{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:21:30Z","timestamp":1789150890974,"version":"build-2803163510"},"reference-count":32,"publisher":"The Korean Society for Reproductive Medicine","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>Objective: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients.Methods: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF).Results: PGT-A was associated with significant improvements in the implantation rate (IR) and the ongoing pregnancy rate\/live birth rate (OPR\/LBR) per embryo transfer cycle in the AMA (39.3% vs. 16.2% [&lt;i&gt;p&lt;\/i&gt;&lt;0.001] and 42.0% vs. 21.8% [&lt;i&gt;p&lt;\/i&gt;&lt;0.001], respectively), RIF (41.7% vs. 22.0% [&lt;i&gt;p&lt;\/i&gt;&lt;0.001] and 47.0% vs. 28.6% [&lt;i&gt;p&lt;\/i&gt;&lt;0.001], respectively), and RPL (45.6% vs. 19.5% [&lt;i&gt;p&lt;\/i&gt;&lt;0.001] and 49.1% vs. 24.2% [&lt;i&gt;p&lt;\/i&gt;&lt;0.001], respectively) groups, as well as the IR in the SMF group (43.3% vs. 26.5%, &lt;i&gt;p&lt;\/i&gt;=0.011). Additionally, PGT-A was associated with lower overall incidence rates of early pregnancy loss in the AMA (16.7% vs. 34.3%, &lt;i&gt;p&lt;\/i&gt;=0.001) and RPL (16.7% vs. 50.0%, &lt;i&gt;p&lt;\/i&gt;&lt;0.001) groups. However, the OPR\/LBR per total cycle across all PGT-A groups did not significantly exceed that for the non-PGT-A groups.Conclusion: PGT-A demonstrated beneficial effects in high-risk patients. However, our findings indicate that these benefits are more pronounced in carefully selected candidates than in the entire high-risk patient population.<\/jats:p>","DOI":"10.5653\/cerm.2023.06394","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T04:09:40Z","timestamp":1703650180000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical outcomes of preimplantation genetic testing for aneuploidy in high-risk patients: a retrospective cohort study"],"prefix":"10.5653","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-5076","authenticated-orcid":true,"given":"Jun Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang 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