{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:58:23Z","timestamp":1785560303846,"version":"3.56.0"},"reference-count":35,"publisher":"Japan Oil Chemists' Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Oleo Sci."],"published-print":{"date-parts":[[2026]]},"DOI":"10.5650\/jos.ess26054","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:13:55Z","timestamp":1785536035000},"page":"985-997","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic Lipase Inhibition by Polyphenols in Persimmon Leaf Tea"],"prefix":"10.5650","volume":"75","author":[{"given":"Mohammad Ariful Islam","family":"Bhuiya","sequence":"first","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Tottori University (4-5-6 Koyama-cho Minami, Tottori, Tottori 680-8553, JAPAN)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yoshikiyo","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Tottori University (4-5-6 Koyama-cho Minami, Tottori, Tottori 680-8553, JAPAN)"},{"name":"Faculty of Life and Environmental Sciences, Shimane University (1060 Nishikawatsu-cho, Matsue, Shimane 690-8504, JAPAN)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Tsurunaga","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Tottori University (4-5-6 Koyama-cho Minami, Tottori, Tottori 680-8553, JAPAN)"},{"name":"Faculty of Human Science, Shimane University (1060 Nishikawatsu-cho, Matsue, Shimane 690-8504, JAPAN)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9354-2918","authenticated-orcid":false,"given":"Kaeko","family":"Murota","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Tottori University (4-5-6 Koyama-cho Minami, Tottori, Tottori 680-8553, JAPAN)"},{"name":"Faculty of Life and Environmental Sciences, Shimane University (1060 Nishikawatsu-cho, Matsue, Shimane 690-8504, JAPAN)"},{"name":"Graduate School of Agriculture, Osaka Metropolitan University (1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, JAPAN)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3621","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1) Hossain, A.; Shahidi, F. Persimmon leaves: nutritional, pharmaceutical, and industrial potential-a review. Plants 12, 937 (2023). doi:10.3390\/plants12040937","DOI":"10.3390\/plants12040937"},{"key":"2","first-page":"215","volume":"29","year":"2024","unstructured":"2) Hong, C.; Wang, X.; Xu, J.; Guo, J.; Peng, H., et al. A review: pharmacological effect of natural compounds in <i>Diospyros kaki<\/i> leaves from the perspective of oxidative stress. Molecules 29, 215 (2024). doi:10.3390\/molecules29010215","journal-title":"Molecules","ISSN":"https:\/\/id.crossref.org\/issn\/1420-3049","issn-type":"print"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Tsurunaga, Y.; Matsuzaki, H.; Mochida, K.; Itamura, H. Effects of manufacturing process on functionality and functional component of persimmon leaf tea. Nippon Shokuhin Kagaku Kogaku Kaishi 51, 401-405 (2004). doi:10.3136\/nskkk.51.401","DOI":"10.3136\/nskkk.51.401"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) Tsurunaga, Y.; Takabayashi, Y.; Suzuki, Y.; Nishi, M.; Matsumoto, S. Effects of exudation method on antioxidative component content of persimmon leaf tea and stability of its decoction. Food Preserv. Sci. 35, 309-314 (2009). doi:10.5891\/jafps.35.309","DOI":"10.5891\/jafps.35.309"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5) Chang, Y.-L.; Lin, J.-T.; Lin, H.-L.; Liao, P.-L.; Wu, P.-J., et al. Phenolic compositions and antioxidant properties of leaves of eight persimmon varieties harvested in different periods. Food Chem. 289, 74-83 (2019). doi:10.1016\/j.foodchem.2019.03.048","DOI":"10.1016\/j.foodchem.2019.03.048"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Song, Y.-R.; Han, A.-R.; Lim, T.-G.; Kang, J.-H.; Hong, H.-D. Discrimination of structural and immunological features of polysaccharides from persimmon leaves at different maturity stages. Molecules 24, 356 (2019). doi:10.3390\/molecules24020356","DOI":"10.3390\/molecules24020356"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7) Jung, U.J.; Park, Y.B.; Kim, S.R.; Choi, M.-S. Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice. PLOS One 7, e49030 (2012). doi:10.1371\/journal.pone.0049030","DOI":"10.1371\/journal.pone.0049030"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) Bae, U.J.; Park, S.H.; Jung, S.Y.; Park, B.H.; Chae, S.W. Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes. Mol. Med. Rep. 12, 2547-2554 (2015). doi:10.3892\/mmr.2015.3766","DOI":"10.3892\/mmr.2015.3766"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) Lee, J.S.; Lee, M.K.; Ha, T.Y.; Bok, S.H.; Park, H.M., et al. Supplementation of whole persimmon leaf improves lipid profiles and suppresses body weight gain in rats fed high-fat diet. Food Chem. Toxicol. 44, 1875-1883 (2006). doi:10.1016\/j.fct.2006.06.014","DOI":"10.1016\/j.fct.2006.06.014"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Chen, L.; Ma, X.-B.; Liang, Y.-H.; Pei, S.-C.; Feng, Y.-P., et al. Effects of persimmon leaf total flavonoid on enzyme of lipoprotein metabolism and antioxidation in hyperlipidemia rats. Chin. J. Nat. Med. 9, 74-77 (2011). doi:10.1016\/S1875-5364(11)60024-1","DOI":"10.1016\/S1875-5364(11)60024-1"},{"key":"11","unstructured":"11) Lunagariya, N.A.; Patel, N.K.; Jagtap, S.C.; Bhutani, K.K. Inhibitors of pancreatic lipase: state of the art and clinical perspectives. EXCLI J. 13, 897-921 (2014)."},{"key":"12","doi-asserted-by":"publisher","unstructured":"12) Hadv\u00e1ry, P.; Lengsfeld, H.; Wolfer, H. Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. Biochem. J. 256, 357-361 (1988). doi:10.1042\/bj2560357","DOI":"10.1042\/bj2560357"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) Borgstr\u00f6m, B. Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin. Biochim. Biophys. Acta Lipids Lipid Metab. 962, 308-316 (1988). doi:10.1016\/0005-2760(88)90260-3","DOI":"10.1016\/0005-2760(88)90260-3"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14) Buchholz, T.; Melzig, M.F. Polyphenolic compounds as pancreatic lipase inhibitors. Planta Med. 81, 771-783 (2015). doi:10.1055\/s-0035-1546173","DOI":"10.1055\/s-0035-1546173"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15) Rocha, S.; Proen\u00e7a, C.; Ara\u00fajo, A.N.; Freitas, M.; Rufino, I., et al. Flavonoids as potential modulators of pancreatic lipase catalytic activity. Pharmaceutics 17, 163 (2025). doi:10.3390\/pharmaceutics17020163","DOI":"10.3390\/pharmaceutics17020163"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16) Li, M.-M.; Chen, Y.-T.; Ruan, J.-C.; Wang, W.-J.; Chen, J.-G., et al. Structure-activity relationship of dietary flavonoids on pancreatic lipase. Curr. Res. Food Sci. 6, 100424 (2023). doi:10.1016\/j.crfs.2022.100424","DOI":"10.1016\/j.crfs.2022.100424"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17) Li, S.; Pan, J.; Hu, X.; Zhang, Y.; Gong, D., et al. Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat. J. Funct. Foods 72, 104041 (2020). doi:10.1016\/j.jff.2020.104041","DOI":"10.1016\/j.jff.2020.104041"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18) Xing, Z.; Yu, H.; Yu, S.; Li, S.; Liu, Y., et al. To investigate the inhibitory effect of isoquercitrin on pancreatic lipase and its mechanism based on enzyme inhibition, multispectral analysis, molecular simulation and in vivo animal experiments. J. Mol. Struct. 1352, 144385 (2026). doi:10.1016\/j.molstruc.2025.144385","DOI":"10.1016\/j.molstruc.2025.144385"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Zou, Y.; Mei, C.; Liu, F.; Xing, D.; Pang, D., et al. The lipase inhibitory effect of mulberry leaf phenolic glycosides: the structure-activity relationship and mechanism of action. Food Chem. 458, 140228 (2024). doi:10.1016\/j.foodchem.2024.140228","DOI":"10.1016\/j.foodchem.2024.140228"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20) Singleton, V.L.; Orthofer, R.; Lamuela-Ravent\u00f3s, R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 299, 152-178 (1999). doi:10.1016\/S0076-6879(99)99017-1","DOI":"10.1016\/S0076-6879(99)99017-1"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21) Tan, Y.; Chang, S.K.C.; Zhang, Y. Comparison of \u03b1-amylase, \u03b1-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genres. Food Chem. 214, 259-268 (2017). doi:10.1016\/j.foodchem.2016.06.100","DOI":"10.1016\/j.foodchem.2016.06.100"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22) Bhuiya, M.A.I.; Yoshikiyo, K.; Moda, Y.; Fatima, P.K.S.K.; Murota, K. Functional evaluation of perilla leaf tea as a pancreatic lipase inhibitor: roles of rosmarinic acid and emulsion structure. Biosci. Biotechnol. Biochem. 90, 671-678 (2026). doi:10.1093\/bbb\/zbag021","DOI":"10.1093\/bbb\/zbag021"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Laborde, B.; Moine-Ledoux, V.; Richard, T.; Saucier, C.; Dubourdieu, D., et al. PVPP-polyphenol complexes: a molecular approach. J. Agric. Food Chem. 54, 4383-4389 (2006). doi:10.1021\/jf060427a","DOI":"10.1021\/jf060427a"},{"key":"24","unstructured":"24) Gopinathan, S.; Naveenraj, D. Antidiabetic activity of <i>Clerodendrum phlomidis<\/i> Linn. and <i>Gymnema sylvestre<\/i> Linn. in alloxan induced diabetic rats - a comparative preclinical study. World J. Pharm. Res. 3, 1640-1675 (2014)."},{"key":"25","doi-asserted-by":"publisher","unstructured":"25) Yoshikiyo, K.; Takahashi, M.; Narumiya, Y.; Honda, M.; Iwasaki, K., et al. Co-ingestion with \u03b3-cyclodextrin improves bioavailability of \u03b1-linolenic acid in <i>Perilla frutescens<\/i> seed oil. Food Hydrocoll. Health 3, 100116 (2023). doi:10.1016\/j.fhfh.2023.100116","DOI":"10.1016\/j.fhfh.2023.100116"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26) Birari, R.B.; Bhutani, K.K. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov. Today 12, 879-889 (2007). doi:10.1016\/j.drudis.2007.07.024","DOI":"10.1016\/j.drudis.2007.07.024"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) Luo, Z.; Murray, B.S.; Yusoff, A.; Morgan, M.R.A.; Povey, M.J.W., et al. Particle-stabilizing effects of flavonoids at the oil-water interface. J. Agric. Food Chem. 59, 2636-2645 (2011). doi:10.1021\/jf1041855","DOI":"10.1021\/jf1041855"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28) Oteiza, P.I.; Erlejman, A.G.; Verstraeten, S.V.; Keen, C.L.; Fraga, C.G. Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface? Clin. Dev. Immunol. 12, 19-25 (2005). doi:10.1080\/10446670410001722168","DOI":"10.1080\/10446670410001722168"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29) Tsuchiya, H. Structure-dependent membrane interaction of flavonoids associated with their bioactivity. Food Chem. 120, 1089-1096 (2010). doi:10.1016\/j.foodchem.2009.11.057","DOI":"10.1016\/j.foodchem.2009.11.057"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30) Shirai, M.; Moon, J.H.; Tsushida, T.; Terao, J. Inhibitory effect of a quercetin metabolite, quercetin 3-<i>O<\/i>-\u03b2-<sub>D<\/sub>-glucuronide, on lipid peroxidation in liposomal membranes. J. Agric. Food Chem. 49, 5602-5608 (2001). doi:10.1021\/jf010713g","DOI":"10.1021\/jf010713g"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31) Shahidi, F.; Athiyappan, K.D. Polyphenol-polysaccharide interactions: molecular mechanisms and potential applications in food systems - a comprehensive review. Food Prod. Process. Nutr. 7, 42 (2025). doi:10.1186\/s43014-025-00322-3","DOI":"10.1186\/s43014-025-00322-3"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32) Molet-Rodr\u00edguez, A.; M\u00e9ndez, D.A.; L\u00f3pez-Rubio, A.; Fabra, M.J.; Mart\u00ednez-Sanz, M., et al. Emulsification capacity of pectin extracts from persimmon waste: effect of structural characteristics and pectin-polyphenol interactions. Food Hydrocoll. 158, 110553 (2025). doi:10.1016\/j.foodhyd.2024.110553","DOI":"10.1016\/j.foodhyd.2024.110553"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33) Heck, A.M.; Yanovski, J.A.; Calis, K.A. Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy 20, 270-279 (2000). doi:10.1592\/phco.20.4.270.34882","DOI":"10.1592\/phco.20.4.270.34882"},{"key":"34","doi-asserted-by":"publisher","unstructured":"34) Patel, J.P.; Hardaswani, D.; Patel, J.; Saiyed, F.; Goswami, R.J., et al. Comparative effectiveness of semaglutide, liraglutide, orlistat, and phentermine for weight loss in obese individuals: a systematic review. Cureus 17, e80321 (2025). doi:10.7759\/cureus.80321","DOI":"10.7759\/cureus.80321"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35) Tsurunaga, Y.; Takabayashi, Y.; Nishi, M.; Suzuki, Y. Differences in the ascorbic acid, astragalin, and polyphenol contents, and the DPPH radical scavenging activity of 22 commercial persimmon leaf tea products. J. Home Econ. Japan 62, 437-444 (2011). doi:10.11428\/jhej.62.437","DOI":"10.11428\/jhej.62.437"}],"container-title":["Journal of Oleo Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/75\/8\/75_jos.ess26054\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:18:16Z","timestamp":1785557896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jos\/75\/8\/75_jos.ess26054\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5650\/jos.ess26054","relation":{},"ISSN":["1345-8957","1347-3352"],"issn-type":[{"value":"1345-8957","type":"print"},{"value":"1347-3352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"jos.ess26054"}}