{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:11:26Z","timestamp":1781770286383,"version":"3.54.5"},"reference-count":51,"publisher":"Japan Oil Chemists' Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2025]]},"DOI":"10.5650\/jos.ess24228","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T22:15:52Z","timestamp":1735683352000},"page":"79-88","source":"Crossref","is-referenced-by-count":6,"title":["In vitro Antioxidant and Antibacterial Activities, Bioactive Compounds, Organic Acids, Sugars, Micro- and Macro-elements of &lt;i&gt;Aquilaria agallocha&lt;\/i&gt; Root Organic Extracts"],"prefix":"10.5650","volume":"74","author":[{"given":"Hatice Feyza","family":"Akbulut","sequence":"first","affiliation":[{"name":"\u00c7umra Vocational School, Department of Medicinal and Aromatic Plants, Selcuk University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3621","reference":[{"key":"1","unstructured":"1) Nguyen, L.T.; Chang, Y.S.; Kadir, A.A. A Review on agar (Gaharu) producing Aquilaria species. J. Trop. For. Sci. 2, 272-285 (1997)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Wang, S.; Yu, Z.; Wang, C.; Wu, C.; Guo, P.; Wei, J. Chemical constituents and pharmacological activity of agarwood and Aquilaria plants. Molecules 23, 342 (2018).","DOI":"10.3390\/molecules23020342"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kalra, R.; Kaushik, N.A. Review of chemistry, quality and analysis of infected agarwood tree (Aquilaria sp.). Phytochem. Rev. 16, 1045-1079 (2017).","DOI":"10.1007\/s11101-017-9518-0"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Abbasi, A.M.; Khan, M.A.; Ahmad, M.; Jahan, S.; Sultana, S. Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan. J. Ethnopharmocol. 128, 322-335 (2010).","DOI":"10.1016\/j.jep.2010.01.052"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Canli, K.; Yetgin, A.; Akata, I.; Altuner, E.M. In vitro antimicrobial screening of Aquilaria agallocha roots. Afr. J. Tradit. Complement. Altern. Med. 13, 178-181 (2016).","DOI":"10.21010\/ajtcam.v13i5.23"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Alam, J.; Mujahid, M.; Rahman, M.A.; Akhtar, J.; Khalid, M.; Jahan, Y. et al. An insight of pharmacognostic study and phytopharmacology of Aquilaria agallocha. J. Appl. Pharm. Sci. 5, 173-181 (2015).","DOI":"10.7324\/JAPS.2015.50827"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Li, W.; Chen, H.Q.; Wang, H.; Mei, W.L.; Dai, H.F. Natural products in agarwood and Aquilaria plants: chemistry, biological activities and biosynthesis. Nat. Prod. Rep. 38, 528-565 (2021).","DOI":"10.1039\/D0NP00042F"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kristanti, A.N.; Tanjung, M.; Aminah, N.S. Secondary metabolites of Aquilaria, a Thymelaeaceae genus. Mini-Rev. Org. Chem. 15, 36-55 (2018).","DOI":"10.2174\/1570193X14666170721143041"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yuan, H.W.; Zhao, J.P.; Liu, Y.B.; Qiu, Y.X.; Xie, Q.L.; Li, M.J.; Khan, I.A.; Wang, W. Advance in studies on chemical constituents, pharmacology and quality control of Aquilaria sinensis. Digital Chinese Medicine 1, 316-330 (2018).","DOI":"10.1016\/S2589-3777(19)30057-6"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Shivanand, P.; Arbie, N.F.; Krishnamoorthy, S.; Ahmad, N. Agarwood\u2014the fragrant molecules of a wounded tree. Molecules 27, 3386 (2022).","DOI":"10.3390\/molecules27113386"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tan, C.S.; Isa, N.M.; Ismail, I.; Zainal, Z. Agarwood induction: current developments and future perspectives. Front. Plant Sci. 10, 122 (2019).","DOI":"10.3389\/fpls.2019.00122"},{"key":"12","unstructured":"12) Thu, M.M.; Mon, K.H.; Aye, H.H.; Ngwe, D.H. Investigation of phytoconstituents and some bioactivities of leaves and barks of Aquilaria agallocha roxb. (Thit-Mhwae). Journal of the Myanmar Academy of Arts and Science 16, 333-348 (2018)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Singleton, V.L.; Rossi, J.A. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 16, 144-158 (1965).","DOI":"10.5344\/ajev.1965.16.3.144"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Akbulut, H.F.; Akbulut, M. Mineral composition, the profile of phenolic compounds, organic acids, sugar and in vitro antioxidant capacity, and antimicrobial activity of organic extracts of Juniperus drupacea fruits. Food Sci. Nutr. 11, 6435-6446 (2023).","DOI":"10.1002\/fsn3.3586"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Coklar, H.; Akbulut, M. Anthocyanins and phenolic compounds of Mahonia aquifolium berries and their contributions to antioxidant activity. J. Funct. Foods 35, 166-174 (2017).","DOI":"10.1016\/j.jff.2017.05.037"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Coklar, H.; Akbulut, M.; Alhassan, I.; Kirpitci, \u015e.; Korkmaz, E. Organic acids, sugars, phenolic compounds and antioxidant activity of Malus floribunda coccinella fruit, peel and flesh. Hortorum Cultus Acta Sci. Pol. Hortorum Cultus 17, 47-59 (2018).","DOI":"10.24326\/asphc.2018.5.5"},{"key":"17","unstructured":"17) Skujins, S. Handbook for ICP-AES (varian-vista) A short guide to vista series ICP-AES operation. Varian Int. AG. Zug. Version, 1.0 (1998)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Brand-Williams, W.; Cuvelier, M.-E.; Berset, C. Use of a free radical method to evaluate antioxidant activity. LWT-Food Sci. Technol. 28, 25-30 (1995).","DOI":"10.1016\/S0023-6438(95)80008-5"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Senhaji, S.; Lamchouri, F.; Toufik, H. Phytochemical content, antibacterial and antioxidant potential of endemic plant Anabasis aretio\u00efdes Coss. &amp; Moq. (Chenopodiaceae). Biomed Res. Int. 6152932 (2020).","DOI":"10.1155\/2020\/6152932"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Mostafa, A.A.; Al-Askar, A.A.; Almaary, K.S.; Dawoud, T.M.; Sholkamy, E.N.; Bakri, M.M. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi J. Biol. Sci. 25, 361-366 (2018).","DOI":"10.1016\/j.sjbs.2017.02.004"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) \u0130spirli, H.; Demirba\u015f, F.; Dertli, E. Characterization of functional properties of Enterococcus spp. isolated from Turkish white cheese. LWT-Food Sci. Technol. 75, 358-365 (2017).","DOI":"10.1016\/j.lwt.2016.09.010"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Dhiman, R.; Aggarwal, N.K.; Aneja, K.R.; Kaur, M. In vitro antimicrobial activity and phytochemical studies of Terminalia chebula against the microbes isolated from fruit juices. J. Microbiol. Biotechnol. Food Sci. 2021, 243-247 (2021).","DOI":"10.15414\/jmbfs.2015\/16.5.3.243-247"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) \u00d6zkan, E.R.; Demirci, T.; Ak\u0131n, N. In vitro assessment of probiotic and virulence potential of Enterococcus faecium strains derived from artisanal goatskin casing Tulum cheeses produced in central Taurus Mountains of Turkey. LWT-Food Sci. Technol. 141, 110908 (2021).","DOI":"10.1016\/j.lwt.2021.110908"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Ingenbleek, Y.; Kimura, H. Nutritional essentiality of sulfur in health and disease. Nutr. Rev. 71, 413-432 (2013).","DOI":"10.1111\/nure.12050"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) McLaughlin, M.J.; Parker, D.R.; Clarke, J.M. Metals and micronutrients\u2013food safety issues. Field Crops Res. 60, 143-163 (1999).","DOI":"10.1016\/S0378-4290(98)00137-3"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Choi, M.K.; Bae, Y.J. Dietary intake and urinary excretion of manganese in Korean healthy adults. Biol. Trace Elem. Res. 196, 384-392 (2020).","DOI":"10.1007\/s12011-019-01932-y"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Devirian, T.A.; Volpe, S.L. The physiological effects of dietary boron. Crit. Rev. Food Sci. Nutr. 43, 219-231 (2003).","DOI":"10.1080\/10408690390826491"},{"key":"28","unstructured":"28) Vaghela, S.S.; Jethva, A.D.; Gohil, M.S. Cyclic voltametric and galvanostatic electrolysis studies on the reduction of maleic acid in buffered and unbuffered solutions. Bull. Electrochem. 18, 237-240 (2002)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Saxena, R.K.; Saran, S.; Isar, J.; Kaushik, R. Production and applications of succinic acid. in Current developments in biotechnology and bioengineering. Elsevier, pp. 601-630 (2017).","DOI":"10.1016\/B978-0-444-63662-1.00027-0"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kader, A.A. Flavor quality of fruits and vegetables. J. Sci. Food Agric. 88, 1863-1868 (2008).","DOI":"10.1002\/jsfa.3293"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Perkins-Veazie, P.; Collins, J.K. Contributions of nonvolatile phytochemicals to nutrition and flavor. HortTechnology 11, 539-546 (2001).","DOI":"10.21273\/HORTTECH.11.4.539"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Akbulut, H.F.; Almaghrebi, E.; Obali, I.; Vatansev, H.; Vatansev, H.; Akbulut, M. Evaluation the organic acid, tocopherol and phenolic profiles of Dracaena cinnabari resin extracts obtained by different solvent extraction. Lat. Am. Appl. Res. 54, 195-200 (2024).","DOI":"10.52292\/j.laar.2024.2865"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Nahar, J.; Boopathi, V.; Rupa, E.J.; Awais, M.; Valappil, A.K. et al. Protective effects of Aquilaria agallocha and Aquilaria malaccensis edible plant extracts against lung cancer, inflammation, and oxidative stress\u2014in silico and in vitro study. Appl. Sci. 13, 6321 (2023).","DOI":"10.3390\/app13106321"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Hashim, Y.Z.H.Y.; Kerr, P.G.; Abbas, P.; Salleh, H.M. Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology. J. Ethnopharmacol. 189, 331-360 (2016).","DOI":"10.1016\/j.jep.2016.06.055"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Bahrani, H.; Mohamad, J.; Paydar, M.; Rothan, H.A. Isolation and characterisation of acetylcholinesterase inhibitors from Aquilaria subintegra for the treatment of Alzheimer\u2019s disease (AD). Curr. Alzheimer Res. 11, 1-9 (2014).","DOI":"10.2174\/1567205011666140130151344"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Ruddock, P.L.; Facey, P. Tannins. in Pharmacognosy. Academic Press, pp. 211-251 (2024).","DOI":"10.1016\/B978-0-443-18657-8.00015-3"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) G\u00fcl\u00e7in, \u0130.; Huyut, Z.; Elmasta\u015f, M.; Aboul-Enein, H.Y. Radical scavenging and antioxidant activity of tannic acid. Arab. J. Chem. 3, 43-53 (2010).","DOI":"10.1016\/j.arabjc.2009.12.008"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Kaczmarek, B.; Nadolna, K.; Owczarek, A.; Michalska-Sionkowska, M.; Sionkowska, A. The characterization of thin films based on chitosan and tannic acid mixture for potential applications as wound dressings. Polym. Test. 78, 106007 (2019).","DOI":"10.1016\/j.polymertesting.2019.106007"},{"key":"39","unstructured":"39) Vakati, K.; Rahman, H.; Eswaraiah, M.C.; Dutta, A.M. Evaluation of hepatoprotective activity of ethanolic extract of Aquilaria agallocha leaves (EEAA) against CCl4 induced hepatic damage in rat. Sch. J. Appl. Med. Sci. 1, 9-12 (2013)."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Kamonwannasit, S.; Nantapong, N.; Kumkrai, P.; Luecha, P.; Kupittayanant, S.; Chudapongse, N. Antibacterial activity of Aquilaria crassna leaf extract against Staphylococcus epidermidis by disruption of cell wall. Ann. Clin. Microbiol. Antimicrob. 12, 1-7 (2013).","DOI":"10.1186\/1476-0711-12-20"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Omar, S.H. Oleuropein in olive and its pharmacological effects. Sci. Pharm. 78, 133-154 (2010).","DOI":"10.3797\/scipharm.0912-18"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Yoon, S.K. Oleuropein as an antioxidant and liver protect. in The Liver. Elsevier, pp 323-335 (2018).","DOI":"10.1016\/B978-0-12-803951-9.00027-6"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Ahamad, J.; Toufeeq, I.; Khan, M.A.; Ameen, M.S.M.; Anwer, E.T. et al. Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome. Phytother. Res. 33, 3112-3128 (2019).","DOI":"10.1002\/ptr.6511"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Bulotta, S.; Corradino, R.; Celano, M.; Maiuolo, J.; D\u2019Agostino, M. et al. Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells. J. Mol. Endocrinol. 51, 181-189 (2013).","DOI":"10.1530\/JME-12-0241"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Al-Azzawie, H.F.; Alhamdani, M.S.S. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 78, 1371-1377 (2006).","DOI":"10.1016\/j.lfs.2005.07.029"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Sattayasai, J.; Bantadkit, J.; Aromdee, C.; Lattmann, E.; Airarat, W. Antipyretic, analgesic and anti-oxidative activities of Aquilaria crassna leaves extract in rodents. J. Ayurveda Integr. Med. 3 (4), 175 (2012).","DOI":"10.4103\/0975-9476.104427"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Miniyar, P.B.; Chitre, T.S.; Deuskar, H.J.; Karve, S.S.; Jain, K.S. Antioxidant activity of ethyl acetate extract of Aquilaria agallocha on nitrite-induced methaemoglobin formation. Int. J. Green Pharm. 2, 116-117 (2008).","DOI":"10.4103\/0973-8258.41185"},{"key":"48","unstructured":"48) Manasi Dash, M.D.; Patra, J.K.; Panda, P.P. Phytochemical and antimicrobial screening of extracts of Aquilaria agallocha Roxb. Afr. J. Biotechnol. 7, 3531-3534 (2008)."},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Cowan, M.M. Plant products as antimicrobial agents. Clin. Microbiol. Rev. 12, 564-582 (1999).","DOI":"10.1128\/CMR.12.4.564"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Miceli, M.H.; D\u00edaz, J.A.; Lee, S.A. Emerging opportunistic yeast infections. Lancet Infect. Dis. 11, 142-151 (2011).","DOI":"10.1016\/S1473-3099(10)70218-8"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Vattem, D.A.; Lin, Y.T.; Labbe, R.G.; Shetty, K. Phenolic antioxidant mobilization in cranberry pomace by solid-state bioprocessing using food grade fungus Lentinus edodes and effect on antimicrobial activity against select food borne pathogens. Innov. Food Sci. Emerg. Technol. 5, 81-91 (2004).","DOI":"10.1016\/j.ifset.2003.09.002"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/74\/1\/74_ess24228\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T04:03:40Z","timestamp":1735963420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/74\/1\/74_ess24228\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess24228","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"ess24228"}}