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We assessed liver injury-associated enzyme levels and circulating transforming growth factor beta (TGF-\u03b2) levels in an arginine vasopressin (AVP)-induced pregnant Sprague-Dawley rat model.Methods: Pregnant and non-pregnant Sprague-Dawley rats (n=24) received AVP (150 ng\/hr) subcutaneously via mini-osmotic pumps for 18 days. Blood pressure was measured, urine samples were collected, and all animals were euthanized via isoflurane. Blood was collected to measure circulating levels of TGF-\u03b21-3 isomers and liver injury enzymes in pregnant AVP (PAVP), pregnant saline (PS), non-pregnant AVP (NAVP), and non-pregnant saline (NS) rats. Results: The PAVP group showed significantly higher systolic and diastolic blood pressure than both saline-treated groups. The weight per pup was significantly lower in the AVP-treated group than in the saline group (p&lt;0.05). Circulating TGF-\u03b21-3 isomer levels were significantly higher in the PAVP rats than in the NS rats. However, similar TGF-\uf0621 and TGF-\uf0623 levels were noted in the PS and PAVP rats, while TGF-\uf0622 levels were significantly higher in the PAVP rats. Circulating liver-type arginase-1 and 5'-nucleotidase levels were higher in the PAVP rats than in the saline group. Conclusion: This is the first study to demonstrate higher levels of TGF-\u03b22, arginase, and 5'-nucleotidase activity in PAVP than in PS rats. AVP may cause vasoconstriction and increase peripheral resistance and blood pressure, thereby elevating TGF-\u03b2 and inducing the preeclampsia-associated inflammatory response. Future studies should explore the mechanisms through which AVP dysregulates liver injury enzymes and TGF-\u03b2 in pregnant rats.<\/jats:p>","DOI":"10.5653\/cerm.2020.04035","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T03:29:20Z","timestamp":1620790160000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transforming growth factor-beta and liver injury in an arginine vasopressin-induced pregnant rat 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