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Study on morphological and genetic diversity of Rehmannia glutinosa cultivated in Japan. J. Nat. Med. 76, 352-366 (2022).","DOI":"10.1007\/s11418-021-01587-x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kitagawa, I.; Hori, K.; Kawanishi, T.; Kobayashi, M.; Kawanishi, F. On the constituents of the root of Fukuchiyama-jio, the hybrid of Rehmannia glutinosa var. purpurea and R. glutinosa forma hueichingensis. Yakugaku Zasshi. 118, 464-475 (1998).","DOI":"10.1248\/yakushi1947.118.10_464"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kitagawa, I.; Fukuda, Y.; Taniyama, T.; Yoshikawa, M. Absolute stereostructures of rehmaglutins A, B, and D three new iridoids isolated from Chinese Rehmanniae Radix. Chem. Pharm. Bull. 34, 1399-1402 (1986).","DOI":"10.1248\/cpb.34.1399"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Tomoda, M.; Kato, S.; Onuma, M. Water-soluble constituents of Rehmanniae Radix. I. Carbohydrates and acids of Rehmannia glutinosa f. hueichingensis. Chem. Pharm. Bull. 19, 1455-1460 (1971).","DOI":"10.1248\/cpb.19.1455"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Sasaki, H.; Nishimura, H.; Chin, M.; Chen, Z.; Mitsuhashi, H. Hydroxycinnamic acid esters of phenethyl alcohol glycosides from Rehmannia glutinosa var. purpurea. Phytochemistry 28, 875-879 (1989).","DOI":"10.1016\/0031-9422(89)80134-7"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Morota, T.; Sasaki, H.; Nishimura, H.; Sugama, K.; Chin, M.; Mitsuhashi, H. Two iridoid glycosides from Rehmannia glutinosa. Phytochemistry. 28, 2149-2153 (1989).","DOI":"10.1016\/S0031-9422(00)97934-2"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Zhang, R.-X.; Li, M.-X.; Jia, Z.-P. Rehmannia glutinosa: Review of botany, chemistry and pharmacology. J. Ethnopharmacol. 117, 199-214 (2008).","DOI":"10.1016\/j.jep.2008.02.018"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Takara, K.; Horibe, S.; Obata, Y.; Yoshikawa, E.; Ohnishi, N.; Yokoyama, T. Effects of 19 herbal extracts on the sensitivity to paclitaxel or 5-fluorouracil in HeLa cells. Biol. Pharm. Bull. 28, 138-142 (2005).","DOI":"10.1248\/bpb.28.138"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Li, W.; Wu, H.; Gao, C.; Yang, D.; Yang, D.; Shen, J. Radix Rehmanniae extract ameliorates experimental autoimmune encephalomyelitis by suppressing macrophage-derived nitrative damage. Front. Physiol. 9, 864 (2018).","DOI":"10.3389\/fphys.2018.00864"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Zhou, X.-D.; Shi, D.-D.; Zhang, Z.-J. Ameliorative effects of Radix Rehmanniae extract on the anxiety- and depression-like symptoms in ovariectomized mice: A behavioral and molecular study. Phytomedicine 63, 153012 (2019).","DOI":"10.1016\/j.phymed.2019.153012"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Hao, R.-J.; Hu, Y.-C.; Wei, Y.-Y.; Qin, X.-D.; Lu, Y.-W. The neuroprotective effects of Rehmanniae Radix Praeparata exerts via regulating SKN-1 mediated antioxidant system in Caenorhabditis elegans and activating Nrf2-ARE pathway in vitro. J. Funct. Foods. 113, 106040 (2024).","DOI":"10.1016\/j.jff.2024.106040"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Liu, Y.; Zhu, R.; Liu, B.; Wang, W.; Yang, P. et al. Antidiabetic effect of Rehmanniae Radix based on regulation of TRPV1 and SCD1. Front. Pharmacol. 13, 875014 (2022).","DOI":"10.3389\/fphar.2022.875014"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kubo, M.; Asano, T.; Matsuda, H.; Yutani, S.; Honda, S. Studies on Rehmanniae Radix. III. The relation between changes of constituents and improvable effects on hemorheology with the processing of roots of Rehmannia glutinosa. Yakugaku Zasshi. 116, 158-168 (1996).","DOI":"10.1248\/yakushi1947.116.2_158"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Chao, C.H.; Hsu, J.L.; Chen, M.F.; Shih, Y.H.; Lee, C.H. et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat. Prod. Res. 34, 1547-1552 (2020).","DOI":"10.1080\/14786419.2018.1516660"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Shi, G.R.; Zhou, J.; Wang, X.; Chen, R.Y.; Liu, Y.F.; Yu, D.Q. Three new pyridine alkaloids and one new iridoid analogue from the leaves of Rehmannia glutinosa. J. Asian Nat. Prod. Res. 24, 945-954 (2022).","DOI":"10.1080\/10286020.2022.2102974"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Zhang, Y.L.; Feng, W.S.; Zheng, X.K.; Cao, Y.G.; Lv, Y.Y. et al. Three new ursane-type triterpenes from the leaves of Rehmannia glutinosa. Fitoterapia 89, 15-19 (2013).","DOI":"10.1016\/j.fitote.2013.05.013"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Dai, X.; Su, S.; Cai, H.; Wei, D.; Yan, H. et al. Protective effects of total glycoside from Rehmannia glutinosa leaves on diabetic nephropathy rats via regulating the metabolic profiling and modulating the TGF-\u03b21 and Wnt\/\u03b2-catenin signaling pathway. Front. Pharmacol. 9, 1012 (2018).","DOI":"10.3389\/fphar.2018.01012"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Liguori, I.; Russo, G.; Curcio, F.; Bulli, G.; Aran, L. et al. Oxidative stress, aging, and diseases. Clin. Interv. Aging. 13, 757-772 (2018).","DOI":"10.2147\/CIA.S158513"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Sharifi-Rad, M.; Anil Kumar, N.V.; Zucca, P.; Varoni, E.M.; Dini, L. et al. Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases. Front. Physiol. 11, 694 (2020).","DOI":"10.3389\/fphys.2020.00694"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Bibi Sadeer, N.B.; Montesano, D.; Albrizio, S.; Zengin, G.; Mahomoodally, M.F. The versatility of antioxidant assays in food science and safety-chemistry, applications, strengths, and limitations. Antioxidants (Basel) 9, 709 (2020).","DOI":"10.3390\/antiox9080709"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Apak, R.; \u00d6zy\u00fcrek, M.; G\u00fc\u00e7l\u00fc, K.; \u00c7apano\u011flu, E. Antioxidant activity\/capacity measurement. 1. Classification, physicochemical principles, mechanisms, and electron transfer (ET) -based assays. J. Agric. Food Chem. 64, 997-1027 (2016).","DOI":"10.1021\/acs.jafc.5b04739"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kondo, T.; Uehashi, T.; Watanabe, T.; Kawano, A.; Kurogi, K. et al. Evaluation of multiple antioxidant activities in food components. Nippon Shokuhin Kagaku Kogaku Kaishi 64, 457-463 (2017).","DOI":"10.3136\/nskkk.64.457"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Zhang, Y.; Zhang, Z.; Tu, C.; Chen, X.; He, R. Advanced glycation end products in disease development and potential interventions. Antioxidants 14, 492 (2025).","DOI":"10.3390\/antiox14040492"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Chen, Y.; Meng, Z.; Li, Y.; Liu, S.; Hu; P.; Luo; E. Advanced glycation end products and reactive oxygen species: uncovering the potential role of ferroptosis in diabetic complications. Mol. Med. 30, 141 (2024).","DOI":"10.1186\/s10020-024-00905-9"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Yamagishi, S.; Matsui, T. Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid. Med. Cell. Longev. 3, 101-108 (2010).","DOI":"10.4161\/oxim.3.2.11148"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Thornalley, P.J. Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch. Biochem. Biophys. 419, 31-40 (2003).","DOI":"10.1016\/j.abb.2003.08.013"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Malik, N.S.; Meek, K.M. The inhibition of sugar-induced structural alterations in collagen by aspirin and other compounds. Biochem. Biophys. Res. Commun. 199, 683-686 (1994).","DOI":"10.1006\/bbrc.1994.1282"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ahmad, S.; Shahab, U.; Baig, M.H.; Khan, M.S.; Khan, M.S. et al. Moinuddin. Inhibitory effect of metformin and pyridoxamine in the formation of early, intermediate and advanced glycation end-products. PLoS One 8, e72128 (2013).","DOI":"10.1371\/journal.pone.0072128"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Ohta, T.; Inoha, M.; Kawahara, C.; Toshimitsu, S.; Shoyama, Y.; Uto, T. Angiotensin I-converting enzyme-inhibitory activity and phytochemical profile of constituents of the leaves of Rehmannia glutinosa f. hueichingensis. Chem. Pharm. Bull. 71, 508-514 (2023).","DOI":"10.1248\/cpb.c22-00524"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kobayashi, H.; Oguchi, H.; Takizawa, N.; Miyase, T.; Ueno, A. et al. New Phenylethanoid glycosides from Cistanche tubulosa (SCHRENK) HOOK. f. I. Chem. Pharm. Bull. 35, 3309-3314 (1987).","DOI":"10.1248\/cpb.35.3309"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Liu, Y.L.; Ho, D.K.; Cassady, J.M.; Cook, V.M.; Baird, W.M. Isolation of potential cancer chemopreventive agents from Eriodictyon californicum. J. Nat. Prod. 55, 357-363 (1992).","DOI":"10.1021\/np50081a012"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Lin, L.C.; Pai, Y.F.; Tsai, T.H. Isolation of luteolin and luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and their pharmacokinetics in rats. J. Agric. Food Chem. 63, 7700-7706 (2015).","DOI":"10.1021\/jf505848z"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Wada, H.; Satake, T.; Murakami, T.; Kojima, T.; Saiki, Y.; Chen, C. Chemische und Chemotaxonomische Untersuchungen der Pterophyten. LIX. Chemische Untersuchungen der Inhaltsstoffe von Alsophila spinulosa TRYON. Chem. Pharm. Bull. 33, 4182-4187 (1985).","DOI":"10.1248\/cpb.33.4182"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Davini, E.; Iavarone, C.; Mataloni, F.; Trogolo, C. Chemistry of oxaziridines. 9.\u2019 Synthesis of 2-sulfonyl- and 2-sulfamyloxaziridines using potassium peroxymonosulfate (Oxone). J. Org. Chem. 53, 2089-2091 (1988).","DOI":"10.1021\/jo00244a043"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kil, Y.S.; Kim, S.M.; Kang, U.; Chung, H.Y.; Seo, E.K. Peroxynitrite-scavenging glycosides from the stem bark of Catalpa ovata. J. Nat. Prod. 80, 2240-2251 (2017).","DOI":"10.1021\/acs.jnatprod.7b00139"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Bai, H.; Li, S.; Yin, F.; Hu, L. Isoprenylated naphthoquinone dimers Firmianones A, B, and C from Firmiana platanifolia. J. Nat. Prod. 68, 1159-1163 (2005).","DOI":"10.1021\/np050019l"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Chen, F.A.; Wu, A.B.; Shieh, P.; Kuo, D.H.; Hsieh, C.Y. Evaluation of the antioxidant activity of Ruellia tuberosa. Food Chem. 94, 14-18 (2006).","DOI":"10.1016\/j.foodchem.2004.09.046"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Liu, H.; Gu, L. Phlorotannins from brown algae (Fucus vesiculosus) inhibited the formation of advanced glycation endproducts by scavenging reactive carbonyls. J. Agric. Food Chem. 60, 1326-1334 (2012).","DOI":"10.1021\/jf204112f"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Krishnaiah, D.; Sarbatly, R.; Nithyanandam, R. A review of the antioxidant potential of medicinal plant species. Food Bioprod. Process. 89, 217-233 (2011).","DOI":"10.1016\/j.fbp.2010.04.008"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Xu, Z.; Dai, X.; Su, S.; Yan, H.; Guo, S. et al. Investigation of dynamic accumulation and regularity of nine glycosides and saccharides in Rehmannia glutinosa by rapid quantitative analysis technology. J. Sep. Sci. 42, 1489-1499 (2019).","DOI":"10.1002\/jssc.201801185"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Oshio, H.; Inouye, H. Iridoid glycosides of Rehmannia glutinosa. Phytochemistry 21, 133-138 (1982).","DOI":"10.1016\/0031-9422(82)80029-0"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Xu, J.; Wu, J.; Zhu, L.Y.; Shen, H.; Xu, J.D. et al. Simultaneous determination of iridoid glycosides, phenethylalcohol glycosides and furfural derivatives in Rehmanniae Radix by high performance liquid chromatography coupled with triple-quadrupole mass spectrometry. Food Chem. 135, 2277-2286 (2012).","DOI":"10.1016\/j.foodchem.2012.07.006"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Patel, R.P.; Svistunenko D.; Wilson M.T.; Darley-Usmar V.M. Reduction of Cu(II) by lipid hydroperoxides: Implications for the copper-dependent oxidation of low-density lipoprotein. Biochem. J. 322, 425-433 (1997).","DOI":"10.1042\/bj3220425"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Bagnati, M.; Bordone, R.; Perugini, C.; Cau, C.; Albano, E.; Bellomo, G. Cu(I) availability paradoxically antagonizes antioxidant consumption and lipid peroxidation during the initiation phase of copper-induced LDL oxidation. Biochem. Biophys. Res. Commun. 253, 235-240 (1998).","DOI":"10.1006\/bbrc.1998.9777"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Vassalle, C.; Petrozzi, L.; Botto, N.; Andreassi, M.G.; Zucchelli, G.C. Oxidative stress and its association with coronary artery disease and different atherogenic risk factors. J. Intern. Med. 256, 308-315 (2004).","DOI":"10.1111\/j.1365-2796.2004.01373.x"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Straface, E.; Matarrese, P.; Gambardella, L.; Vona, R.; Sgadari, A. et al. Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: A pilot study. FEBS Lett. 579, 2759-2766 (2005).","DOI":"10.1016\/j.febslet.2005.03.094"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ukeda, H.; Kawana, D.; Maeda, S.; Sawamura, M. Spectrophotometric assay for superoxide dismutase based on the reduction of highly water-soluble tetrazolium salts by xanthine-xanthine oxidase. Biosci. Biotechnol. Biochem. 63, 485-488 (1999).","DOI":"10.1271\/bbb.63.485"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Goldstein, S.; Czapski, G. Comparison between different assays for superoxide dismutase-like activity. Free Radic. Res. 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