{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:24Z","timestamp":1777937604118,"version":"3.51.4"},"reference-count":42,"publisher":"Japan Oil Chemists' Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2026]]},"DOI":"10.5650\/jos.ess25233","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:15:26Z","timestamp":1777587326000},"page":"537-550","source":"Crossref","is-referenced-by-count":0,"title":["Researching on Optimization and Evaluation Some Biological Activities of Polyphenol Extract from Avocado Seeds (<i>Persea americana<\/i> Mill)"],"prefix":"10.5650","volume":"75","author":[{"given":"Nguyen","family":"Thi Truc Loan","sequence":"first","affiliation":[{"name":"The University of Da Nang, University of Science and Technology, 54 Nguyen Luong Bang, Lien Chieu District, 50000, VIET NAM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Hien","sequence":"additional","affiliation":[{"name":"The University of Da Nang, University of Science and Technology, 54 Nguyen Luong Bang, Lien Chieu District, 50000, VIET NAM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien Hien","family":"Tran","sequence":"additional","affiliation":[{"name":"Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 70000, VIET NAM"},{"name":"Nguyen Tat Thanh University Center for Hi-Tech Development, Saigon Hi-Tech Park, Ho Chi Minh City, VIET NAM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Kim Ngan","family":"Tran","sequence":"additional","affiliation":[{"name":"Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 70000, VIET NAM"},{"name":"Nguyen Tat Thanh University Center for Hi-Tech Development, Saigon Hi-Tech Park, Ho Chi Minh City, VIET NAM"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1) Galindo-Tovar, M.E.; Arzate-Fern\u00e1ndez, A.M.; Ogata-Aguilar, N.; Landero-Torres, I. The avocado (Persea americana, Lauraceae) crop in Mesoamerica: 10,000 years of history. Harvard Pap. Bot. 12, 325-334 (2007). doi: 10.3100\/1043-4534(2007)12[325:tapalc]2.0.co;2","DOI":"10.3100\/1043-4534(2007)12[325:TAPALC]2.0.CO;2"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) Bangar, S.P.; Dunno, K.; Dhull, S.B.; Kumar Siroha, A.; Changan, S. et al. Avocado seed discoveries: chemical composition, biological properties, and industrial food applications. Food Chem. X 16, 100507 (2022). doi:10.1016\/j.fochx.2022.100507","DOI":"10.1016\/j.fochx.2022.100507"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Ejiofor, N.C.; Ezeagu, I.E.; Ayoola, M.B.; Umera, E.A. Determination of the chemical composition of avocado (Persea americana) seed. Adv. Food Technol. Nutr. Sci. Open J. SE, S51-S55 (2018). doi:10.17140\/AFTNSOJ-SE-2-107","DOI":"10.17140\/AFTNSOJ-SE-2-107"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ramos-Jerz, M.R.; Villanueva, S.; Jerz, G.; Winterhalter, P.; Deters, A.M. Persea americana Mill. seed: fractionation, characterization, and effects on human keratinocytes and fibroblasts. Evid. Based Complement. Alternat. Med. 2013, 391247 (2013).","DOI":"10.1155\/2013\/391247"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5) Bahru, T.B.; Tadele, Z.H.; Ajebe, E.G. A review on avocado seed: functionality, composition, antioxidant and antimicrobial properties. Chem. Sci. Int. J. 27, 1-10 (2019). doi:10.9734\/CSJI\/2019\/v27i230112","DOI":"10.9734\/CSJI\/2019\/v27i230112"},{"key":"6","doi-asserted-by":"publisher","unstructured":"17) Lee, S.G.; Yu, M.H.; Lee, S.P.; Lee, I.S. Antioxidant activities and induction of apoptosis by methanol extracts from avocado. J. Korean Soc. Food Sci. Nutr. 37, 269-275 (2008). doi:10.3746\/jkfn.2008.37.3.269","DOI":"10.3746\/jkfn.2008.37.3.269"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Dabas, D.; Elias, R.J.; Lambert, J.D.; Ziegler, G.R. A colored avocado seed extract as a potential natural colorant. J. Food Sci. 76, C1335-C1341 (2011).","DOI":"10.1111\/j.1750-3841.2011.02415.x"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) G\u00f3mez, F.S.; S\u00e1nchez, S.P.; Gallego Iradi, M.G.; Mohd Azman, N.A.; Almajano, M.P. Avocado seeds: extraction optimization and possible use as antioxidant in food. Antioxidants 3, 439-454 (2014).","DOI":"10.3390\/antiox3020439"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Rodr\u00edguez-Carpena, J.G.; Morcuende, D.; Andrade, M.J.; Kylli, P.; Est\u00e9vez, M. Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties. J. Agric. Food Chem. 59, 5625-5635 (2011).","DOI":"10.1021\/jf1048832"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10) Asiwe, E.S.; Igwe, C.U.; Iheanacho, K.M.E.; Onyeocha, I.O.; Onwuliri, V.A. Bioactive composition and acute oral toxicity studies on Persea americana seed ethyl acetate fraction. Asian J. Res. Biochem. 8, 10-17 (2021). doi: 10.9734\/ajrb\/2021\/v8i430186","DOI":"10.9734\/ajrb\/2021\/v8i430186"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Ahmed, T.; Rana, M.R.; Hossain, M.A.; Ullah, S.; Suzauddula, M. Optimization of ultrasound-assisted extraction using response surface methodology for total anthocyanin content, total phenolic content, and antioxidant activities of roselle (Hibiscus sabdariffa L.) calyces and comparison with conventional Soxhlet extraction. Biomass Convers. Biorefin. 14, 28985-28999 (2024).","DOI":"10.1007\/s13399-023-03881-y"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Pereira, A.G.; Cruz, L.; Cassani, L.; Chamorro, F.; Louren\u00e7o-Lopes, C. et al. Comparative study of microwave-assisted extraction and ultrasound-assisted extraction techniques (MAE vs. UAE) for the optimized production of enriched extracts in phenolic compounds of Camellia japonica var. Eugenia de Montijo. Eng. Proc. 37, 124 (2023).","DOI":"10.3390\/ECP2023-14615"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) Pereira, T.C.; Souza, V.P.; Padilha, A.P.F.; Duarte, F.A.; Flores, E.M.M. Trends and perspectives on the ultrasound-assisted extraction of bioactive compounds using natural deep eutectic solvents. Curr. Opin. Chem. Eng. 47, 101088 (2025). doi: 10.1016\/j.coche.2024.101088","DOI":"10.1016\/j.coche.2024.101088"},{"key":"14","unstructured":"14) Negm, S.H.; Abo-Raya, A.O. Therapeutic effects of avocado (Persea americana Mill) fruits and seeds on immune deficiency in rats. J. Res. Spec. Educ. Fields 4, 293-301 (2018)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Villarreal-Lara, R.; Rodr\u00edguez-S\u00e1nchez, D.G.; D\u00edaz De La Garza, R.I.; Garc\u00eda-Cruz, M.I.; Castillo, A. et al. Purified avocado seed acetogenins: antimicrobial spectrum and complete inhibition of Listeria monocytogenes in a refrigerated food matrix. CyTA J. Food 17, 228-239 (2019).","DOI":"10.1080\/19476337.2019.1575908"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Laksmiani, N.P.L.; Sanjaya, I.K.N.; Leliqia, N.P.E. The activity of avocado (Persea americana Mill.) seed extract containing catechin as a skin lightening agent. J. Pharm. Pharmacogn. Res. 8, 449-456 (2020).","DOI":"10.56499\/jppres20.836_8.5.449"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17) Lee, S.G.; Yu, M.H.; Lee, S.P.; Lee, I.S. Antioxidant activities and induction of apoptosis by methanol extracts from avocado. J. Korean Soc. Food Sci. Nutr. 37, 269-275 (2008). doi:10.3746\/jkfn.2008.37.3.269","DOI":"10.3746\/jkfn.2008.37.3.269"},{"key":"18","unstructured":"18) Putri, T.W.; Rajab, R.A.; Raya, I. The potential of Chlorella vulgaris and avocado seed oil as anti-aging cream material. Int. J. Sci. Technol. Res. 8, 2277-2281 (2019)."},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Sharshir, S.W.; Joseph, A.; Peng, G.; Kandeal, A.W.; Abdullah, A.S. et al. Recent efforts in developing agricultural product drying processes using solar energy. Sol. Energy 257, 137-154 (2023). doi:10.1016\/j.solener.2023.04.022","DOI":"10.1016\/j.solener.2023.04.022"},{"key":"20","unstructured":"20) Njoku, O.V.; Obi, C. Phytochemical constituents of some selected medicinal plants. Afr. J. Pure Appl. Chem. 3, 228-233 (2009)."},{"key":"21","doi-asserted-by":"publisher","unstructured":"10) Asiwe, E.S.; Igwe, C.U.; Iheanacho, K.M.E.; Onyeocha, I.O.; Onwuliri, V.A. Bioactive composition and acute oral toxicity studies on Persea americana seed ethyl acetate fraction. Asian J. Res. Biochem. 8, 10-17 (2021). doi: 10.9734\/ajrb\/2021\/v8i430186","DOI":"10.9734\/ajrb\/2021\/v8i430186"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Singh, R.; Singh, S.; Kumar, S.; Arora, S. Evaluation of antioxidant potential of ethyl acetate extract\/fractions of Acacia auriculiformis A. Cunn. Food Chem. Toxicol. 45, 1216-1223 (2007).","DOI":"10.1016\/j.fct.2007.01.002"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Alam, M.K.; Rana, Z.H.; Islam, S.N.; Akhtaruzzaman, M. Total phenolic content and antioxidant activity of methanolic extract of selected wild leafy vegetables grown in Bangladesh: a cheapest source of antioxidants. Slovak J. Food Sci. 13, 201-210 (2019).","DOI":"10.5219\/1107"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Raju, N.V.; Sukumar, K.; Reddy, G.B.; Pankaj, P.K.; Annapareddy, S. In-vitro studies on antitumour and antimicrobial activities of methanolic kernel extract of Mangifera indica L. cultivar Banganapalli. Biomed. Pharmacol. J. 12, 357-362 (2019).","DOI":"10.13005\/bpj\/1648"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Setyawan, H.Y.; Sukardi, S.; Puriwangi, C.A. Phytochemicals properties of avocado seed: a review. IOP Conf. Ser. Earth Environ. Sci. 733, 012090 (2021).","DOI":"10.1088\/1755-1315\/733\/1\/012090"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Lai, T.N.H.; Andr\u00e9, C.M.; Chirinos, R.; Nguyen, T.B.T.; Larondelle, Y.; Rogez, H. Optimisation of extraction of piceatannol from Rhodomyrtus tomentosa seeds using response surface methodology. Sep. Purif. Technol. 134, 139-146 (2014).","DOI":"10.1016\/j.seppur.2014.07.032"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Wang, W.; Bostic, T.R.; Gu, L. Antioxidant capacities, procyanidins and pigments in avocados of different strains and cultivars. Food Chem. 122, 1193-1198 (2010).","DOI":"10.1016\/j.foodchem.2010.03.114"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28) Vinatoru, M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrason. Sonochem. 8, 303-313 (2001). doi:10.1016\/S1350-4177(01)00071-2","DOI":"10.1016\/S1350-4177(01)00071-2"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Pandey, A.; Belwal, T.; Sekar, K.C.; Bhatt, I.D.; Rawal, R.S. Optimization of ultrasonic-assisted extraction (UAE) of phenolics and antioxidant compounds from rhizomes of Rheum moorcroftianum using response surface methodology (RSM). Ind. Crops Prod. 119, 218-225 (2018).","DOI":"10.1016\/j.indcrop.2018.04.019"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Garcia-Vallejo, M.C.; Solarte-Toro, J.C.; Ortiz-Sanchez, M.; Chamorro-Anaya, L.; Peroza-Pi\u00f1eres, P. et al. Exploring the production of antioxidants and biogas from avocado (Persea americana var. americana) residues as an alternative for developing rural bioeconomies. Sustain. Chem. Pharm. 33, 101089 (2023).","DOI":"10.1016\/j.scp.2023.101089"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31) Gai, F.; Peiretti, P.G.; Karama\u0107, M.; Amarowicz, R. Changes in the total polyphenolic content and antioxidant capacities of perilla (Perilla frutescens L.) plant extracts during the growth cycle. J. Food Qual. 2017, 7214747 (2017). doi: 10.1155\/2017\/7214747","DOI":"10.1155\/2017\/7214747"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Tan, C.X.; Chong, G.H.; Hamzah, H.; Ghazali, H.M. Comparison of subcritical CO2 and ultrasound-assisted aqueous methods with the conventional solvent method in the extraction of avocado oil. J. Supercrit. Fluids 135, 45-51 (2018).","DOI":"10.1016\/j.supflu.2017.12.036"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Segovia, F.J.; Corral-P\u00e9rez, J.J.; Almajano, M.P. Avocado seed: modeling extraction of bioactive compounds. Ind. Crops Prod. 85, 213-220 (2016).","DOI":"10.1016\/j.indcrop.2016.03.005"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Munthe, S.W.N.; Riskianto, R.; Juvi, D.; Novia, J. Antioxidant, total phenolic, and total flavonoid of 70 % ethanol extract of avocado seeds (Persea americana Mill.). Pharmacogn. J. 15, 668-672 (2023).","DOI":"10.5530\/pj.2023.15.126"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35) Kupnik, K.; Primo\u017ei\u010d, M.; Kokol, V.; Knez, \u017d.; Leitgeb, M. Enzymatic, antioxidant, and antimicrobial activities of bioactive compounds from avocado (Persea americana L.) seeds. Plants 12, 1201 (2023).","DOI":"10.3390\/plants12051201"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36) da Silva, G.G.; Pimenta, L.P.S.; Melo, J.O.F.; Mendon\u00e7a, H.de O.P.; Augusti, R.; Takahashi, J.A. Phytochemicals of avocado residues as potential acetylcholinesterase inhibitors, antioxidants, and neuroprotective agents. Molecules 27, 1892 (2022).","DOI":"10.3390\/molecules27061892"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Oboh, G.; Odubanjo, V.O.; Bello, F.; Ademosun, A.O.; Oyeleye, S.I. et al. Aqueous extracts of avocado pear (Persea americana Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro. J. Basic Clin. Physiol. Pharmacol. 27, 131-140 (2016).","DOI":"10.1515\/jbcpp-2015-0049"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Molyneux, C.S.; Peshu, N.; Marsh, K. Understanding of informed consent in a low-income setting: three case studies from the Kenyan Coast. Soc. Sci. Med. 59, 2547-2559 (2004).","DOI":"10.1016\/j.socscimed.2004.03.037"},{"key":"39","doi-asserted-by":"publisher","unstructured":"39) Alara, O.R.; Abdurahman, N.H.; Ukaegbu, C.I. Extraction of phenolic compounds: a review. Curr. Res. Food Sci. 4, 200-214 (2021). doi:10.1016\/j.crfs.2021.03.011","DOI":"10.1016\/j.crfs.2021.03.011"},{"key":"40","unstructured":"40) Gusti, N. Overview the botanical, phytochemical and antibacterial activity the avocado plant (Persea americana Mill.). World J. Pharm. Pharm. Sci. 9, 2602-2620 (2020)."},{"key":"41","doi-asserted-by":"publisher","unstructured":"2) Bangar, S.P.; Dunno, K.; Dhull, S.B.; Kumar Siroha, A.; Changan, S. et al. Avocado seed discoveries: chemical composition, biological properties, and industrial food applications. Food Chem. X 16, 100507 (2022). doi:10.1016\/j.fochx.2022.100507","DOI":"10.1016\/j.fochx.2022.100507"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Segovia, F.J.; Corral-P\u00e9rez, J.J.; Almajano, M.P. Avocado seed: modeling extraction of bioactive compounds. Ind. Crops Prod. 85, 213-220 (2016).","DOI":"10.1016\/j.indcrop.2016.03.005"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/75\/5\/75_jos.ess25233\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:10:41Z","timestamp":1777695041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/75\/5\/75_jos.ess25233\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess25233","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"jos.ess25233"}}