{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:48:34Z","timestamp":1785422914794,"version":"3.56.0"},"reference-count":29,"publisher":"The Korean Society for Reproductive Medicine","issue":"3","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>Objective: Platelet-rich plasma (PRP) therapy has received a considerable attention as an adjunct to fertility treatments, especially in women with very low ovarian reserve and premature ovarian insufficiency. Although recent studies have demonstrated that PRP led to improvements in folliculogenesis and biomarkers of ovarian reserve, the effect of intraovarian PRP administration on embryo genetics has not been studied.Methods: We report a pilot study of patients who had preimplantation genetic testing for aneuploidy (PGT-A) before and then within 3 months following PRP administration. Twelve infertile women with at least one prior failed in vitro fertilization (IVF) cycle underwent ovarian stimulation (cycle 1) with a gentle stimulation protocol and PGT-A performed at the blastocyst stage. Following cycle 1, autologous intraovarian PRP administration was performed. Within 3 months following PRP administration, the patients underwent cycle 2 and produced blastocysts for PGT-A. The percentage of euploid embryos between both cycles was compared.Results: The mean age of all participants was 40.08\u00b11.46 years, and their mean body mass index was 26.18\u00b11.18 kg\/m2. The number of good-quality embryos formed at the blastocyst stage was similar between cycle 1 and cycle 2 (3.08\u00b10.88 vs. 2.17\u00b10.49, respectively; p=0.11). Among all patients in cycle 1, 3 of 37 embryos were euploid (8.11%) while in cycle 2, 11 out of 28 embryos were euploid (39.28%, p=0.002). Three clinical pregnancies were noted among this patient group.Conclusion: This novel study is the first to present an improvement in the embryo euploidy rate following intraovarian PRP application in infertile women with prior failed IVF cycles. The growth factors present in PRP may exhibit a local paracrine effect that could improve meiotic aberrations in human oocytes and thus improve euploidy rates. Whether PRP improves live birth rates and lowers miscarriage rates remains to be determined in large trials.<\/jats:p>","DOI":"10.5653\/cerm.2021.05057","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T07:57:58Z","timestamp":1661932678000},"page":"210-214","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization"],"prefix":"10.5653","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-1428","authenticated-orcid":true,"given":"Zaher","family":"Merhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serin","family":"Seckin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mouanness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3624","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.036"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20190805"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1515\/med-2016-0048"},{"key":"ref4","first-page":"150","volume-title":"Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue 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infertility","author":"Colombo","year":"2017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719859539"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061809"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1445219"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00266-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01710-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2019.03405"},{"key":"ref20","first-page":"84","volume-title":"Normalized ploidy following 20 consecutive blastocysts with chromosomal error: healthy 46, XY pregnancy with IVF after intraovarian injection of autologous enriched platelet-derived growth factors","author":"Sills","year":"2019"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00655-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00579-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.03.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811x-12-26"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.04.007"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2003.10.008"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27713"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2018.1515272"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000489452"}],"container-title":["Clinical and Experimental Reproductive Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ecerm.org\/upload\/pdf\/cerm-2021-05057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ecerm.org\/journal\/view.php?doi=10.5653\/cerm.2021.05057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ecerm.org\/upload\/pdf\/cerm-2021-05057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T06:00:39Z","timestamp":1662012039000},"score":1,"resource":{"primary":{"URL":"http:\/\/ecerm.org\/journal\/view.php?doi=10.5653\/cerm.2021.05057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.5653\/cerm.2021.05057","relation":{},"ISSN":["2233-8233","2233-8241"],"issn-type":[{"value":"2233-8233","type":"print"},{"value":"2233-8241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2021-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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