{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:05:39Z","timestamp":1790373939937,"version":"4.1.0"},"reference-count":48,"publisher":"The Korean Society for Reproductive Medicine","issue":"4","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p>Objective: Oxidative stress is a key player in the development of idiopathic male infertility (IMI), and various antioxidants have been used for the treatment of IMI with inconsistent results. Coenzyme Q10 (CoQ10) is a cofactor and an antioxidant that may improve semen parameters and reduce oxidative stress in patients with idiopathic oligoasthenospermia (OA). Therefore, this study aimed to explore the effect of CoQ10 on semen parameters and antioxidant markers in patients with idiopathic OA.Methods: Fifty patients with idiopathic OA and 35 fertile controls were enrolled in this prospective controlled study. All participants underwent a comprehensive fertility assessment. All patients received CoQ10 (300 mg\/day) orally once daily for 3 months. Semen parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured in patients and controls at the start of the study and after 3 months.Results: Treatment with CoQ10 resulted in increased sperm progressive motility (p&lt;0.05), total motility (p&lt;0.01), seminal TAC (p&lt;0.01), SOD (p&lt;0.05), GPx (p&lt;0.001), and seminal CoQ10 (p&lt;0.001) levels and reduced ROS (p&lt;0.01) in patients as compared to baseline. Sperm concentration and motility were also significantly correlated with antioxidant measures and seminal CoQ10 levels (r=0.38\u20130.57).Conclusion: CoQ10 therapy (300 mg\/day for 3 months) improved sperm motility and seminal antioxidant markers in patients with idiopathic OA. Therefore, CoQ10 could be a promising treatment for patients with idiopathic infertility and may improve their fertility potential.<\/jats:p>","DOI":"10.5653\/cerm.2022.05463","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T02:18:55Z","timestamp":1667528335000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Coenzyme Q10 improves sperm motility and antioxidant status in infertile men with idiopathic oligoasthenospermia"],"prefix":"10.5653","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-5807","authenticated-orcid":true,"given":"Ahmed T","family":"Alahmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3624","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.03.085"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1309\/w8lj-k377-dhra-cp0b"},{"key":"ref4","first-page":"367","volume-title":"Male factor infertility: evaluation and management","author":"Brugh","year":"2004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"ref6","first-page":"25","volume-title":"Medical treatment of idiopathic oligozoospermia and male factor subfertility","author":"Adamopoulos","year":"2000"},{"key":"ref7","first-page":"761","volume-title":"Cinnoxicam and L-carnitine\/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia","author":"Cavallini","year":"2004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.69"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02251-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.14.12.729"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-126"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2020.04084"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200128"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)61641-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0219-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.015"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.03.008"},{"key":"ref18","first-page":"101","volume-title":"Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. 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