{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:35:26Z","timestamp":1740162926758,"version":"3.37.3"},"reference-count":18,"publisher":"The Korean Society for Reproductive Medicine","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>Objective: The purpose of this study was to identify factors associated with twin pregnancy following day 3 double embryo transfer (DET).Methods: This retrospective cohort study incorporated data from 16,972 day 3 DET cycles. The participants were women aged between 18 and 45 years who underwent in vitro fertilization with intracytoplasmic sperm injection (IVF\/ICSI) at My Duc Assisted Reproduction Technique Unit (IVFMD), My Duc Hospital, located in Ho Chi Minh City, Vietnam.Results: Of the 16,972 day 3 DET cycles investigated, 8,812 (51.9%) resulted in pregnancy. Of these, 6,108 cycles led to clinical pregnancy, with 1,543 (25.3% of clinical pregnancies) being twin pregnancies. Factors associated with twin pregnancy included age under 35 years (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.32 to 1.71; &lt;i&gt;p&lt;\/i&gt;&lt;0.001) and cycles involving the transfer of at least one grade I embryo. Relative to the transfer of two grade III embryos, the risk of twin pregnancy was significantly elevated following the transfer of two grade I embryos (OR, 1.40; 95% CI, 1.16 to 1.69; &lt;i&gt;p&lt;\/i&gt;&lt;0.001) or a combination of one grade I and one grade II embryo (OR, 1.27; 95% CI, 1.05 to 1.55; &lt;i&gt;p&lt;\/i&gt;=0.001).Conclusion: By analyzing a large number of IVF\/ICSI cycles, we identified several predictors of twin pregnancy. These findings can assist medical professionals in tailoring treatment strategies for couples with infertility.<\/jats:p>","DOI":"10.5653\/cerm.2023.06156","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:55:40Z","timestamp":1703638540000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of twin pregnancy in in vitro fertilization with intracytoplasmic sperm injection cycles with day 3 double embryo transfer"],"prefix":"10.5653","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-1289","authenticated-orcid":true,"given":"Duy Le","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-0741","authenticated-orcid":true,"given":"Hieu Le-Trung","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1768-8393","authenticated-orcid":true,"given":"Vu Ngoc-Anh","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toan Duong","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Thanh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Thi-Thu","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-7358","authenticated-orcid":true,"given":"Tuong Manh","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-6912","authenticated-orcid":true,"given":"Lan Ngoc","family":"Vuong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3624","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.11.048"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-2082-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab029"},{"key":"ref5","first-page":"1586","volume-title":"ART in Europe, 2014: results generated from European registries by ESHRE: the European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)","author":"De Geyter","year":"2018"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.06.050"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq028"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003416.pub5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq352"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0039-5"},{"key":"ref12","first-page":"191","volume-title":"Factors that influence the occurrence of multiple pregnancies after intracytoplasmic injection cycles with two or three fresh embryo transfers","author":"Abdollahi","year":"2017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12687"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des258"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der037"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.13.1564-c"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.aog.0000153491.09525.dd"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.11.015"}],"container-title":["Clinical and Experimental Reproductive Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ecerm.org\/upload\/pdf\/cerm-2023-06156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ecerm.org\/journal\/view.php?doi=10.5653\/cerm.2023.06156","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ecerm.org\/upload\/pdf\/cerm-2023-06156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T01:31:37Z","timestamp":1709170297000},"score":1,"resource":{"primary":{"URL":"http:\/\/ecerm.org\/journal\/view.php?doi=10.5653\/cerm.2023.06156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"URL":"https:\/\/doi.org\/10.5653\/cerm.2023.06156","relation":{},"ISSN":["2233-8233","2233-8241"],"issn-type":[{"type":"print","value":"2233-8233"},{"type":"electronic","value":"2233-8241"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"2023-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-27","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}