{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:26:34Z","timestamp":1777728394908,"version":"3.51.4"},"reference-count":26,"publisher":"Japan Oil Chemists' Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2025]]},"DOI":"10.5650\/jos.ess25040","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T22:11:23Z","timestamp":1748729483000},"page":"495-501","source":"Crossref","is-referenced-by-count":1,"title":["Anti-inflammatory Function of Ozonated Ethyl Ester of Unsaturated Fatty Acids"],"prefix":"10.5650","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8842-2680","authenticated-orcid":false,"given":"Yasunari","family":"Kato","sequence":"first","affiliation":[{"name":"Tsukishima Foods Industry Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Manabe","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Biological Resource Science, Saga University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Biological Resource Science, Saga University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Nagai","sequence":"additional","affiliation":[{"name":"School of Bioscience and Biotechnology, Tokyo University of Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1203-5521","authenticated-orcid":false,"given":"Tatsuya","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, Kyoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) G\u00fczel-Seydim, Z.; Bever, P.I.; Greene, A.K. Efficacy of ozone to reduce bacterial populations in the presence of food components. Food Microbiol. 21, 475-479 (2004).","DOI":"10.1016\/j.fm.2003.10.001"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Guzel-Seydim, Z.B.; Greene, A.K.; Seydim, A.C. Use of ozone in the food industry. LWT - Food Sci Technol. 37, 453-460 (2004).","DOI":"10.1016\/j.lwt.2003.10.014"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Concha-Meyer, A.; Eifert, J.D.; Williams, R.C.; Marcy, J.E.; Welbaum, G.E. Shelf life determination of fresh blueberries (Vaccinium corymbosum) stored under controlled atmosphere and ozone. Int. J. Food Sci. 2015, 164143 (2015). doi: 10.1155\/2015\/164143","DOI":"10.1155\/2015\/164143"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Matsumoto, A.; Sakurai, S.; Shinriki, N.; Suzuki, S.; Miura, T. Therapeutic effects of ozonated olive oil in the treatment of intractable fistula and wound after surgical operation. Nihon Rinsho Geka Gakkai Zasshi 61, 1383-1389 (2000).","DOI":"10.3919\/jjsa.61.1383"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Sechi, L.A.; Lezcano, I.; Nunez, N.; Espim, M.; Dupr\u00e8, I. et al. Antibacterial activity of ozonated sunflower oil (Oleozon). J. Appl. Microbiol. 90, 279-284 (2001).","DOI":"10.1046\/j.1365-2672.2001.01235.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Sakazaki, F.; Kataoka, H.; Okuno, T.; Ueno, H.; Semma, M. et al. Ozonated olive oil enhances the growth of granulation tissue in a mouse model of pressure ulcer. Ozone Sci. Eng. 29, 503-507 (2007).","DOI":"10.1080\/01919510701618205"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) G\u00fcltekin, F.A.; Bakkal, B.H.; S\u00fcmer, D.; K\u00f6kt\u00fcrk, F.; Bekta\u015f, S. Effects of ozonated olive oil on acute radiation proctitis in rats. Balkan Med. J. 30, 369-374 (2013).","DOI":"10.5152\/balkanmedj.2013.9158"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Guerra-Blanco, P.; Poznyak, T.; P\u00e9rez, A.; G\u00f3mez y G\u00f3mez, Y.M.; Bautista-Ram\u00edrez, M.E.; Chairez, I. Ozonation degree of vegetable oils as the factor of their anti-inflammatory and wound-healing effectiveness. Ozone Sci. Eng. 39, 374-384 (2017).","DOI":"10.1080\/01919512.2017.1335185"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) Kato, Y.; Sakoh, M.; Nagai, T.; Yoshida, A.; Ishida, H.; Inoue, N.; Nagao, K. et al. Ozonated olive oil alleviates hepatic steatosis in obese Zucker (fa\/fa) rats. J. Oleo Sci. 71, 599-607 (2022). doi:10.5650\/jos.ess21377","DOI":"10.5650\/jos.ess21377"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10) Kato, Y.; Sakoh, M.; Nagai, T.; Yoshida, A.; Ishida, H.; Inoue, N.; Yanagita, T.; Nagao, K. Ozonated olive oil intake attenuates hepatic steatosis in obese db\/db mice. J. Oleo Sci. 73, 231-237 (2024). doi:10.5650\/jos.ess23193. PMID: 38311412","DOI":"10.5650\/jos.ess23193"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Criegee, R. Mechanism of ozonolysis. Angew. Chem. Int. Ed. Engl. 14, 745-752 (1975). doi:10.1002\/anie.197507451","DOI":"10.1002\/anie.197507451"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Boskou, D.; Blekas, G.; Tsimidou, M. Olive oil composition. in Olive Oil. 2nd (Boskou, D. ed.). AOCS press, pp. 41-72 (2006).","DOI":"10.4324\/9781003040217"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) Kato, Y.; Odanaka, Y.; Nagai, T. Analysis of ozonolysis products of ethyl linoleate reacted in dichloromethane solution. Ozone: Sci. Eng. 47, 1-14 (2024). doi:10.1080\/01919512.2024.2396142","DOI":"10.1080\/01919512.2024.2396142"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14) Bertuccio, M.P.; Rizzo, V.; Arena, S.; Trainito, A.; Montalto, A.S. et al. Ozoile reduces the LPS-induced inflammatory response in colonic epithelial cells and THP-1 monocytes. Curr. Issues Mol. Biol. 45, 1333-1348 (2023). doi:10.3390\/cimb45020087","DOI":"10.3390\/cimb45020087"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ma, Q. Role of Nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 53, 401-426 (2013).","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16) Korhonen, R.; Lahti, A.; Kankaanranta, H.; Moilanen, E. Nitric oxide production and signaling in inflammation. Curr. Drug Targets Inflamm. Allergy 4, 471-479 (2005). doi:10.2174\/1568010054526359","DOI":"10.2174\/1568010054526359"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Serasanambati, M.; Chilakapati, S.R. Function of nuclear factor kappa B (NF-\u03baBNF-\u03baB) in human diseases-a review. South Indian J. Biol. Sci. 2, 368-387 (2016).","DOI":"10.22205\/sijbs\/2016\/v2\/i4\/103443"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18) Miller, S.; Ernst, R.; Bader, M. LPS, TLR4 and infectious disease diversity. Nat. Rev. Microbiol. 3, 36-46 (2005). doi:10.1038\/nrmicro1068.","DOI":"10.1038\/nrmicro1068"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kang, J.X.; Weylandt, K.H. Modulation of inflammatory cytokines by omega-3 fatty acids. Lipids Health Dis. 7, 133-143 (2008).","DOI":"10.1007\/978-1-4020-8831-5_5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Tonelli, C.; Chio, I.C.I.; Tuveson, D.A. Transcriptional regulation by Nrf2. Antioxid. Redox Signal. 29, 1727-1745 (2018).","DOI":"10.1089\/ars.2017.7342"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Calder, P.C. Omega-3 fatty acids and inflammatory processes: From molecules to man. Biochem. Soc. Trans. 45, 1105-1115 (2017).","DOI":"10.1042\/BST20160474"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22) Morse, D.; Choi, A.M. Heme oxygenase-1: The \u201cemerging molecule\u201d has arrived. Am. J. Respir. Cell Mol. Biol. 27, 8-16 (2002). doi:10.1165\/ajrcmb.27.1.4862","DOI":"10.1165\/ajrcmb.27.1.4862"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Lee, T.; Tsai, H.; Chau, L. Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. J. Biol. Chem. 278, 19325-19330 (2003). doi:10.1074\/jbc.M300498200.","DOI":"10.1074\/jbc.M300498200"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24) Reynolds, J.C.; Last, D.J.; McGillen, M.; Nijs, A.; Horn, A.B. et al. Structural analysis of oligomeric molecules formed from the reaction products of oleic acid ozonolysis. Environ. Sci. Technol. 40, 6674-6681 (2006). doi:10.1021\/es060942p","DOI":"10.1021\/es060942p"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Shangari, N.; O\u2019Brien, P.J. The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem. Pharmacol. 68, 1433-1442 (2004).","DOI":"10.1016\/j.bcp.2004.06.013"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Riahi, Y.; Cohen, G.; Shamni, O.; Sasson, S. Signaling and cytotoxic functions of 4-hydroxyalkenals. Am. J. Physiol. Endocrinol. Metab. 299, E879-E886 (2010).","DOI":"10.1152\/ajpendo.00508.2010"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/74\/6\/74_ess25040\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T03:48:03Z","timestamp":1749268083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/74\/6\/74_ess25040\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess25040","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"ess25040"}}