{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:58:53Z","timestamp":1780066733617,"version":"3.54.0"},"reference-count":29,"publisher":"The Korean Society for Reproductive Medicine","issue":"1","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p>Objective: The aim of this study was to investigate the effect of royal jelly (RJ), a powerful natural antioxidant, on cyclophosphamide-induced ovarian damage.Methods: Thirty-two Wistar albino rats were divided into four groups. Oral treatment was administered to all rats for 16 days after a single intraperitoneal injection. The control group received intraperitoneal and oral saline; the RJ group received intraperitoneal saline and 100 mg\/kg\/day oral RJ; the cyclophosphamide group received intraperitoneal 100 mg\/kg cyclophosphamide and oral saline; and the treatment group received intraperitoneal 100 mg\/kg cyclophosphamide and 100 mg\/kg\/day oral RJ. The groups were compared in terms of ovarian reserve tests and histopathological changes in the ovary and uterus.Results: All follicle counts were higher in the treatment group than in the cyclophosphamide group. The increase in the number of preantral follicles (p=0.001) and the decrease in the number of atretic follicles (p=0.004) were statistically significant. RJ treatment significantly improved follicular degeneration and cortical fibrosis in the ovary and epithelial and gland degeneration in the uterus due to cyclophosphamide toxicity.Conclusion: According to these results, RJ reduces cyclophosphamide-related ovarian and endometrial damage in rats. For this reason, it should be further investigated to determine its effects on reproductive function.<\/jats:p>","DOI":"10.5653\/cerm.2022.05596","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T06:25:57Z","timestamp":1677133557000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of royal jelly as a potential new drug to protect the ovarian reserve and uterus against cyclophosphamide in 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