{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:02:38Z","timestamp":1764194558311,"version":"3.37.3"},"reference-count":38,"publisher":"The Korean Society for Reproductive Medicine","issue":"2","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose.Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-Emax, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; \u03bb=8.27; relative standard error (\u03bb)=2.02%). The covariate analysis included women\u2019s age (p&lt;0.001), antral follicle count (p&lt;0.001), basal follicle-stimulating hormone level (p&lt;0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p&lt;0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group (n=139) showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use.Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.<\/jats:p>","DOI":"10.5653\/cerm.2020.03909","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T03:29:20Z","timestamp":1620790160000},"page":"163-173","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Novel nomogram-based integrated gonadotropin therapy individualization in in vitro fertilization\/intracytoplasmic sperm injection: A modeling approach"],"prefix":"10.5653","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-0815","authenticated-orcid":true,"given":"Abdel Hameed I 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