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Formulation and quality assessment of a nasal spray product from <i>Ageratum conyzoides<\/i> L. extract to support the treatment of rhinosinusitis. Vietnam J. Community Med. 66, 178-183 (2025). doi:10.52163\/yhc.v66iCD18.3472","DOI":"10.52163\/yhc.v66iCD18.3472"},{"key":"9","unstructured":"9) Nguyen, T.T. Medicinal plants and remedies of Vietnam. Medical Publishing House, Hanoi (2013)."},{"key":"10","unstructured":"10) Vu, V.T.; Nguyen, T.P.; Phuong, T.T. Chemical composition of SP3 extract from <i>Ageratum conyzoides<\/i> L. raw material for the production of Agerhinin nasal spray. J. Med. Plants 21, 356-361 (2016)."},{"key":"11","doi-asserted-by":"publisher","unstructured":"11) Dung, N.X.; Tho, P.T.T.; Dan, N.V.; Leclercq, P.A. Chemical composition of the oil of <i>Ageratum conyzoides<\/i> L. from Vietnam. J. Essent. 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GC\/MS-olfactometric characterization of the volatile compounds and determination of antimicrobial and antioxidant activity of essential oil from <i>Calendula officinalis<\/i> L. flowers. J. Essent. Oil-Bear. Plants 22, 1571-1580 (2019). doi10.1080\/0972060X.2019.1703829","DOI":"10.1080\/0972060X.2019.1703829"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26) Nguyen, Q.V.; Eun, J.B. Antioxidant activity of solvent extracts from Vietnamese medicinal plants. J. Med. Plants Res. 5, 2798-2811 (2013). doi10.5897\/JMPR11.1592","DOI":"10.5897\/JMPR11.1592"},{"key":"27","unstructured":"27) Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 30th ed.; CLSI supplement M100. CLSI, Wayne, PA, USA (2020)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Vlietinck, A.J. 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