycin C\u2013soybean phosphatidylcholine complex developed for drug delivery. Mol. Pharm. 10, 90-101 (2013).","DOI":"10.1021\/mp300489p"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Zhang, R.; Qin, X.; Kong, F.; Chen, P.; Pan, G. Improving cellular uptake of therapeutic entities through interaction with components of cell membrane. Drug Deliv. 26, 328-342 (2019).","DOI":"10.1080\/10717544.2019.1582730"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Murugesan, M.P.; Ratnam, M.V.; Mengitsu, Y.; Kandasamy, K. Evaluation of anti-cancer activity of phytosomes formulated from aloe vera extract. Mater. Today Proc. 42, 631-636 (2012).","DOI":"10.1016\/j.matpr.2020.11.047"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Maryana, W.; Rachmawati, H.; Mudhakir, D. Formation of phytosome containing silymarin using thin layer-hydration technique aimed for oral delivery. Mater. Today Proc. 3, 855-866 (2016).","DOI":"10.1016\/j.matpr.2016.02.019"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Das, M.K.; Kalita, B. Design and evaluation of phyto-phospholipid complexes (phytosomes) of rutin for transdermal application. J. Appl. Pharm. Sci. 4, 051-057 (2014).","DOI":"10.7324\/JAPS.2014.401010"},{"key":"22","unstructured":"22) Nimbalkar, C.K.; Hatware, K. Phytosomes-novel drug delivery system. IJOD 5, 16-36 (2017)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Waghule, T.; Saha, R.N.; Alexander, A.; Singhvi, G. Tailoring the multi-functional properties of phospholipids for simple to complex self-assemblies. J. Control. Release 349, 460-474 (2022).","DOI":"10.1016\/j.jconrel.2022.07.014"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Mahmoud, K.; Swidan, S.; El-Nabarawi, M.; Teaima, M. Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: A comprehensive review on targeting and recent advances. J. Nanobiotechnology 20, 109 (2022).","DOI":"10.1186\/s12951-022-01309-9"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Dutt, Y.; Pandey, R.P.; Dutt, M.; Gupta, A.; Vibhuti, A. et al. Liposomes and phytosomes: Nanocarrier systems and their applications for the delivery of phytoconstituents. Coord. Chem. Rev. 491, 215251 (2023).","DOI":"10.1016\/j.ccr.2023.215251"},{"key":"26","unstructured":"26) Patel, J.; Patel, R.; Khambholja, K.; Patel, N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J. Pharm. Sci. 4, 363-371 (2009)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Wong, K.E.; Ngai, S.C.; Chan, K.G.; Lee, L.H.; Goh, B.H. et al. Curcumin nano formulations for colorectal cancer: A review. Front. Pharmacol. 10, 152 (2019).","DOI":"10.3389\/fphar.2019.00152"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Esfanjani, A.F.; Assadpour, E.; Jafari, S.M. Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers. Trends Food Sci. Technol. 76, 56-66 (2018).","DOI":"10.1016\/j.tifs.2018.04.002"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Mosquera, J.; Garc\u00eda, I.; Liz-Marz\u00e1n, L.M. Cellular uptake of nanoparticles versus small molecules: A matter of size. Acc Chem. Res. 51, 2305-2313 (2018).","DOI":"10.1021\/acs.accounts.8b00292"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Li, Y.; Lin, J.; Liu, G.; Li, Y.; Song, L. et al. Self-assembly of multifunctional integrated nanoparticles loaded with a methotrexate\u2013phospholipid complex: Combining simplicity and efficacy in both targeting and anticancer effects. RSC Adv. 6, 86717-8627 (2016).","DOI":"10.1039\/C6RA17260A"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/73\/9\/73_ess24083\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T04:16:11Z","timestamp":1725682571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/73\/9\/73_ess24083\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess24083","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"ess24083"}}