{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:43:40Z","timestamp":1788536620134,"version":"build-2803163510"},"reference-count":27,"publisher":"The Korean Society for Reproductive Medicine","issue":"3","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>Objective: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients.Methods: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF).Results: PGT-A was associated with significant improvements in the implantation rate (IR) and the ongoing pregnancy rate\/live birth rate (OPR\/LBR) per embryo transfer cycle in the AMA (39.3% vs. 16.2% [p&lt;0.001] and 42.0% vs. 21.8% [p&lt;0.001], respectively), RIF (41.7% vs. 22.0% [p&lt;0.001] and 47.0% vs. 28.6% [p&lt;0.001], respectively), and RPL (45.6% vs. 19.5% [p&lt;0.001] and 49.1% vs. 24.2% [p&lt;0.001], respectively) groups, as well as the IR in the SMF group (43.3% vs. 26.5%, p=0.011). Additionally, PGT-A was associated with lower overall incidence rates of pregnancy loss in the AMA (16.7% vs. 34.3%, p=0.001) and RPL (16.7% vs. 50.0%, p&lt;0.001) groups. However, the OPR\/LBR per total cycle across all PGT-A groups did not significantly exceed that for the control groups.Conclusion: PGT-A demonstrated beneficial effects in high-risk patients. 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