{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:51:23Z","timestamp":1775278283370,"version":"3.50.1"},"reference-count":49,"publisher":"Japan Oil Chemists' Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2026]]},"DOI":"10.5650\/jos.ess25242","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:13:27Z","timestamp":1774995207000},"page":"455-464","source":"Crossref","is-referenced-by-count":0,"title":["&lt;i&gt;Folliculi sennae&lt;\/i&gt; Extract: A Multifunctional Approach to Alzheimer's and Diabetes"],"prefix":"10.5650","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-9893","authenticated-orcid":false,"given":"Turkan","family":"Guney","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Bilecik Seyh Edebali University, Bilecik,11230 T\u00dcRKIYE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"Altin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art, Erzincan Binali Y\u0131ld\u0131r\u0131m University, Erzincan 24100, T\u00dcRKIYE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3086-8156","authenticated-orcid":false,"given":"Emrah","family":"Dikici","sequence":"additional","affiliation":[{"name":"Dogubayazit Ahmed-i Hani Vocational School, Agri Ibrahim Cecen University, Agri, 04400, T\u00dcRKIYE"},{"name":"Agri Ibrahim Cecen University, Central Researching Laboratory, Agri, 04100, T\u00dcRKIYE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-8104","authenticated-orcid":false,"given":"Mesut","family":"Isik","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Bilecik \u015eeyh Edebali University, Bilecik, 11230, T\u00dcRKIYE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekrem","family":"Koksal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Art, Erzincan Binali Y\u0131ld\u0131r\u0131m University, Erzincan 24100, T\u00dcRKIYE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1) Jomova, K.; Raptova, R.; Alomar, S.Y.; Alwasel, S.H.; Nepovimova, E. et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch. Toxicol. 97, 2499-2574 (2023). doi:10.1007\/s00204-023-03562-9","DOI":"10.1007\/s00204-023-03562-9"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) Domanskyi, A.; Parlato, R. Oxidative stress in neurodegenerative diseases. Antioxidants 11, 504 (2022). doi:10.3390\/antiox11030504","DOI":"10.3390\/antiox11030504"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Xu, F.; Shi, J. Insulin signaling and oxidative stress: Bridging the gap between type 2 diabetes mellitus and Alzheimer&apos;s disease. J. Alzheimers Dis. 103, 994-1004 (2025). doi:10.1177\/13872877241307404","DOI":"10.1177\/13872877241307404"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) Sies, H. Oxidative eustress: The physiological role of oxidants. Sci. China Life Sci. 66, 1947-1948 (2023). doi:10.1007\/s11427-023-2336-1","DOI":"10.1007\/s11427-023-2336-1"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5) Sadiq, I.Z. Free radicals and oxidative stress: Signaling mechanisms, redox basis for human diseases, and cell cycle regulation. Curr. Mol. Med. 23, 13-35 (2023). doi:10.2174\/1566524022666211222161637","DOI":"10.2174\/1566524022666211222161637"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Chaudhary, P.; Janmeda, P.; Docea, A.O.; Yeskaliyeva, B.; Abdull Razis, A.F. et al. Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Front. Chem. 11, 1158198 (2023). doi:10.3389\/fchem.2023.1158198","DOI":"10.3389\/fchem.2023.1158198"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7) Karran, E.; De Strooper, B. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nat. Rev. Drug Discov. 21, 306-318 (2022). doi:10.1038\/s41573-022-00391-w","DOI":"10.1038\/s41573-022-00391-w"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) Andrade, L.J.D.O.; Oliveira, L.M.D.; Bittencourt, A.M.V.; Louren\u00e7o, L.G.D.C.; Oliveira, G.C.M.D. Brain insulin resistance and Alzheimer&apos;s disease: A systematic review. Dement. Neuropsychol. 18, e20230032 (2024). doi:10.1590\/1980-5764-DN-2023-0032","DOI":"10.1590\/1980-5764-dn-2023-0032"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) Giacobini, E.; Cuello, A.C.; Fisher, A. Reimagining cholinergic therapy for Alzheimer&apos;s disease. Brain 145, 2250-2275 (2022). doi:10.1093\/brain\/awac096","DOI":"10.1093\/brain\/awac096"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10) Anand, P.; Singh, B. A review on cholinesterase inhibitors for Alzheimer&apos;s disease. Arch. Pharm. Res. 36, 375-399 (2013). doi:10.1007\/s12272-013-0036-3","DOI":"10.1007\/s12272-013-0036-3"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11) Moreira, N.C.D.S.; Lima, J.E.B.F.; Marchiori, M.F.; Carvalho, I.; Sakamoto-Hojo, E.T. Neuroprotective effects of cholinesterase inhibitors: Current scenario in therapies for Alzheimer&apos;s disease and future perspectives. J. Alzheimers Dis. Rep. 6, 177-193 (2022). doi:10.3233\/ADR-210061","DOI":"10.3233\/ADR-210061"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12) Qin, Q.N.X.; Ming, L.C.; Abd Wahab, M.S.; Tan, C.S.; Yuda, A.; Hermansyah, A. Drug-related problems among older people with dementia: A systematic review. Res. Soc. Adm. Pharm. 19, 873-881 (2023). doi:10.1016\/j.sapharm.2023.02.015","DOI":"10.1016\/j.sapharm.2023.02.015"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) \u0106orkovi\u0107, I.; Ga\u0161o-Soka\u010d, D.; Pichler, A.; \u0160imunovi\u0107, J.; Kopjar, M. Dietary polyphenols as natural inhibitors of \u03b1-amylase and \u03b1-glucosidase. Life 12, 1692 (2022). doi:10.3390\/life12111692","DOI":"10.3390\/life12111692"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14) Nie, T.; Cooper, G.J.S. Mechanisms underlying the antidiabetic activities of polyphenolic compounds: A review. Front. Pharmacol. 12, 798329 (2021). doi:10.3389\/fphar.2021.798329","DOI":"10.3389\/fphar.2021.798329"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15) Lam, T.P.; Tran, N.N.; Pham, L.D.; Lai, N.V.; Dang, B.N. et al. Flavonoids as dual-target inhibitors against \u03b1-glucosidase and \u03b1-amylase: A systematic review of in vitro studies. Nat. Prod. Bioprospect. 14, 4 (2024). doi:10.1007\/s13659-023-00424-w","DOI":"10.1007\/s13659-023-00424-w"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16) Uuh Narvaez, J.J.; Segura Campos, M.R. Combination therapy of bioactive compounds with acarbose: A proposal to control hyperglycemia in type 2 diabetes. J. Food Biochem. 46, e14268 (2022). doi:10.1111\/jfbc.14268","DOI":"10.1111\/jfbc.14268"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17) Yanai, H.; Adachi, H.; Hakoshima, M.; Katsuyama, H. Postprandial hyperlipidemia: Its pathophysiology, diagnosis, atherogenesis, and treatments. Int. J. Mol. Sci. 24, 13942 (2023). doi:10.3390\/ijms241813942","DOI":"10.3390\/ijms241813942"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18) Singh, K.; Gupta, J.K.; Chanchal, D.K.; Shinde, M.G.; Kumar, S. et al. Natural products as drug leads: Exploring their potential in drug discovery and development. Naunyn-Schmiedeberg&apos;s Arch. Pharmacol. 398, 4673-4687 (2025). doi:10.1007\/s00210-024-03622-6","DOI":"10.1007\/s00210-024-03622-6"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Sai Priya, T.; Ramalingam, V.; Suresh Babu, K. Natural products: A potential immunomodulators against inflammatory-related diseases. Inflammopharmacology 32, 2821-2859 (2024). doi:10.1007\/s10787-024-01562-4","DOI":"10.1007\/s10787-024-01562-4"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20) Atanasov, A.G.; Zotchev, S.B.; Dirsch, V.M.; International natural product sciences taskforce; Supuran C.T. Natural products in drug discovery: Advances and opportunities. Nat. Rev. Drug Discov. 20, 200-216 (2021). doi:10.1038\/s41573-020-00114-z","DOI":"10.1038\/s41573-020-00114-z"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21) Gulcin \u0130. Antioxidants and antioxidant methods: An updated overview. Arch. Toxicol. 94, 651-715 (2020). doi:10.1007\/s00204-020-02689-3","DOI":"10.1007\/s00204-020-02689-3"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22) Thaker, K.; Patoliya, J.; Rabadiya, K.; Reddy, N.R.R.; Joshi, R. Senna (Cassia angustifolia Vahl.): A comprehensive review of ethnopharmacology and phytochemistry. Pharmacol. Res. Nat. Prod. 1, 100003 (2023). doi:10.1016\/j.prenap.2023.100003","DOI":"10.1016\/j.prenap.2023.100003"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Morid Ahmadi, D.; Mojtabavi, S.; Ghadami, S.; Eftekhari, M.; Shams Ardekani, M.R. et al. Cassia angustifolia Vahl. Leaves: Determination of Total Phenolic and Sennoside Contents of Different Fractions in Comparison with Their \u03b1- Glucosidase and Tyrosinase Inhibitory Effects. Iran. J. Pharm. Res. 23, e140914 (2024). doi:10.5812\/ijpr-140914","DOI":"10.5812\/ijpr-140914"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24) I\u015f\u0131k, M.; Dikici, E.; Alt\u0131n, S.; Alp, C.; K\u0131rbo\u011fa, K.K. et al. Phenolic content, antioxidant capacity, and therapeutic potential of mango (Mangifera indica L.) leaves. Food Sci. Nutr. 13, e70263 (2025). doi:10.1002\/fsn3.70263","DOI":"10.1002\/fsn3.70263"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25) Alt\u0131n, S.; I\u015f\u0131k, M.; Alp, C.; Dikici, E.; K\u00f6ksal, E. et al. Therapeutic potential of Laurus nobilis extract by experimental and computational approaches: Phenolic content and bioactivities for antioxidant, antidiabetic, and anticholinergic properties. Front. Chem. 13, 1541250 (2025). doi:10.3389\/fchem.2025.1541250","DOI":"10.3389\/fchem.2025.1541250"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Kavaz Y\u00fcksel, A.; Dikici, E.; Y\u00fcksel, M.; I\u015f\u0131k, M.; Tozo\u011flu, F.; K\u00f6ksal, E. Phytochemical, phenolic profile, antioxidant, anticholinergic and antibacterial properties of Epilobium angustifolium (Onagraceae). J. Food Meas. Charact. 15, 4858-4867 (2021).","DOI":"10.1007\/s11694-021-01050-1"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) Yilmaz, M.A. Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: A detailed, robust and comprehensive LC\u2013MS\/MS method validation. Ind. Crops Prod. 149, 112347 (2020). doi:10.1016\/j.indcrop.2020.112347","DOI":"10.1016\/j.indcrop.2020.112347"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ellman, G.L.; Courtney, K.D.; Andres Jr., V.; Featherstone, R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95 (1961).","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29) Tao, Y.; Zhang, Y.; Cheng, Y.; Wang, Y. Rapid screening and identification of \u03b1-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC\/MS and NMR. Biomed. Chromatogr. 27, 148-155 (2013). doi:10.1002\/bmc.2761","DOI":"10.1002\/bmc.2761"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30) Blois, M.S. Antioxidant determinations by the use of a stable free radical. Nature 181, 1199-1200 (1958). doi:10.1038\/1811199a0","DOI":"10.1038\/1811199a0"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31) Kavaz, A.; I\u015f\u0131k, M.; Dikici, E.; Y\u00fcksel, M. Anticholinergic, antioxidant, and antibacterial properties of Vitex agnus-castus L. seed extract: Assessment of its phenolic content by LC\/MS\/MS. Chem. Biodivers. 19, e202200143 (2022). doi:10.1002\/cbdv.202200143","DOI":"10.1002\/cbdv.202200143"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M. Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 26, 1231-1237 (1999). doi:10.1016\/S0891-5849(98)00315-3","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33) Oyaizu, M. Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn. J. Nutr. Diet. 44, 307-315 (1986). doi:10.5264\/eiyogakuzashi.44.307","DOI":"10.5264\/eiyogakuzashi.44.307"},{"key":"34","unstructured":"34) Y\u00fcksel, A.K.; Dikici, E.; Y\u00fcksel, M.; I\u015fik, M.; Tozo\u011flu, F.; K\u00f6ksal, E. Phytochemicals analysis and some bioactive properties of Erica manipuliflora Salisb.(EMS); Antibacterial, antiradical and anti-lipid peroxidation. Iran. J. Pharm. Res. 20, 422 (2021). doi:10.22037\/ijpr.2021.115270.15288"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35) G\u00fczel, A. Phytochemical analysis and antioxidant, anticholinesterase and antiatherogenic activity of hairy tea (Stachys lavandulifolia). J. Inst. Sci. Technol. 13, 2809-2817 (2023). doi:10.21597\/jist.1309555","DOI":"10.21597\/jist.1309555"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36) Apak, R.; G\u00fc\u00e7l\u00fc, K.; \u00d6zy\u00fcrek, M.; Karademir, S.E.; Er\u00e7\u01e7, E. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. Int. J. Food Sci. Nutr. 57, 292-304 (2006). doi:10.1080\/09637480600798132","DOI":"10.1080\/09637480600798132"},{"key":"37","doi-asserted-by":"publisher","unstructured":"37) Ndhlala, A.R.; I\u015f\u0131k, M.; Kavaz Y\u00fcksel, A.; Dikici, E. Phenolic content analysis of two species belonging to the lamiaceae family: Antioxidant, anticholinergic, and antibacterial activities. Molecules 29, 480 (2024). doi:10.3390\/molecules29020480","DOI":"10.3390\/molecules29020480"},{"key":"38","doi-asserted-by":"publisher","unstructured":"38) G\u00fczel, A. Relationship between phenolic content determined by LC\/MS\/MS and antioxidant capacity and enzyme inhibition of Cyclotrichium niveum L. Chem. Biodivers. 20, e202300027 (2023). doi:10.1002\/cbdv.202300027","DOI":"10.1002\/cbdv.202300027"},{"key":"39","doi-asserted-by":"publisher","unstructured":"39) Rana, A.; Samtiya, M.; Dhewa, T.; Mishra, V.; Aluko, R.E. Health benefits of polyphenols: A concise review. J. Food Biochem. 46, e14264 (2022). doi:10.1111\/jfbc.14264","DOI":"10.1111\/jfbc.14264"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40) Rudrapal, M.; Khairnar, S.J.; Khan, J.; Dukhyil, A.B.; Ansari, M.A. et al. Dietary polyphenols and their role in oxidative stress-induced human diseases: Insights into protective effects, antioxidant potentials and mechanisms of action. Front. Pharmacol. 13, 806470 (2022). doi:10.3389\/fphar.2022.806470","DOI":"10.3389\/fphar.2022.806470"},{"key":"41","doi-asserted-by":"publisher","unstructured":"41) G\u00fczel, A.; U\u011fur, Y.; \u00d6ner, E.; Kola\u00e7, T. Comparative analysis of phytochemical content and antioxidants, anti-cholinesterase, anti-aterojenik and molecular docking of Turkish Pelargonium (Pelargonium endlicherianum Fenzl.). South African Journal of Botany 179, 124-133 (2025). doi:10.1016\/j.sajb.2025.02.017","DOI":"10.1016\/j.sajb.2025.02.017"},{"issue":"1","key":"42","first-page":"25","volume":"37","year":"2024","unstructured":"42) G\u00fczel, A. Assessment of antioxidant, acetylcholinesterase, paraoxonase inhibition activities and phenolic content of Alchemilla lithophila. Pakistan Journal of Pharmaceutical Sciences 37(1), 25-32 (2024). doi:10.36721\/PJPS.2024.37.1.REG.025-032.1","journal-title":"Pakistan Journal of Pharmaceutical Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/1011-601X","issn-type":"print"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Bekdash, R.A. The cholinergic system, the adrenergic system and the neuropathology of Alzheimer&apos;s disease. Int. J. Mol. Sci. 22, 1273 (2021). doi:10.3390\/ijms22031273","DOI":"10.3390\/ijms22031273"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44) Cichon, N.; Grabowska, W.; Gorniak, L.; Stela, M.; Harmata, P. et al. Mechanistic and therapeutic insights into flavonoid-based inhibition of acetylcholinesterase: Implications for neurodegenerative diseases. Nutrients 17, 78 (2024). doi:10.3390\/nu17010078","DOI":"10.3390\/nu17010078"},{"key":"45","doi-asserted-by":"publisher","unstructured":"45) Taqui, R.; Debnath, M.; Ahmed, S.; Ghosh, A. Advances on plant extracts and phytocompounds with acetylcholinesterase inhibition activity for possible treatment of Alzheimer&apos;s disease. Phytomed. Plus 2, 100184 (2022). doi:10.1016\/j.phyplu.2021.100184","DOI":"10.1016\/j.phyplu.2021.100184"},{"key":"46","doi-asserted-by":"publisher","unstructured":"46) Ali, J.; Choe, K.; Park, J.S.; Park, H.Y.; Kang, H. et al. The interplay of protein aggregation, genetics, and oxidative stress in Alzheimer&apos;s disease: Role for natural antioxidants and immunotherapeutics. Antioxidants 13, 862 (2024). doi:10.3390\/antiox13070862","DOI":"10.3390\/antiox13070862"},{"key":"47","doi-asserted-by":"publisher","unstructured":"47) Huang, X.; Sun, W.; Sun, C.; Tan, J.; Wu, L.; Yang, F. Effects of ethanol extract from senna leaf (EESL) on inflammation and oxidative stress in mice: A non-targeted metabolomic study. Endocr. Metab. Immune Disord. Drug Targets 25, 695-709 (2025). doi:10.2174\/0118715303325372241014152811","DOI":"10.2174\/0118715303325372241014152811"},{"key":"48","doi-asserted-by":"publisher","unstructured":"48) Buccellato, F.R.; D&apos;Anca, M.; Fenoglio, C.; Scarpini, E.; Galimberti, D. Role of oxidative damage in Alzheimer&apos;s disease and neurodegeneration: From pathogenic mechanisms to biomarker discovery. Antioxidants 10, 1353 (2021). doi:10.3390\/antiox10091353","DOI":"10.3390\/antiox10091353"},{"key":"49","doi-asserted-by":"publisher","unstructured":"49) Alimpi\u0107 Caradski, A.; Oal\u0111e Pavlovi\u0107, M.; Jankovi\u0107, S.; Marin, P.D.; Duleti\u0107-Lau\u0161evi\u0107, S. Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants. Nat. Med. Mater. 41, 72-105 (2021). doi:10.5937\/leksir2141072A","DOI":"10.5937\/leksir2141072a"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/75\/4\/75_jos.ess25242\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:58:23Z","timestamp":1775275103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/75\/4\/75_jos.ess25242\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess25242","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"jos.ess25242"}}